DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31365 and ZBTB11

DIOPT Version :9

Sequence 1:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_055230.2	Gene:	ZBTB11 / 27107	HGNCID:	16740	Length:	1053	Species:	Homo sapiens

Alignment Length:	736	Identity:	156/736 - (21%)
Similarity:	251/736 - (34%)	Gaps:	227/736 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 EHQDAYAIFDEDDTQLS-----IPVRLMACVALDAKAT--DTLPKRICQECRYQLEKSFLFRQRC 77
            |.:|..:.|....|..|     .||.....|.:|.|..  .:.||. ||....||.:..|..|.|
Human   151 ESEDDLSNFTSSPTTASKPAKKKPVSKHELVFVDTKGVVKRSSPKH-CQAVLKQLNEQRLSNQFC 214

  Fly    78 ------QWAEKKLRKHIRLLGLGKRSRVFSKDPDDYDED------------------------EL 112
                  :..|.|..|.:    |...|..|.   |.:.|.                        |.
Human   215 DVTLLIEGEEYKAHKSV----LSANSEYFR---DLFIEKGAVSSHEAVVDLSGFCKASFLPLLEF 272

  Fly   113 EFEDSIAF--------------------IEVQDKVRKLEDEKWREDFKEEQAAEMHKRLVKSRLE 157
            .:...::|                    :|:.:.|.||.:||....:|:.:.     :.|.|..:
Human   273 AYTSVLSFDFCSMADVAILARHLFMSEVLEICESVHKLMEEKQLTVYKKGEV-----QTVASTQD 332

  Fly   158 LRAK-------------LTTELRKELAE-EVRSEVRKELAEEVRSQVRDDLRNEVSEDIRKEQLA 208
            ||.:             .||.|..||.: |:...|..||.|..::
Human   333 LRVQNGGTAPPVASSEGTTTSLPTELGDCEIVLLVNGELPEAEQN-------------------- 377

  Fly   209 MLLGELEVYLTEKKAGRWESLDGSEPETKPQVKEDASPSRSKTKALPKRRPSLVDANLKATEARK 273
               ||:                |.:||  |||..:|..:.|....:....|.:...:|
Human   378 ---GEV----------------GRQPE--PQVSSEAESALSSVGCIADSHPEMESVDL------- 414

  Fly   274 DAKEEEFILGCNTDPANNSDVNIDGLELDEEVPAESGEDFREINMVGSDVVHTDNGEIYIINSAS 338
            ..|..:..|..:.:..||:..||......|.|.:.|.||    :.:|:|:              |
Human   415 ITKNNQTELETSNNRENNTVSNIHPKLSKENVISSSPED----SGMGNDI--------------S 461

  Fly   339 SEDQNQDSTPEF---------DQDNGITS-------------------YNIKEDGEIQFSG---- 371
            :||...:..|:.         ||:|.:.|                   .::.|...|:...
Human   462 AEDICAEDIPKHRQKVDQPLKDQENLVASTAKTDFGPDDDTYRSRLRQRSVNEGAYIRLHKGMEK 526

  Fly   372 --EKPEEIEDVVVFNLGEEISQEQQVFSFHENVIIVEKEQNDRDEQTPLKRKRSSE--LVFKQES 432
              :|.:.:....|..:.:::.|..:.         :::.:.|..|.|.....:..|  :||::..
Human   527 KLQKRKAVPKSAVQQVAQKLVQRGKK---------MKQPKRDAKENTEEASHKCGECGMVFQRRY 582

  Fly   433 SCPQPKTGRITDTVKSFQCHLCPVAFPTQKLLTRHHNTHIK-----------------GLKSGKG 480
            :....|...  :..:.::|.||...|.....|..|...|.:                 |..|.||
Human   583 ALIMHKLKH--ERARDYKCPLCKKQFQYSASLRAHLIRHTRKDAPSSSSSNSTSNEASGTSSEKG 645

  Fly   481 GTLK---CPSCALQLSCASSLKRHMIIHTGLKPFKCSECELSFSQREVLKRHMDTHTGVKRHQCP 542
            .|.:   |..|...|....||:.||:.|||:||..|..|..:|..:..||.|...|...|:.||.
Human   646 RTKREFICSICGRTLPKLYSLRIHMLKHTGVKPHACQVCGKTFIYKHGLKLHQSLHQSQKQFQCE 710

  Fly   543 QCSSCFAQKSNLQQHIGRVHMGNSRTHKCHLCHRSFNHVSGLSRHLVTH------AGVMFSCKQC 601
            .|...|..|.:||:|:. :|.|.|: :.|.:|.:||:..||||:|...|      .|  :.|.||
Human   711 LCVKSFVTKRSLQEHMS-IHTGESK-YLCSVCGKSFHRGSGLSKHFKKHQPKPEVRG--YHCTQC 771

  Fly   602 GRQFNDRSAVQRHVTTMHKVK 622
            .:.|.:...:::|:.....||
Human   772 EKSFFEARDLRQHMNKHLGVK 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871	21/78 (27%)
		vATP-synt_E	109..>244	CDD:304907	32/192 (17%)
		RRF	<161..222	CDD:294170	12/74 (16%)
		zf-C2H2_8	454..530	CDD:292531	27/95 (28%)
		C2H2 Zn finger	485..505	CDD:275368	7/19 (37%)
		zf-H2C2_2	497..522	CDD:290200	12/24 (50%)
		C2H2 Zn finger	513..533	CDD:275368	6/19 (32%)
		zf-H2C2_2	526..550	CDD:290200	9/23 (39%)
		C2H2 Zn finger	541..562	CDD:275368	7/20 (35%)
		C2H2 Zn finger	571..591	CDD:275368	9/19 (47%)
		C2H2 Zn finger	598..617	CDD:275368	5/18 (28%)
ZBTB11	NP_055230.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	141..173		5/21 (24%)
		BTB	204..305	CDD:279045	15/107 (14%)
		BTB	215..306	CDD:197585	11/97 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	546..566		4/28 (14%)
		C2H2 Zn finger	571..591	CDD:275368	4/19 (21%)
		C2H2 Zn finger	599..619	CDD:275368	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	619..643		2/23 (9%)
		C2H2 Zn finger	653..673	CDD:275368	7/19 (37%)
		zf-H2C2_2	665..690	CDD:290200	12/24 (50%)
		C2H2 Zn finger	681..701	CDD:275368	6/19 (32%)
		C2H2 Zn finger	709..729	CDD:275368	7/20 (35%)
		zf-H2C2_2	721..746	CDD:290200	10/26 (38%)
		C2H2 Zn finger	737..757	CDD:275368	9/19 (47%)
		C2H2 Zn finger	768..788	CDD:275368	5/19 (26%)
		zf-H2C2_2	780..804	CDD:290200	3/13 (23%)
		C2H2 Zn finger	796..816	CDD:275368
		C2H2 Zn finger	860..880	CDD:275368
		C2H2 Zn finger	888..908	CDD:275368
		zf-H2C2_2	900..923	CDD:290200
		C2H2 Zn finger	916..937	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000