DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31365 and ZNF285

DIOPT Version :9

Sequence 1:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001278417.1	Gene:	ZNF285 / 26974	HGNCID:	13079	Length:	597	Species:	Homo sapiens

Alignment Length:	601	Identity:	138/601 - (22%)
Similarity:	220/601 - (36%)	Gaps:	191/601 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 LEFEDSIAFIEVQDKVRKLEDEKWREDFKEEQAAEMHKRLVKSRLELRAKLTTELRKELAEE--- 173
            ::|:  |..|.||::|          .||:....     ..|..|.|..|....|.:::..|
Human     2 IKFQ--IQGIHVQERV----------TFKDVAVV-----FTKEELALLDKAQINLYQDVMLENFR 49

  Fly   174 ----VRSEVRKE-----------LAEEV-------RSQVRD---------DLRNEVSEDIRKEQL 207
                ||..::..           |::||       :.::||         :|:.|.|..:.
Human    50 NLMLVRDGIKNNILNLQAKGLSYLSQEVLHCWQIWKQRIRDLTVSQDYIVNLQEECSPHLE---- 110

  Fly   208 AMLLGELEVYLTEKKAGRWESLDGSEPE---TKPQVK-EDASPSRSKTKALPKRRPSLVDANLKA 268
                   :|.|:|:.||  .||..||.|   ....:| :|.:..:|.|:.|...  |...||:.
Human   111 -------DVSLSEEWAG--ISLQISENENYVVNAIIKNQDITAWQSLTQVLTPE--SWRKANIM- 163

  Fly   269 TEARKDAKEEEFILGCNTDPANNSDVNIDGLELDEEVPAESGEDFREINMVGSDVVHTDNGEIYI 333
                             |:| .||.....|:.::|::...:..| ..::....|  |.::.|
Human   164 -----------------TEP-QNSQGRYKGIYMEEKLYRRAQHD-DSLSWTSCD--HHESQE--- 204

  Fly   334 INSASSEDQNQ----------DSTPE-----------FDQDNGITSYNIKEDGEIQFS---GEKP 374
               ...||..:          .||.|           |..:|...::....|..:..|   |||.
Human   205 ---CKGEDPGRHPSCGKNLGMKSTVEKRNAAHVLPQPFPCNNCGVAFADDTDPHVHHSTHLGEKS 266

  Fly   375 EEIEDVVVFNLGEEISQEQQV------------FSFHENVIIVEKEQNDRDEQTPLKRKRSSELV 427
            .:.:     ..|:..||.|.:            :.|||               .|:..|:||:|
Human   267 YKCD-----QYGKNFSQSQDLIVHCKTHSGKTPYEFHE---------------WPMGCKQSSDL- 310

  Fly   428 FKQESSCPQPKTGRITDTVKSFQCHLCPVAFPTQKLLTRHHNTHI-------------------- 472
                     |:..:::...|.::|..|...|.....|..||..|.
Human   311 ---------PRYQKVSSGDKPYKCKECGKGFRRSSSLHNHHRVHTGEMPYKCDECGKGFGFRSLL 366

  Fly   473 ---KGLKSGKGGTLKCPSCALQLSCASSLKRHMIIHTGLKPFKCSECELSFSQREVLKRHMDTHT 534
               :|:.:|| ...||..|......:|:|..|..:|||.||:|||||...||...||:.|...||
Human   367 CIHQGVHTGK-KPYKCEECGKGFDQSSNLLVHQRVHTGEKPYKCSECGKCFSSSSVLQVHWRFHT 430

  Fly   535 GVKRHQCPQCSSCFAQKSNLQQHIGRVHMGNSRTHKCHLCHRSFNHVSGLSRHLVTHAGVM-FSC 598
            |.|.::|.:|...|:|.::|..| .|||.| .:.:||::|.:.|.:.|.|..|...|.|.. :.|
Human   431 GEKPYRCGECGKGFSQCTHLHIH-QRVHTG-EKPYKCNVCGKDFAYSSVLHTHQRVHTGEKPYKC 493

  Fly   599 KQCGRQFNDRSAVQRH 614
            :.||:.|:..|....|
Human   494 EVCGKCFSYSSYFHLH 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871
		vATP-synt_E	109..>244	CDD:304907	35/169 (21%)
		RRF	<161..222	CDD:294170	16/94 (17%)
		zf-C2H2_8	454..530	CDD:292531	29/98 (30%)
		C2H2 Zn finger	485..505	CDD:275368	5/19 (26%)
		zf-H2C2_2	497..522	CDD:290200	13/24 (54%)
		C2H2 Zn finger	513..533	CDD:275368	9/19 (47%)
		zf-H2C2_2	526..550	CDD:290200	9/23 (39%)
		C2H2 Zn finger	541..562	CDD:275368	7/20 (35%)
		C2H2 Zn finger	571..591	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..617	CDD:275368	6/17 (35%)
ZNF285	NP_001278417.1	KRAB	15..54	CDD:279668	9/53 (17%)
		KRAB	15..>52	CDD:214630	9/51 (18%)
		C2H2 Zn finger	214..233	CDD:275368	3/18 (17%)
		COG5048	236..569	CDD:227381	81/307 (26%)
		C2H2 Zn finger	241..261	CDD:275368	3/19 (16%)
		C2H2 Zn finger	269..289	CDD:275368	4/24 (17%)
		zf-C2H2	323..345	CDD:278523	6/21 (29%)
		C2H2 Zn finger	325..345	CDD:275368	6/19 (32%)
		C2H2 Zn finger	353..373	CDD:275368	1/19 (5%)
		C2H2 Zn finger	381..401	CDD:275368	5/19 (26%)
		zf-H2C2_2	393..418	CDD:290200	13/24 (54%)
		C2H2 Zn finger	409..429	CDD:275368	9/19 (47%)
		C2H2 Zn finger	437..457	CDD:275368	7/20 (35%)
		zf-H2C2_2	453..474	CDD:290200	9/22 (41%)
		C2H2 Zn finger	465..485	CDD:275368	6/19 (32%)
		zf-H2C2_2	480..502	CDD:290200	7/21 (33%)
		C2H2 Zn finger	493..513	CDD:275368	6/17 (35%)
		zf-C2H2	519..541	CDD:278523
		C2H2 Zn finger	521..541	CDD:275368
		zf-H2C2_2	533..558	CDD:290200
		C2H2 Zn finger	549..569	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100