DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31365 and CG4707

DIOPT Version :9

Sequence 1:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_611944.1	Gene:	CG4707 / 37935	FlyBaseID:	FBgn0035036	Length:	673	Species:	Drosophila melanogaster

Alignment Length:	718	Identity:	151/718 - (21%)
Similarity:	253/718 - (35%)	Gaps:	194/718 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 TLCRLCLKEHQDAYAIFDEDDTQLSIPVRLMACVALDAKATDTLPKRICQEC--------RYQLE 68
            |:|.|||......|.:..|:..:|:|...:....|.....|......:|:||        .:...
  Fly     2 TVCVLCLDSSNAGYGLQSEEGVRLNIRATIHKHFAFSEVLTAGGDAEVCRECWNCVSSFEEFHQR 66

  Fly    69 KSFLFRQR-----------CQWAEKKLRKHIRLLGLGKRSRVFSKDPDDYDEDELEFEDSIAFIE 122
            .|.|.|||           |...|:.:...:..:.|...:..|      :...|::.|  :..:|
  Fly    67 VSCLHRQRSSDSKSEPIEFCGQTEEAIINPLYSVELDALAEAF------FAPSEVKVE--VNELE 123

  Fly   123 VQDKVRKLEDEKWREDFKEEQAAEMHKRLVKSRLELRAKLTTELRKELAEE--VRSEVRKELAEE 185
            ...||..|||           ..:...|....||.:..:.:...::.:..|  |.|:....||:.
  Fly   124 PLPKVELLED-----------PVKTEIRTAPKRLGVPNEGSPHSKRRIKNELPVDSDSDAPLADF 177

  Fly   186 VRSQVRDDLRNEV-----SEDIRKEQLAMLLGELEVYLTEKKAGRWESLDGSEPETKPQVKEDAS 245
            :.|   |..|:.|     ||..:..||            .:.|.|     |..|:.||    :::
  Fly   178 LNS---DSKRSSVGPAKNSEANKGRQL------------RRSARR-----GRPPKAKP----ESA 218

  Fly   246 PSRSKTKALPKRRPSLVDANLKATEARKDAKEEEF-----ILGCNTDPANNSDVNIDGLELDEEV 305
            ||       ||:.....|..    |..:|..:.||     :||  ||.:::|.....|.:.|..:
  Fly   219 PS-------PKKELDSEDGE----ENARDNNDMEFVAPEAVLG--TDDSSSSSSESSGEDSDHSL 270

  Fly   306 P-AESGEDFREI--NMVGSDVVHTDNGEIYIINSASSEDQ------NQDSTPEFDQ--------- 352
            | .|..|.:.||  .:|.....:....:..:.....|.::      .||   |:|:
  Fly   271 PDIEPEERYAEIPKRVVVKPKKYRKREKPLVPPVRLSREEIERRKLQQD---EYDEIILQFFKKF 332

  Fly   353 ----------------DNGITSYNIKEDGEIQFSGEKPEEIEDVVVFNLGEEISQEQQVFSFHEN 401
                            .:...|:|| |.|.|:..|.|         |:|.:.:::...|   |:|
  Fly   333 PCSLCNLLVQNFADMRRHQRVSHNI-ESGYIECCGRK---------FHLRKALAEHVLV---HKN 384

  Fly   402 VIIVEKEQNDRDEQTPLKRKRSSELVFKQESSCP----QPKTGRITDTVKSFQCHLCPVAFPTQK 462
            .......|..|..|.    .|:.| |.:|..:.|    :||..||      :||..||.:|.|:.
  Fly   385 PDHFMCSQCGRVFQD----SRALE-VHEQTHTNPEVKAEPKEKRI------YQCEKCPKSFTTKA 438

  Fly   463 LLTRHH-NTHIKGLKSGKGGTLKCPSCALQLSCASSLKRHM-IIHTGLKPFKCSECELSFSQREV 525
            .:..|. :.|:...:.    ...||.|..::.....||.|: .:|.......|.:|..:...:..
  Fly   439 AMEYHDVSKHVPKSEF----KYSCPECNKKIPTERKLKEHLRYMHDPEAAIICDKCGKTLRSQTN 499

  Fly   526 LKRHMDTHTGVKRH------QCPQCSSCFAQKSNLQQHIGRVHMGNSRTHKCHLCHRSFNHVSGL 584
            ||:|.:.....|..      ||..|.:.....|.|:||:..||......|:||:|:::..:...|
  Fly   500 LKKHHELEHSEKPRPKPDPVQCEICGTWLRHLSGLKQHMKTVHEPPGDEHRCHICNKTSTNSRAL 564

  Fly   585 SRHLV-----------------------------THAG-VMFSCKQCGRQFNDRSAVQRHVTTMH 619
            .||:.                             ||.| |:::|..|...|...:.:.:|...:|
  Fly   565 KRHIYHNHLCERKFKCGMCEKAFKRPQDLREHTSTHTGEVLYTCPNCPMTFFSNANMYKHRQRLH 629

  Fly   620 KVK 622
            :.:
  Fly   630 RAE 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871	20/91 (22%)
		vATP-synt_E	109..>244	CDD:304907	30/141 (21%)
		RRF	<161..222	CDD:294170	13/67 (19%)
		zf-C2H2_8	454..530	CDD:292531	17/77 (22%)
		C2H2 Zn finger	485..505	CDD:275368	6/20 (30%)
		zf-H2C2_2	497..522	CDD:290200	6/25 (24%)
		C2H2 Zn finger	513..533	CDD:275368	5/19 (26%)
		zf-H2C2_2	526..550	CDD:290200	7/29 (24%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	571..591	CDD:275368	6/48 (13%)
		C2H2 Zn finger	598..617	CDD:275368	4/18 (22%)
CG4707	NP_611944.1	zf-AD	3..73	CDD:285071	15/69 (22%)
		C2H2 Zn finger	334..355	CDD:275368	0/20 (0%)
		LIM	<361..407	CDD:295319	14/62 (23%)
		C2H2 Zn finger	365..382	CDD:275368	5/28 (18%)
		C2H2 Zn finger	390..410	CDD:275368	7/24 (29%)
		C2H2 Zn finger	427..443	CDD:275368	5/15 (33%)
		C2H2 Zn finger	458..476	CDD:275368	6/17 (35%)
		C2H2 Zn finger	487..507	CDD:275368	5/19 (26%)
		C2H2 Zn finger	521..540	CDD:275368	6/18 (33%)
		C2H2 Zn finger	551..572	CDD:275368	6/20 (30%)
		C2H2 Zn finger	580..600	CDD:275368	0/19 (0%)
		C2H2 Zn finger	608..629	CDD:275368	4/20 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4907
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.950