DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31365 and ZBTB43

DIOPT Version :9

Sequence 1:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001129248.1	Gene:	ZBTB43 / 23099	HGNCID:	17908	Length:	467	Species:	Homo sapiens

Alignment Length:	385	Identity:	83/385 - (21%)
Similarity:	133/385 - (34%)	Gaps:	114/385 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 AEEVRSQVRDDLRNEVSEDIRKEQLAMLLGELEVYLTEKKAGRWESLDGSEPETKPQVKEDASPS 247
            |:|:|     |..||  |:..|::|:..|.|.| ||....:...:.|      :.....:|....
Human   168 AQELR-----DGENE--EESTKDELSSQLTEHE-YLPSNSSTEHDRL------STEMASQDGEEG 218

  Fly   248 RSKTKALPKRRPSLVDANLKATEARKDAKEEEFILGCNTDPANNSDVNIDGLEL----DEEVPAE 308
            .|.:......||.....::.|.:.....|.|.....|            :|:::    ||....|
Human   219 ASDSAEFHYTRPMYSKPSIMAHKRWIHVKPERLEQAC------------EGMDVHATYDEHQVTE 271

  Fly   309 SGEDFREINMVGSDVVHTDNG--EIYIINSASSEDQNQDSTPEFDQDNGITSYNIKEDGEIQFSG 371
            |      ||.|.::.....:|  |.:.|.....|.:..:...|.:.|..:..|....:   :|||
Human   272 S------INTVQTEHTVQPSGVEEDFHIGEKKVEAEFDEQADESNYDEQVDFYGSSME---EFSG 327

  Fly   372 EKPEEIEDVVVFNLGEEISQEQQ---VFSFHENVIIVEKEQNDRDEQTPLKRKRSSELVFKQESS 433
            |:.:          |..|...|:   ...:.||:.:|          |.:| :.:|.|.|.
Human   328 ERSD----------GNLIGHRQEAALAAGYSENIEMV----------TGIK-EEASHLGFS---- 367

  Fly   434 CPQPKTGRITDTVKSFQCHLCPVAFPTQKLLTRHHNTHIKGLKSGKGGTLKCPSCALQLSCASSL 498
                    .||.:...||                          ||..|.|           |..
Human   368 --------ATDKLYPCQC--------------------------GKSFTHK-----------SQR 387

  Fly   499 KRHMIIHTGLKPFKCSECELSFSQREVLKRHMDTHTGVKRHQCPQCSSCFAQKSNLQQHI 558
            .|||.:|.||:|:.|..|...|..:..|..||..|||:|.::|..|:..|..:.:..:|:
Human   388 DRHMSMHLGLRPYGCGVCGKKFKMKHHLVGHMKIHTGIKPYECNICAKRFMWRDSFHRHV 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871
		vATP-synt_E	109..>244	CDD:304907	15/60 (25%)
		RRF	<161..222	CDD:294170	14/38 (37%)
		zf-C2H2_8	454..530	CDD:292531	16/75 (21%)
		C2H2 Zn finger	485..505	CDD:275368	4/19 (21%)
		zf-H2C2_2	497..522	CDD:290200	10/24 (42%)
		C2H2 Zn finger	513..533	CDD:275368	6/19 (32%)
		zf-H2C2_2	526..550	CDD:290200	10/23 (43%)
		C2H2 Zn finger	541..562	CDD:275368	4/18 (22%)
		C2H2 Zn finger	571..591	CDD:275368
		C2H2 Zn finger	598..617	CDD:275368
ZBTB43	NP_001129248.1	BTB_POZ_ZBTB43	8..128	CDD:349536
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..153
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..225		17/70 (24%)
		C2H2 Zn finger	376..394	CDD:275368	10/54 (19%)
		C2H2 Zn finger	402..422	CDD:275368	6/19 (32%)
		zf-H2C2_2	414..437	CDD:404364	9/22 (41%)
		C2H2 Zn finger	430..447	CDD:275368	3/16 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000