DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31365 and Zfp719

DIOPT Version :9

Sequence 1:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001344698.1	Gene:	Zfp719 / 210105	MGIID:	2444708	Length:	735	Species:	Mus musculus

Alignment Length:	673	Identity:	144/673 - (21%)
Similarity:	241/673 - (35%)	Gaps:	211/673 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 IAFIEVQDKVRKLEDEKWREDFKEEQAAEMHKRLVKSRLELRAKLTTELRKELAEEVRS--EVRK 180
            :.:::..:|:|    |:.|.:..|:...:|      :..::..:|..|.:..|.|.:.|  :|..
Mouse     2 LTYLQNPEKIR----ERPRVETTEDMPTDM------NFCQMPQQLGAEEQDGLCERLVSFDDVTV 56

  Fly   181 ELAEEVRSQVRDDLRNEVSEDIRKEQLAMLL--GELEV------------YLTE--KKAGRWESL 229
            :.::| ..|..|..:..:.:|:..|..:.||  |:|::            :|::  .:..:..|:
Mouse    57 DFSQE-EWQHLDSAQRRLYQDVMLEIYSHLLSVGKLQLDTQHQQIFVKASFLSDAASEVTKHGSI 120

  Fly   230 DGSEPETKPQVKEDASPSRSKTKALPKRRPSLVDANLKATEARKDAKE-EEFIL----------- 282
            ..|..|...|..:.|:.:..:::.||....:..:..:....:..|.:| ||..|
Mouse   121 YCSVLEKLWQEGDPAAKTDQQSRVLPVSPGAFQNQKILTIGSAWDYEETEESTLLEPHLISTQYV 185

  Fly   283 --GCNTDPANNSDVNIDGLELDEE------------VPAESGEDF-----------------REI 316
              ..|:|..:|:...::.:...::            ||.::.:.:                 .||
Mouse   186 PPRANSDSQSNTIKQLNDIIGSDQFFTQASSNGVCTVPHQTEKPYTESQFGNIVSLNPPLMDHEI 250

  Fly   317 NMVGSDVVHTDNGEIY----------IINS--------------------ASSEDQNQDSTPEFD 351
            |.....|.:|..|:::          |.||                    .|..:..::.||...
Mouse   251 NFQDKPVEYTGCGKVFTGETAFCQQQITNSMETSFICHTCGKTFLHKSKLTSHSETPREETPYEC 315

  Fly   352 QD-----NGITSYNI------KED-------GEIQFS-------------GEKPEEIEDVVVFNL 385
            .|     .|.||..:      ||.       |: .||             ||||....|     .
Mouse   316 PDCAKSLRGTTSLQVLRGVQTKEKPYECHVCGK-SFSYTSHLKVHLRTHTGEKPYACSD-----C 374

  Fly   386 GEEISQEQQVFSFHENVIIVEKEQNDRD---------EQTPLKRKRSSELVFKQESSCP------ 435
            |:..|| :.|.:.|:.:...||.....|         :.|...|..:.|..::    ||
Mouse   375 GKAFSQ-KSVLTIHQRIHTGEKPYTCSDCGKMFVCASDLTKHCRFHTGEKPYE----CPDCGKSF 434

  Fly   436 --------------------------------------QPKTGRITDTVKSFQCHLCPVAFPTQK 462
                                                  |..|.|     :||.|..|.:||..:.
Mouse   435 SIKSNLLAHHRIHTSEGPYKCFHCGESFRKISQLKVHHQIHTDR-----RSFVCSDCGMAFSQKS 494

  Fly   463 LLTRHHNTHIKGLKSGKGGTLKCPSCALQLSCASSLKRHMIIHTGLKPFKCSECELSFSQREVLK 527
            :||.|...|     ||: ....|..|......||.||:|...|||.||:||.:|..|:|.:..|.
Mouse   495 VLTTHQRIH-----SGE-KCYPCSDCGKLFLYASDLKKHCRFHTGEKPYKCHDCGKSYSVKSHLH 553

  Fly   528 RHMDTHTGVKRHQCPQCSSCFAQKSNLQQHIGRVHMGNSRTHKCHLCHRSFNHVSGLSRHLVTHA 592
            .|...|||.:.::|..|...|.:.|:||.| .:.|.| .:.:||..|.:||...|.|..|...|.
Mouse   554 VHHRIHTGERPYKCDDCGKSFRRNSHLQMH-QQTHTG-EKPYKCSDCGKSFRRASHLKVHHRIHT 616

  Fly   593 GVM-FSCKQCGRQFNDRSAVQRH 614
            |.. |.|.:||:.|||||.:..|
Mouse   617 GEKPFVCSECGKAFNDRSVLSTH 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871
		vATP-synt_E	109..>244	CDD:304907	26/143 (18%)
		RRF	<161..222	CDD:294170	16/78 (21%)
		zf-C2H2_8	454..530	CDD:292531	27/75 (36%)
		C2H2 Zn finger	485..505	CDD:275368	7/19 (37%)
		zf-H2C2_2	497..522	CDD:290200	12/24 (50%)
		C2H2 Zn finger	513..533	CDD:275368	6/19 (32%)
		zf-H2C2_2	526..550	CDD:290200	8/23 (35%)
		C2H2 Zn finger	541..562	CDD:275368	7/20 (35%)
		C2H2 Zn finger	571..591	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..617	CDD:275368	9/17 (53%)
Zfp719	NP_001344698.1	KRAB	48..89	CDD:396083	9/41 (22%)
		C2H2 Zn finger	287..307	CDD:275368	1/19 (5%)
		C2H2 Zn finger	315..335	CDD:275368	4/19 (21%)
		COG5048	335..708	CDD:227381	89/329 (27%)
		C2H2 Zn finger	343..363	CDD:275368	3/20 (15%)
		C2H2 Zn finger	371..391	CDD:275368	6/25 (24%)
		C2H2 Zn finger	399..419	CDD:275368	3/19 (16%)
		C2H2 Zn finger	427..447	CDD:275368	2/19 (11%)
		C2H2 Zn finger	455..475	CDD:275368	1/19 (5%)
		C2H2 Zn finger	483..503	CDD:275368	7/19 (37%)
		C2H2 Zn finger	511..531	CDD:275368	7/19 (37%)
		C2H2 Zn finger	539..559	CDD:275368	6/19 (32%)
		C2H2 Zn finger	567..587	CDD:275368	7/20 (35%)
		C2H2 Zn finger	595..615	CDD:275368	7/19 (37%)
		C2H2 Zn finger	623..643	CDD:275368	9/17 (53%)
		C2H2 Zn finger	651..671	CDD:275368
		C2H2 Zn finger	679..699	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000