DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31365 and MYNN

DIOPT Version :9

Sequence 1:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001172047.1	Gene:	MYNN / 55892	HGNCID:	14955	Length:	610	Species:	Homo sapiens

Alignment Length:	641	Identity:	148/641 - (23%)
Similarity:	227/641 - (35%)	Gaps:	185/641 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 CRYQLEKSFLFRQR-----CQW----AEKKLRKHIRLLG-----LGKRSRVFSKDPDDYDEDELE 113
            |.:.||:  |.:||     |..    .|.:.:.|..:|.     .|...|..|::....|:.:::
Human     7 CEHLLER--LNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIYRSTSENNVFLDQSQVK 69

  Fly   114 ---FEDSIAFIEVQDKVRKLEDEKWREDFKE-EQAAEMHKRLVKSRLELRAKLTTELRKELAEEV 174
               |:..:.||    ....|..:.|  :.|| .|||:.   |....:..:.|:..|....:|...
Human    70 ADGFQKLLEFI----YTGTLNLDSW--NVKEIHQAADY---LKVEEVVTKCKIKMEDFAFIANPS 125

  Fly   175 RSEVRK-----ELAEEVRSQVRDDLRN----EVSEDIRKEQLAMLLGELEVYLTEKKAGRWESLD 230
            .:|:..     ||.::.......|..|    |||.|:.:              ...|.|   :|.
Human   126 STEISSITGNIELNQQTCLLTLRDYNNREKSEVSTDLIQ--------------ANPKQG---ALA 173

  Fly   231 GSEPETKPQVKEDASPSRSKTKALPKRRPSLVDANLKATEARKDAKEEEFILGCNTDPA------ 289
            ....:||.:.|...||...:.|.:......|.:|::            |..|..|..|.
Human   174 KKSSQTKKKKKAFNSPKTGQNKTVQYPSDILENASV------------ELFLDANKLPTPVVEQV 226

  Fly   290 ----NNSDVNIDGLELDEEVPAESGEDFREINMVGSDVVHTDNGEIYIINSASSEDQNQDSTPEF 350
                :||::.:..: ::...||:             |:|||     ..:.....:.|...:..|.
Human   227 AQINDNSELELTSV-VENTFPAQ-------------DIVHT-----VTVKRKRGKSQPNCALKEH 272

  Fly   351 DQDNGITSYNIKEDGEIQFSGEKPEEIEDVVVFNLGEEISQEQ-----------QVFSFHENVII 404
            ...| |.|.            :.|.|.|     |.|||:.|..           :|||
Human   273 SMSN-IASV------------KSPYEAE-----NSGEELDQRYSKAKPMCNTCGKVFS------- 312

  Fly   405 VEKEQNDRDEQTPLKRKRSSELVFKQESSCPQPKTGRITDTVKSFQCHLCPVAFPTQKLLTRHHN 469
                     |.:.|:|..                  ||...||.:.||||..||.....|..|..
Human   313 ---------EASSLRRHM------------------RIHKGVKPYVCHLCGKAFTQCNQLKTHVR 350

  Fly   470 THI-----------KG------------LKSGKGGTLKCPSCALQLSCASSLKRHMIIHTGLKPF 511
            ||.           ||            :..|:....||..|.||.:.:|:||.|...|:|.||:
Human   351 THTGEKPYKCELCDKGFAQKCQLVFHSRMHHGEEKPYKCDVCNLQFATSSNLKIHARKHSGEKPY 415

  Fly   512 KCSECELSFSQREVLKRHMDTHTGVKRHQCPQCSSCFAQKSNLQQHIGRVHMGNSRTHKCHLCHR 576
            .|..|...|:|...|..|:..|||.|.:.|..|...||..|:|..| .|.|.| .:.:.|.:|.:
Human   416 VCDRCGQRFAQASTLTYHVRRHTGEKPYVCDTCGKAFAVSSSLITH-SRKHTG-EKPYICGICGK 478

  Fly   577 SFNHVSGLSRHLVTHAGVM-FSCKQCGRQFNDRSAVQRHVTTMHKVKNKLTDYISE 631
            ||.....|::|..:|.|.. |.|:.||..:.|...:::|.|.:|...:|..|..:|
Human   479 SFISSGELNKHFRSHTGERPFICELCGNSYTDIKNLKKHKTKVHSGADKTLDSSAE 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871	8/31 (26%)
		vATP-synt_E	109..>244	CDD:304907	29/147 (20%)
		RRF	<161..222	CDD:294170	12/69 (17%)
		zf-C2H2_8	454..530	CDD:292531	28/98 (29%)
		C2H2 Zn finger	485..505	CDD:275368	8/19 (42%)
		zf-H2C2_2	497..522	CDD:290200	10/24 (42%)
		C2H2 Zn finger	513..533	CDD:275368	6/19 (32%)
		zf-H2C2_2	526..550	CDD:290200	9/23 (39%)
		C2H2 Zn finger	541..562	CDD:275368	8/20 (40%)
		C2H2 Zn finger	571..591	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..617	CDD:275368	5/18 (28%)
MYNN	NP_001172047.1	BTB	14..115	CDD:306997	23/109 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..197		8/30 (27%)
		Nuclear localization signal. /evidence=ECO:0000255	174..190		4/15 (27%)
		Nuclear localization signal. /evidence=ECO:0000255	257..262		0/4 (0%)
		C2H2 Zn finger	304..324	CDD:275368	7/53 (13%)
		zf-C2H2	304..324	CDD:306579	7/53 (13%)
		zf-H2C2_2	316..341	CDD:316026	12/42 (29%)
		C2H2 Zn finger	332..352	CDD:275368	8/19 (42%)
		zf-H2C2_2	345..369	CDD:316026	6/23 (26%)
		SFP1	<354..438	CDD:227516	22/83 (27%)
		C2H2 Zn finger	360..380	CDD:275368	2/19 (11%)
		C2H2 Zn finger	389..409	CDD:275368	8/19 (42%)
		C2H2 Zn finger	417..437	CDD:275368	6/19 (32%)
		zf-H2C2_2	430..453	CDD:316026	8/22 (36%)
		SFP1	<439..522	CDD:227516	27/84 (32%)
		C2H2 Zn finger	445..465	CDD:275368	8/20 (40%)
		C2H2 Zn finger	473..493	CDD:275368	6/19 (32%)
		C2H2 Zn finger	501..522	CDD:275368	6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..556		4/14 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910