Protein Alignment CG31365 and ZNF782

DIOPT Version :10

• Sequence 1: NP_732827.1
• Gene: CG31365 / 42736
• FlyBaseID: FBgn0051365
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_001001662.1
• Gene: ZNF782 / 158431
• HGNCID: 33110
• Length: 699
• Species: Homo sapiens
• Alignment Length: 617
• Identity: 151/617 - (24%)
• Similarity: 222/617 - (35%)
• Gaps: 174/617 - (28%)

  Fly   114 FEDSIAFIEVQDKVRKLEDEKWREDFKEEQA------AEMHKRLVK-----SRLELRAKLTTELR 167
            |:.|::|   ||...:...|:|:.....|:.      .|.:..||.     ::.||...|.....
Human     4 FQASVSF---QDVTVEFSQEEWQHMGPVERTLYRDVMLENYSHLVSVGYCFTKPELIFTLEQGED 65

  Fly   168 KELAEEVRSEVRKELAEEVRSQVRDDLRNEVSEDIRKEQLAMLLGELEVYLTEKKAGRWESLDGS 232
            ..|.|       ||.....|:...|...:|:||...:.|...|   |:|..|.|.....:.:.|
Human    66 PWLLE-------KEKGFLSRNSPEDSQPDEISEKSPENQGKHL---LQVLFTNKLLTTEQEISG- 119

  Fly   233 EPETKPQVKE-----------DASPSRSKTKALPKRRPSLVDANLKATE-------------ARK 273
                ||..::           ....:.|..:.|....|....:..||.|             .|.
Human   120 ----KPHNRDINIFRARMMPCKCDIAGSACQGLSLMAPHCQYSKEKAHERNVCDKWLISIKDGRT 180

  Fly   274 DAKEEEFILGCNTDPANNSDVNIDGLELDEEVPAES-----GEDFREIN-----------MVGSD 322
            :.:|:.|..         |.: :..|...|||....     |:|| |.|           :|.|:
Human   181 NTQEKSFAY---------SKI-VKTLHHKEEVIQHQTIQTLGQDF-EYNESRKAFLEKAALVTSN 234

  Fly   323 VVHTDNGEIYIINSASSEDQN-------QDSTPEFD----QDNG-----IT------------SY 359
            ..| ..|:.|..|.......:       |:..||..    .|.|     ||            ..
Human   235 STH-PKGKSYNFNKFGENKYDKSTFIIPQNMNPEKSHYEFNDTGNCFCRITHKTLTGGKSFSQKS 298

  Fly   360 NIKEDGEIQFSGEKPEEIEDVVVFNLGEEISQE---------------------------QQVFS 397
            :|:|...:.. |.||        |..|:..::.                           |..||
Human   299 HIREHHRVHI-GVKP--------FEYGKSFNRNSTLPVHQRTHATDKYSDYHPCTETFSYQSTFS 354

  Fly   398 FHENVIIVEK--EQNDRDEQTPLKRKRSSELVFKQESSCPQPKTGRITDTVKSFQCHLCPVAFPT 460
            .|:.|.|..|  |.|:..:...:    :|.|::.|:|     .||.     |.::|..|..||..
Human   355 VHQKVHIRAKPYEYNECGKSCSM----NSHLIWPQKS-----HTGE-----KPYECPECGKAFSE 405

  Fly   461 QKLLTRHHNTHIKGLKSGKGGTLKCPSCALQLSCASSLKRHMIIHTGLKPFKCSECELSFSQREV 525
            :..|.:|..|| .|.|     ..||..|....|..|.|:.|...|||.|||:|.||..||:.:.:
Human   406 KSRLRKHQRTH-TGEK-----PYKCDGCDKAFSAKSGLRIHQRTHTGEKPFECHECGKSFNYKSI 464

  Fly   526 LKRHMDTHTGVKRHQCPQCSSCFAQKSNLQQHIGRVHMGNSRTHKCHLCHRSFNHVSGLSRHLVT 590
            |..|..||||.|..:|.:|...|:..|.|:.| .|.|.| .|.:||..|.::|...|||.:|..|
Human   465 LIVHQRTHTGEKPFECNECGKSFSHMSGLRNH-RRTHTG-ERPYKCDECGKAFKLKSGLRKHHRT 527

  Fly   591 HAGVM-FSCKQCGRQFNDRSAVQRHVTTMHKV 621
            |.|.. :.|.|||:.|..:|.::.|    |::
Human   528 HTGEKPYKCNQCGKAFGQKSQLRGH----HRI 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871
		PTZ00121	<110..354	CDD:173412	60/301 (20%)
		zf-C2H2_8	454..542	CDD:464935	34/87 (39%)
		C2H2 Zn finger	485..505	CDD:275368	6/19 (32%)
		zf-H2C2_2	497..522	CDD:463886	13/24 (54%)
		C2H2 Zn finger	513..533	CDD:275368	7/19 (37%)
		zf-H2C2_2	526..550	CDD:463886	10/23 (43%)
		C2H2 Zn finger	541..562	CDD:275368	7/20 (35%)
		C2H2 Zn finger	571..591	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..617	CDD:275368	7/18 (39%)
ZNF782	NP_001001662.1	KRAB	8..67	CDD:214630	12/61 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	75..95		5/19 (26%)
		C2H2 Zn finger	291..307	CDD:275368	2/15 (13%)
		C2H2 Zn finger	314..332	CDD:275368	1/17 (6%)
		C2H2 Zn finger	343..360	CDD:275368	4/16 (25%)
		C2H2 Zn finger	369..388	CDD:275368	5/27 (19%)
		COG5048	392..697	CDD:227381	65/176 (37%)
		C2H2 Zn finger	396..416	CDD:275368	6/19 (32%)
		C2H2 Zn finger	424..444	CDD:275368	6/19 (32%)
		C2H2 Zn finger	452..472	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	7/20 (35%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	536..556	CDD:275368	8/24 (33%)
		C2H2 Zn finger	564..584	CDD:275368
		C2H2 Zn finger	592..612	CDD:275368
		C2H2 Zn finger	620..640	CDD:275368
		C2H2 Zn finger	648..668	CDD:275368
		C2H2 Zn finger	676..696	CDD:275368