DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31365 and CG10321

DIOPT Version :9

Sequence 1:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001261124.1	Gene:	CG10321 / 37464	FlyBaseID:	FBgn0034643	Length:	855	Species:	Drosophila melanogaster

Alignment Length:	828	Identity:	157/828 - (18%)
Similarity:	308/828 - (37%)	Gaps:	265/828 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DLATLCRLCLKEHQDAYAIFDEDDTQLSIPVRLMACVALDAKATDTLPKRICQECRYQLEKSFLF 73
            :|..:||||:.|.::...:|.|     .:|..||.|.::..:.|:..|.:||.:|.:.:.::..|
  Fly     8 ELDKICRLCISERKEMRPLFSE-----KVPEMLMDCTSVRVEPTEGWPDKICVQCVHAVSRNHAF 67

  Fly    74 RQRCQWAEKKLRKHIRLLGLGKRSRVFSKDPDDYDEDELEFEDSIAFIEVQ---------DKVRK 129
            :...:.::|:||::||.|.:..           ..|::.:.|.:.|..::|         .|.:|
  Fly    68 KTLVERSDKELREYIRGLTVAL-----------VMEEQQQQEAANAKQQLQLERKQQRQLQKQQK 121

  Fly   130 LEDEKWREDFKEEQAAEMHKRLVKSRLE--LRAKLTTELRKEL------------AEEVRSEVRK 180
            :.:|:.::...::|   .|:...|.:|:  ||.....:.::.|            |.:.:.::.:
  Fly   122 ILEEQLQQQIVQQQ---QHQPPAKPKLKPLLRKGSRQQKQRHLEAAPAPQSVPQPAPQPQMQLMQ 183

  Fly   181 ELAEE---VRSQVRD---------------------DLRNEV---------SEDIRKEQLAMLLG 212
            |.|.:   ::.|::.                     .:..::         :..|...|||.::.
  Fly   184 EHAPQQPTMQQQIQQIHMPTLQPAPAQLLSAAGATTTMPQQILLPNGQLITTAQIVAPQLAQIIS 248

  Fly   213 ELEVYLTEKKAGRWESLDGSEPETKPQVKEDAS---------PSRSKT----KALPKRR------ 258
            ......|..:|      ..::.:..||:.:..:         |:.::|    :.:|:|.
  Fly   249 TAPQSTTNGQA------TAAQSQFLPQLLQTPNGQTLQIVQQPNGTQTLQLVQLVPQRSLAPTGV 307

  Fly   259 -----------------PSLVDANLKATEARKDAKEEEFILGCNTDPANNSDVNIDGLELDEEVP 306
                             .||.||:::..|...:.::|| :........:.:|.:.:.:.||::..
  Fly   308 TTVTTTTNATDMGQHVGASLGDADVQLLEDGCEVEDEE-LEDVYEQLDSKADHSFETIVLDDDQQ 371

  Fly   307 AESGEDFREIN--MVGSDVVHTDNGEIYIINSASS-------EDQNQDSTPEFDQDNGITSYNIK 362
            .:..:|..|.:  |:..|:..:::.:....:....       ||:.:...||.|||..|......
  Fly   372 QDFLKDHHEHHQVMINEDLTQSESQDHEYFDDLDQQQAMDEIEDEEEQMKPEEDQDTFIIEEIQL 436

  Fly   363 EDGEI-------------QFSGEKPE-----EIEDVVVFNL-----GEEISQEQQVFSFHENVII 404
            ||.|:             ::.||:.:     :::|.:.:::     ||......|.|
  Fly   437 EDDEMLDDPDGEEIDQDCEYIGEEQDPHLSGDVDDDLEYSIMEPPDGETSVDIDQAF-------- 493

  Fly   405 VEKEQNDRDEQTPLKRKRSSE---LVFKQESSCPQPKTGRITDTVKSFQCHLCPVAFPTQKLLTR 466
            ::.||:...:.....:..|.|   :.|.|.::..:...|. |.||.|        |.||.|...|
  Fly   494 MDSEQSHHQQHQEEMQSISLENAVVEFSQATTTTEALVGP-TMTVSS--------ASPTPKRAKR 549

  Fly   467 HHNTHIKGLKSGKGGTLK-C---PSCA-----LQLSCASSLKRHMI------------------- 503
            .::      :...|.||: |   |..|     .:|:.|:|  |.::
  Fly   550 SNH------QIPAGVTLEPCDHQPPAAGSTTSSKLAAANS--RQLVQTASVIAAAGADDNYEIDA 606

  Fly   504 --------IHT---GLKPFKCSECELSFSQREVLKRHMDTHTGVKRHQC---PQCSSC---FAQK 551
                    .||   |...:.|..|...|.|.:.|:.||.:||...|..|   |||..|   |...
  Fly   607 NLVTEFIRQHTSPLGSGRYICHLCSTEFRQFKGLQNHMHSHTNWIRANCKKQPQCQICLKSFKGP 671

  Fly   552 SNLQQHIGRVHMGNSRTHKCHLCHRSFNHVSGLSRHLVTH------AGV---------------- 594
            ..|:.|: :.|...|.|..|.:|:|:|...:.|.||..||      .||
  Fly   672 GMLRMHM-KTHDAESSTPMCTICNRTFKSKAILYRHRQTHQQRAYCCGVANCRKNFSSAVNLKWH 735

  Fly   595 -----------MFSCKQCGRQFNDRSAVQRHVTTMHKVKNKLTDYISE 631
                       :|.|.:||..:::..::|.||.:        ||:.:|
  Fly   736 VERKHPEVVDPLFKCGECGSLYDNVDSLQLHVES--------TDHSAE 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871	19/72 (26%)
		vATP-synt_E	109..>244	CDD:304907	26/190 (14%)
		RRF	<161..222	CDD:294170	10/105 (10%)
		zf-C2H2_8	454..530	CDD:292531	23/114 (20%)
		C2H2 Zn finger	485..505	CDD:275368	7/54 (13%)
		zf-H2C2_2	497..522	CDD:290200	8/54 (15%)
		C2H2 Zn finger	513..533	CDD:275368	7/19 (37%)
		zf-H2C2_2	526..550	CDD:290200	12/29 (41%)
		C2H2 Zn finger	541..562	CDD:275368	8/26 (31%)
		C2H2 Zn finger	571..591	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..617	CDD:275368	6/18 (33%)
CG10321	NP_001261124.1	zf-AD	12..80	CDD:214871	19/72 (26%)
		ASF1_hist_chap	<405..516	CDD:304562	22/118 (19%)
		C2H2 Zn finger	627..647	CDD:275368	7/19 (37%)
		C2H2 Zn finger	661..681	CDD:275368	5/20 (25%)
		C2H2 Zn finger	690..710	CDD:275368	7/19 (37%)
		C2H2 Zn finger	717..740	CDD:275368	2/22 (9%)
		C2H2 Zn finger	750..767	CDD:275368	4/16 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910