DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31365 and ZNF233

DIOPT Version :9

Sequence 1:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_024307256.1	Gene:	ZNF233 / 353355	HGNCID:	30946	Length:	727	Species:	Homo sapiens

Alignment Length:	710	Identity:	149/710 - (20%)
Similarity:	244/710 - (34%)	Gaps:	214/710 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 LPKRICQECRYQLEKSFLFRQRCQWAEKKL---RKHIRLLGLGKRSRVFSKDPDDYDEDELE--- 113
            ||::       :.||...|::...:.:..:   |:.:.||.|.:|..        |.:..||
Human    50 LPQK-------EQEKMTKFQEMVTFKDVAVVFTREELGLLDLAQRKL--------YQDVMLENFR 99

  Fly   114 ---------FE-DSIAFIEVQDKVRKLEDEKWREDFKEEQAAEMHKR------LVKSRL------ 156
                     |: |.|..:..:||:|.:|.|      .:......||.      |.:.||
Human   100 NLLSVGYQPFKLDVILQLGKEDKLRMMETE------IQGDGCSGHKNQNEIDTLQEVRLRFLSYE 158

  Fly   157 ---------ELRAKLTTE---------LRKELAEEVRSEVRKELAEEVRSQVRDD------LRNE 197
                     :..:|||:.         .|.:|.::..|..:....|.  |||.:|      |:.|
Human   159 DLICWQIWEQFTSKLTSNQDLIINLQGKRSKLLKQGDSPCQVWTGES--SQVSEDENYVIKLQGE 221

  Fly   198 VSEDIRKEQLAMLLG---ELEVYLTEKK--AGRWESLDGSEPETKPQ--VKE------DASPSRS 249
            .|..|:.::|.:...   ..::||.|.:  ..|.:.:|......|..  |::      |......
Human   222 SSNSIKNQELPLRTTWDFWRKMYLREPQNYQSRCQQIDVKNKLCKCDHCVRQRIAHQHDDHGVHK 286

  Fly   250 KTKALPKR-------RPSLVDANLKATEARKDAKEEEFILGCNTD------PANNSDVNID---G 298
            :.||....       :.|...:.:::.|...|...:...:|.|.:      ..:...||::   |
Human   287 REKAFSHNNCGKDCVKESSQHSIIQSGEQTSDENGKGLSVGSNLELHQQLHLRDKPHVNVEYGKG 351

  Fly   299 LELDEEVP--------------AESGEDFREINMVGSDV---VHTDNGEIYIINSASSEDQNQDS 346
            :.....:|              .:|||.|.:    ||.:   .....||........:...||:|
Human   352 IGYSSGLPRHQCFHIGEKCYRNGDSGEGFSQ----GSHLQPHQRVSTGENLYRCQVYARSSNQNS 412

  Fly   347 TPEFDQDNGITSYNIKEDGE----------------------IQFSGEKPEEIEDVVVFNLG-EE 388
            .        :.|:.:...||                      :..:||:..:.:   |::.| .:
Human   413 C--------LPSHELTHPGEKLCTCGRCGKGFHHSLDFDIHCVDSAGERACKCD---VYDKGFSQ 466

  Fly   389 ISQEQQVFSFHENVIIVEKEQNDRDEQTPLKRKRSSELVFKQESSCPQPKTGRITDTVKSFQCHL 453
            .||.|.....|......:.|.:||              :|.:.|...|    |:....|.::|.:
Human   467 TSQLQAHQRGHSRDKTYKWEVSDR--------------IFNRNSGLHQ----RVHTGEKPYKCEV 513

  Fly   454 CPVAFPTQKLLTRHHNTHIKGLKSGKGGTLKCPSCALQLSCASSLKRHMIIHTGLKPFKCSECEL 518
            |...|.....|..|...| .|.|     ..||..|....|..|.|:.|..:|||.||:||..|..
Human   514 CDKGFSKASNLQAHQRIH-TGEK-----PYKCDVCDKNFSRNSHLQAHQRVHTGEKPYKCDTCGK 572

  Fly   519 SFSQREVLKRHMDTHTGVKRHQCPQCSSCFAQKSNLQQHIGRVHMGNSRTHKCHLCHRSFNHVSG 583
            .|||...|:.|...|.|.|.::|..|...|:|.|:||.| .:||.|.: .:||.:|.:.|:..|.
Human   573 DFSQISHLQAHQRVHKGEKPYKCETCGKGFSQSSHLQDH-QQVHTGEN-PYKCDVCGKGFSWSSH 635

  Fly   584 LSRHLVTHAGVM-----------------------------FSCKQCGRQFNDRSAVQRH 614
            |..|...|.|..                             :.|..||:.|:..|.:|.|
Human   636 LQAHQRVHTGEKPYKCEECRKGFIWNSYLHVHQRIHTGEKPYKCGMCGKSFSQTSHLQAH 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871	5/33 (15%)
		vATP-synt_E	109..>244	CDD:304907	38/196 (19%)
		RRF	<161..222	CDD:294170	19/78 (24%)
		zf-C2H2_8	454..530	CDD:292531	26/75 (35%)
		C2H2 Zn finger	485..505	CDD:275368	6/19 (32%)
		zf-H2C2_2	497..522	CDD:290200	11/24 (46%)
		C2H2 Zn finger	513..533	CDD:275368	7/19 (37%)
		zf-H2C2_2	526..550	CDD:290200	8/23 (35%)
		C2H2 Zn finger	541..562	CDD:275368	8/20 (40%)
		C2H2 Zn finger	571..591	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..617	CDD:275368	7/17 (41%)
ZNF233	XP_024307256.1	KRAB	65..123	CDD:214630	12/65 (18%)
		C2H2 Zn finger	321..337	CDD:275368	2/15 (13%)
		C2H2 Zn finger	345..365	CDD:275368	3/19 (16%)
		C2H2 Zn finger	377..393	CDD:275368	5/19 (26%)
		C2H2 Zn finger	401..421	CDD:275368	4/27 (15%)
		C2H2 Zn finger	429..449	CDD:275368	0/19 (0%)
		COG5048	<507..656	CDD:227381	52/156 (33%)
		C2H2 Zn finger	511..531	CDD:275368	5/19 (26%)
		C2H2 Zn finger	539..559	CDD:275368	6/19 (32%)
		C2H2 Zn finger	567..587	CDD:275368	7/19 (37%)
		C2H2 Zn finger	595..615	CDD:275368	8/20 (40%)
		C2H2 Zn finger	623..643	CDD:275368	6/19 (32%)
		C2H2 Zn finger	651..671	CDD:275368	0/19 (0%)
		zf-C2H2	677..699	CDD:306579	7/19 (37%)
		C2H2 Zn finger	679..699	CDD:275368	7/17 (41%)
		zf-H2C2_2	691..714	CDD:316026	2/5 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100