DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31365 and ZNF534

DIOPT Version :9

Sequence 1:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001137411.1	Gene:	ZNF534 / 147658	HGNCID:	26337	Length:	674	Species:	Homo sapiens

Alignment Length:	529	Identity:	124/529 - (23%)
Similarity:	199/529 - (37%)	Gaps:	145/529 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 VRSEVR-------KELAEEVRSQVRDDLRNEVSEDIRKEQLAMLLGELEVYLTEKKAGRWESLDG 231
            ::|||:       :|..:.|.::....|.:.......|.|..:   .|:::|||     |:....
Human    82 LQSEVKIINNPDGRECIKGVNTEKSSKLGSSAGNKSLKNQHGL---TLQLHLTE-----WQPFQA 138

  Fly   232 SE-----PETKPQVKEDASPS-------RSKTKALPKRRPSLVDANLKATEARKDAKEEEFILGC 284
            ..     ...:..:.:::|.|       ..||......|...:.:.|...|.:...:|:.:  ||
Human   139 VRNIYGCKHVEKSISDNSSVSPVQISFFSVKTHIFNNYRNDFLFSTLLPQEQKVHIREKPY--GC 201

  Fly   285 NTDPANNSDVNIDGLELDEEVPAESGEDFR-EINMVGSDVVH--------TDNGEIYIINSASSE 340
            |                      |.|:.|| ..::....|:|        :|.|||:..||..::
Human   202 N----------------------EHGKVFRVSSSLTNRQVIHIADKTYKCSDCGEIFSSNSNFAQ 244

  Fly   341 DQ------------------NQDSTPEFDQ--DNGITSYNIKEDGEIQFS-------------GE 372
            .|                  ||:|.....|  ..|...||.||.|:: ||             ||
Human   245 HQRIHTGEKPYKYNECGKVFNQNSHLAQHQKIHTGQKPYNNKECGKV-FSHHAYLAQHRKIHTGE 308

  Fly   373 KPEEIEDV-------------VVFNLGE---------EISQEQQVFSFHENVIIVEKEQNDRDEQ 415
            ||.:..:.             :|.:.||         ::.:.:...:.|:.|...|:
Human   309 KPYKCSECGKAFSVCSSLTAHLVIHTGEKPYDCKECGKVFRHKSSLTTHQTVHTGER-------- 365

  Fly   416 TPLK----RKRSSELVFKQESSCPQPKTGRITDTVKSFQCHLCPVAFPTQKLLTRHHNTHIKGLK 476
             |.|    .|..|.:.|.....  :..||.     |.::|:.|...|.....|.||...|..|.:
Human   366 -PYKCNECGKGFSRIAFLARHR--KVHTGE-----KPYKCNECGKVFIGNSRLARHRKIHTGGRR 422

  Fly   477 SGKGGTLKCPSCALQLSCASSLKRHMIIHTGLKPFKCSECELSFSQREVLKRHMDTHTGVKRHQC 541
                  .||..|.......|.|..|::||||.||::|.:|...|..:..|..|...|||.|.::|
Human   423 ------YKCNECGKAFRTCSDLTAHLLIHTGEKPYECIDCGKVFRHKSSLTYHCRIHTGEKPYKC 481

  Fly   542 PQCSSCFAQKSNLQQHIGRVHMGNSRTHKCHLCHRSFNHVSGLSRHLVTHAGVM-FSCKQCGRQF 605
            .:|...|:|.||||:| .::|.| .:.:||:.|.:.|...|.|::|...|.|.. :||.:||:.|
Human   482 NECGKVFSQNSNLQRH-RKIHTG-EKLYKCNECGKVFRQNSHLAQHRDIHTGEKPYSCNECGKVF 544

  Fly   606 NDRSAVQRH 614
            ...|.:.||
Human   545 RRNSHLVRH 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871
		vATP-synt_E	109..>244	CDD:304907	13/81 (16%)
		RRF	<161..222	CDD:294170	12/54 (22%)
		zf-C2H2_8	454..530	CDD:292531	23/75 (31%)
		C2H2 Zn finger	485..505	CDD:275368	5/19 (26%)
		zf-H2C2_2	497..522	CDD:290200	11/24 (46%)
		C2H2 Zn finger	513..533	CDD:275368	5/19 (26%)
		zf-H2C2_2	526..550	CDD:290200	9/23 (39%)
		C2H2 Zn finger	541..562	CDD:275368	9/20 (45%)
		C2H2 Zn finger	571..591	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..617	CDD:275368	7/17 (41%)
ZNF534	NP_001137411.1	KRAB	8..81	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	201..221	CDD:275368	7/41 (17%)
		COG5048	211..609	CDD:227381	96/368 (26%)
		C2H2 Zn finger	229..249	CDD:275368	7/19 (37%)
		zf-H2C2_2	241..266	CDD:290200	1/24 (4%)
		C2H2 Zn finger	258..277	CDD:275368	4/18 (22%)
		C2H2 Zn finger	286..305	CDD:275368	5/19 (26%)
		zf-H2C2_2	297..321	CDD:290200	4/23 (17%)
		C2H2 Zn finger	313..333	CDD:275368	1/19 (5%)
		C2H2 Zn finger	341..361	CDD:275368	1/19 (5%)
		zf-H2C2_2	353..378	CDD:290200	6/33 (18%)
		C2H2 Zn finger	369..389	CDD:275368	3/21 (14%)
		zf-H2C2_2	382..404	CDD:290200	5/28 (18%)
		C2H2 Zn finger	397..417	CDD:275368	6/19 (32%)
		C2H2 Zn finger	425..445	CDD:275368	5/19 (26%)
		C2H2 Zn finger	453..473	CDD:275368	5/19 (26%)
		zf-H2C2_2	465..490	CDD:290200	9/24 (38%)
		C2H2 Zn finger	481..501	CDD:275368	9/20 (45%)
		zf-H2C2_2	493..518	CDD:290200	10/26 (38%)
		C2H2 Zn finger	509..529	CDD:275368	6/19 (32%)
		zf-H2C2_2	521..546	CDD:290200	9/24 (38%)
		C2H2 Zn finger	537..557	CDD:275368	7/17 (41%)
		zf-H2C2_2	549..574	CDD:290200	2/5 (40%)
		C2H2 Zn finger	565..585	CDD:275368
		zf-H2C2_2	577..602	CDD:290200
		C2H2 Zn finger	593..613	CDD:275368
		zf-H2C2_2	605..630	CDD:290200
		C2H2 Zn finger	621..641	CDD:275368
		C2H2 Zn finger	649..669	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910