DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31365 and ZNF83

DIOPT Version :9

Sequence 1:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001099019.1	Gene:	ZNF83 / 55769	HGNCID:	13158	Length:	516	Species:	Homo sapiens

Alignment Length:	454	Identity:	110/454 - (24%)
Similarity:	186/454 - (40%)	Gaps:	97/454 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 EDIRKEQLAMLLG--------ELEVYLTEKKAGRWESLDGSEPETKPQVKEDASPSRSKTKALPK 256
            :|.:|:.:...||        ||:::..|.|..:::.:             :.|.:.|...:.|:
Human     6 DDAQKQPVKNQLGLNPQSHLPELQLFQAEGKIYKYDHM-------------EKSVNSSSLVSPPQ 57

  Fly   257 RRPSLVDANLKATEARKDAKEEEFILGCNTDPANNSDVNIDGLELDEEVP---------AESGED 312
            |..|.|..::..|            ..||.         :|.|...:|..         :|.|:.
Human    58 RISSTVKTHISHT------------YECNF---------VDSLFTQKEKANIGTEHYKCSERGKA 101

  Fly   313 FRE-INMVGSDVVHTDN--------GEIY--IINSASSEDQNQDSTPEFDQDNGITSYNIKEDGE 366
            |.: ::.....::||..        |:|:  ..|.||.:..:....|....:.|...:|:....:
Human   102 FHQGLHFTIHQIIHTKETQFKCDICGKIFNKKSNLASHQRIHTGEKPYKCNECGKVFHNMSHLAQ 166

  Fly   367 IQ--FSGEKPEEIEDV-VVFNLGEEISQEQQVFSFHENVIIVEKEQNDRDEQTPLKRKRSSELVF 428
            .:  .:||||.:..:. .|||....::|.|::.:                .:.|.|.....: ||
Human   167 HRRIHTGEKPYKCNECGKVFNQISHLAQHQRIHT----------------GEKPYKCNECGK-VF 214

  Fly   429 KQESSCPQPKTGRITDTVKSFQCHLCPVAFPTQKLLTRHHNTHIKGLKSGKGGTLKCPSCALQLS 493
            .|.|...|.:|  |....|.::|:.|...|.....|.:|...| .|.|     ..:|..|.....
Human   215 HQISHLAQHRT--IHTGEKPYECNKCGKVFSRNSYLVQHLIIH-TGEK-----PYRCNVCGKVFH 271

  Fly   494 CASSLKRHMIIHTGLKPFKCSECELSFSQREVLKRHMDTHTGVKRHQCPQCSSCFAQKSNLQQHI 558
            ..|.|.:|..||||.||:||:||...||.:..|..|...|||.|.::|.:|...|:.||:|..|
Human   272 HISHLAQHQRIHTGEKPYKCNECGKVFSHKSSLVNHWRIHTGEKPYKCNECGKVFSHKSSLVNH- 335

  Fly   559 GRVHMGNSRTHKCHLCHRSFNHVSGLSRHLVTHAGVM-FSCKQCGRQFNDRSAVQRHVTTMHKV 621
            .|:|.| .:.:||:.|.:.|:..|.|::||:.|||.. :.|.:|.:.|:..|    |:...|::
Human   336 WRIHTG-EKPYKCNECGKVFSRNSYLAQHLIIHAGEKPYKCDECDKAFSQNS----HLVQHHRI 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871
		vATP-synt_E	109..>244	CDD:304907	8/51 (16%)
		RRF	<161..222	CDD:294170	7/29 (24%)
		zf-C2H2_8	454..530	CDD:292531	25/75 (33%)
		C2H2 Zn finger	485..505	CDD:275368	5/19 (26%)
		zf-H2C2_2	497..522	CDD:290200	13/24 (54%)
		C2H2 Zn finger	513..533	CDD:275368	7/19 (37%)
		zf-H2C2_2	526..550	CDD:290200	9/23 (39%)
		C2H2 Zn finger	541..562	CDD:275368	8/20 (40%)
		C2H2 Zn finger	571..591	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..617	CDD:275368	5/18 (28%)
ZNF83	NP_001099019.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		4/13 (31%)
		C2H2 Zn finger	95..115	CDD:275368	3/19 (16%)
		COG5048	117..507	CDD:227381	85/309 (28%)
		C2H2 Zn finger	123..143	CDD:275368	5/19 (26%)
		C2H2 Zn finger	151..171	CDD:275368	2/19 (11%)
		C2H2 Zn finger	179..199	CDD:275368	5/19 (26%)
		C2H2 Zn finger	207..227	CDD:275368	6/22 (27%)
		C2H2 Zn finger	235..255	CDD:275368	5/19 (26%)
		C2H2 Zn finger	263..283	CDD:275368	5/19 (26%)
		C2H2 Zn finger	291..311	CDD:275368	7/19 (37%)
		C2H2 Zn finger	319..339	CDD:275368	8/20 (40%)
		C2H2 Zn finger	347..367	CDD:275368	7/19 (37%)
		C2H2 Zn finger	375..395	CDD:275368	6/24 (25%)
		C2H2 Zn finger	403..423	CDD:275368
		C2H2 Zn finger	431..451	CDD:275368
		C2H2 Zn finger	459..479	CDD:275368
		C2H2 Zn finger	487..507	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4907
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950