DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31365 and Zkscan16

DIOPT Version :9

Sequence 1:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001092793.1	Gene:	Zkscan16 / 100041581	MGIID:	3510405	Length:	728	Species:	Mus musculus

Alignment Length:	635	Identity:	152/635 - (23%)
Similarity:	221/635 - (34%)	Gaps:	180/635 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 VFSKDPDDYDEDELEFED-SIAFIEVQDKVRKLEDEKWREDFKEEQAAEMHKRLV---------- 152
            |....||....:.:.||| |:.|          ...:|:  ..|....|::|.::
Mouse   157 VVMASPDPEPRESVTFEDVSVDF----------SRGEWK--LLEPSQRELYKEVLLENLGTLEFL 209

  Fly   153 ---KSRLELRA-----KLTTELRKELAEEVR-------SEVRKE---------LAEEVRSQVRD- 192
               .|:|:|.:     ||...|.||:.::.|       ||.|:|         |.:.|....||
Mouse   210 GSPVSKLDLISHLKWVKLPRVLEKEILKDPRPGELVKESESRRELDAFMEGLTLEKTVEYCFRDG 274

  Fly   193 --DLRNEVSEDIRKEQLAMLLGELEVYLTEKKAGRWESLDGSEPETK-----PQVKEDAS----- 245
              .|:.|......|              .:|..|:..|.:..|.||:     .:||:.:.
Mouse   275 GYGLKTEFQRRHGK--------------PKKDHGKRSSHENRESETEGTSSGKRVKQTSDTLKHR 325

  Fly   246 -------PSRSKT--------KALPKRRPSLVDANLKATEARKDAKEEEFILGCNTDPANNSDVN 295
                   ..|||.        .||..||....:.:.|..|..||.:.       :..||......
Mouse   326 KASLSKMSQRSKEGKKPFSFHSALVNRRELRREKSRKCGEPEKDPRR-------HLSPAERKRHP 383

  Fly   296 IDGLELDEEVPAESGEDFREI--NMVGSDVVHTDNGEIYIINSASSEDQNQDSTPEFDQ------ 352
            ..|.....|..::.|..|.:|  |.:.|.........::     ..|..|||..|:.::
Mouse   384 KIGSLSKTETCSKCGVAFTQILENCIESSQCEKCRKNLF-----QDEAPNQDKEPDPEEASKCGK 443

  Fly   353 ---------------------------------DNGITSYNIKEDG----EIQF--------SGE 372
                                             |.....|...|.|    |:.|        :||
Mouse   444 CGKAFEPGTKRSVCLECRKAPKASASPKPHNKADRKEKRYKCDECGKRFAELYFLTHHQRTHTGE 508

  Fly   373 KPEEIEDVVVFNLGEEISQEQQVFSFHENVIIVEKEQNDRDEQTPLKRKRSSELVFKQESSCPQP 437
            ||     .|..:.|...| :...|..|:.:...||         |...|...: .|...||.  .
Mouse   509 KP-----YVCKHCGRPFS-DYSSFYQHQRIHTGEK---------PYTCKECGK-SFTHSSSL--S 555

  Fly   438 KTGRITDTVKSFQCHLCPVAFPTQKLLTRHHNTHIKGLKSGKGGTLKCPSCALQLSCASSLKRHM 502
            |..||....|.::|:.|..||.....||||...|     :|:...| |..|.|.....||:..|.
Mouse   556 KHQRIHTGEKPYKCNECGKAFRQNSCLTRHQKIH-----TGEKPFL-CKDCGLSFRLFSSIMYHQ 614

  Fly   503 IIHTGLKPFKCSECELSFSQREVLKRHMDTHTGVKRHQCPQCSSCFAQKSNLQQHIGRVHMGNSR 567
            .:|.|.||:||:.||..|.....|.||:..|||.|.::|.:|...|.|.|:|..|| |.|.| .:
Mouse   615 RLHAGEKPYKCTHCEKGFPSHSRLSRHLRCHTGAKPYKCKECGKTFRQSSSLNLHI-RTHTG-EK 677

  Fly   568 THKCHLCHRSFNHVSGLSRHLVTHAGVMFSCKQCGRQFNDRSAVQRHVTT 617
            .:||..|..:|...:.|..|:.||..|.:.||:||:.|..|:...:|..|
Mouse   678 PYKCDYCGAAFTRSTILIEHVKTHTNVQYECKKCGKTFKSRTTSLKHHCT 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871
		vATP-synt_E	109..>244	CDD:304907	37/177 (21%)
		RRF	<161..222	CDD:294170	17/79 (22%)
		zf-C2H2_8	454..530	CDD:292531	27/75 (36%)
		C2H2 Zn finger	485..505	CDD:275368	6/19 (32%)
		zf-H2C2_2	497..522	CDD:290200	11/24 (46%)
		C2H2 Zn finger	513..533	CDD:275368	7/19 (37%)
		zf-H2C2_2	526..550	CDD:290200	10/23 (43%)
		C2H2 Zn finger	541..562	CDD:275368	9/20 (45%)
		C2H2 Zn finger	571..591	CDD:275368	5/19 (26%)
		C2H2 Zn finger	598..617	CDD:275368	7/18 (39%)
Zkscan16	NP_001092793.1	SCAN	45..132	CDD:366881
		KRAB	170..223	CDD:214630	12/64 (19%)
		PRK07219	<383..489	CDD:235971	15/110 (14%)
		C2H2 Zn finger	457..477	CDD:275368	0/19 (0%)
		COG5048	<462..608	CDD:227381	40/169 (24%)
		C2H2 Zn finger	485..505	CDD:275368	4/19 (21%)
		C2H2 Zn finger	513..533	CDD:275368	4/20 (20%)
		COG5048	<537..725	CDD:227381	69/207 (33%)
		C2H2 Zn finger	541..561	CDD:275368	6/22 (27%)
		C2H2 Zn finger	569..589	CDD:275368	8/19 (42%)
		C2H2 Zn finger	597..617	CDD:275368	6/19 (32%)
		C2H2 Zn finger	625..645	CDD:275368	7/19 (37%)
		C2H2 Zn finger	653..673	CDD:275368	9/20 (45%)
		C2H2 Zn finger	681..701	CDD:275368	5/19 (26%)
		C2H2 Zn finger	708..725	CDD:275368	6/16 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910