DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31365 and ZNF260

DIOPT Version :9

Sequence 1:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001012774.1	Gene:	ZNF260 / 339324	HGNCID:	13499	Length:	412	Species:	Homo sapiens

Alignment Length:	274	Identity:	79/274 - (28%)
Similarity:	123/274 - (44%)	Gaps:	39/274 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   355 GITSYNIKEDG------------EIQFSGEKPEEIEDVVVFNLGEEISQEQQVFSFHENVIIVEK 407
            |...|..||.|            |...:||||.|..     ..|...||:|.:.          |
Human   132 GTKPYACKECGKAFNGKAYLTEHEKIHTGEKPFECN-----QCGRAFSQKQYLI----------K 181

  Fly   408 EQNDRDEQTPLKRKRSSELVFKQESSCPQPKTGRITDTVKSFQCHLCPVAFPTQKLLTRHHNTHI 472
            .||....:.|.|.....:...::|:.....   ||....|.::|..|..||..:..|.||..:|
Human   182 HQNIHTGKKPFKCSECGKAFSQKENLIIHQ---RIHTGEKPYECKGCGKAFIQKSSLIRHQRSH- 242

  Fly   473 KGLKSGKGGTLKCPSCALQLSCASSLKRHMIIHTGLKPFKCSECELSFSQREVLKRHMDTHTGVK 537
            .|.|     ...|..|....|..|:|..|..||.|.||:||:||...|.|::.|.:|.:.|||.|
Human   243 TGEK-----PYTCKECGKAFSGKSNLTEHEKIHIGEKPYKCNECGTIFRQKQYLIKHHNIHTGEK 302

  Fly   538 RHQCPQCSSCFAQKSNLQQHIGRVHMGNSRTHKCHLCHRSFNHVSGLSRHLVTHAGVM-FSCKQC 601
            .::|.:|...|::.::|..|: |:|.|: :.::|.:|.::|...|.|:.|:.:|.|.. :.|.:|
Human   303 PYECNKCGKAFSRITSLIVHV-RIHTGD-KPYECKVCGKAFCQSSSLTVHMRSHTGEKPYGCNEC 365

  Fly   602 GRQFNDRSAVQRHV 615
            |:.|:..|.:..|:
Human   366 GKAFSQFSTLALHM 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871
		vATP-synt_E	109..>244	CDD:304907
		RRF	<161..222	CDD:294170
		zf-C2H2_8	454..530	CDD:292531	27/75 (36%)
		C2H2 Zn finger	485..505	CDD:275368	6/19 (32%)
		zf-H2C2_2	497..522	CDD:290200	12/24 (50%)
		C2H2 Zn finger	513..533	CDD:275368	7/19 (37%)
		zf-H2C2_2	526..550	CDD:290200	9/23 (39%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	571..591	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..617	CDD:275368	6/18 (33%)
ZNF260	NP_001012774.1	COG5048	25..406	CDD:227381	79/274 (29%)
		C2H2 Zn finger	29..49	CDD:275368
		C2H2 Zn finger	57..77	CDD:275368
		C2H2 Zn finger	85..130	CDD:275368
		C2H2 Zn finger	138..158	CDD:275368	4/19 (21%)
		C2H2 Zn finger	166..186	CDD:275368	7/34 (21%)
		C2H2 Zn finger	194..214	CDD:275368	2/22 (9%)
		C2H2 Zn finger	222..242	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	6/19 (32%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	6/20 (30%)
		C2H2 Zn finger	334..354	CDD:275368	6/19 (32%)
		C2H2 Zn finger	362..382	CDD:275368	6/18 (33%)
		C2H2 Zn finger	390..410	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910