DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31365 and zgc:171422

DIOPT Version :9

Sequence 1:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001107944.2	Gene:	zgc:171422 / 100001353	ZFINID:	ZDB-GENE-080204-95	Length:	717	Species:	Danio rerio

Alignment Length:	614	Identity:	144/614 - (23%)
Similarity:	229/614 - (37%)	Gaps:	177/614 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 EQAAEMHKRLVKSRLELRAKLTTELRKELAEEVRSEVRKELAEEVRSQVRDDLRN---------- 196
            |..|::|  .|||.::  ...||:|.|....::.| ::..:.:.|.|.:.|.::.
Zfish    78 ELPADLH--TVKSHID--QIQTTDLLKVSDTDMES-LQDSVLQLVLSLLEDAMKREYFFQEVFPV 137

  Fly   197 EVSEDIRK----------------------EQLAMLL----GELEVYLTEK-KAGRWESLDGS-- 232
            |...|..|                      :||::||    |||:.|:... |:....||..|
Zfish   138 EYGPDFDKALQVLVGFFLSRLEQLLPVPNFKQLSLLLSCRPGELDGYVDSVCKSHSLLSLLQSDI 202

  Fly   233 ----EPETKPQVKEDASPSRSKTKALPKRRPSLV-----DANLKATEAR---KDAKEEEFILGCN 285
                |....|.:.||...|   :.:||....|::     ||.|...|.:   |...::|.:.|
Zfish   203 CGTLEKNVLPSIVEDRIVS---SLSLPPVGDSVLVNQQNDATLLLEEPKNLLKQTVDKETLAG-- 262

  Fly   286 TDP-------ANNSDVNIDGLELDEEVPAESGEDFREINMVGSDVVHTDN----GEIYIINSASS 339
             ||       ::||:.:....:.::|..|   ::.:|.|....|::.:.|    |:  :|..|::
Zfish   263 -DPDVRNEGSSSNSESSFRDSDGEKETNA---DELQECNSKEPDLLSSTNDAHTGD--LIFPAAA 321

  Fly   340 EDQNQDS---TPE---------FDQDNGITSYNI-KED-GEIQFSGEKP---------EEIEDVV 381
            ..|..||   :|.         ..:....|.|.| :.| .:.|.:..||         ::.||..
Zfish   322 PPQRPDSFTNSPSKGFHYAGRTVHRCQQCTKYFIYRSDLAKHQETHTKPGAHECLQCGQDFEDST 386

  Fly   382 VFNLGEEISQEQQVFSFHENVIIVEKEQNDRDEQTPLKRKRSSELVFKQESS--CPQ-------- 436
            ........|...:||.      .|:...:.|..:|..|..|    :.|::::  ||:
Zfish   387 QLAAHRISSCNTRVFK------CVKCRAHFRSLRTLYKHNR----MHKEKTTHKCPECGRTFTSL 441

  Fly   437 -----PKTGRITDTVK-------------SF-------------------------QCHLCPVAF 458
                 .:.|..|.|:|             |:                         :|..|.:.|
Zfish   442 SQLVSHRRGHRTPTIKRNYTCKQCNETFGSYRASLIHQKIHKADAARPSKSDRQPGKCRFCDLTF 506

  Fly   459 PTQKLLTRHHNTHIKGLKSGKGGTLKCPSCALQLSCASSLKRHMIIHTGLKPFKCSECELSFSQR 523
            .....|..|..||      .:.....|..|....|..|||..|:..|||.||..||:|...|..:
Zfish   507 NIDSELRSHLKTH------AEFRPYICDQCGKCFSANSSLLAHLSNHTGEKPLLCSQCGKRFYSK 565

  Fly   524 EVLKRHMDTHTGVKRHQCPQCSSCFAQKSNLQQHIGRVHMGNSRTHKCHLCHRSFNHVSGLSRHL 588
            ..||.||..|:|.:.|.||.|...|:...||:.|| |:|.| .:.:.||.|.:.|.....|..||
Zfish   566 IQLKSHMRCHSGERPHICPYCEKQFSLSGNLKIHI-RIHTG-EKPYVCHQCGKGFVSAGCLQVHL 628

  Fly   589 VTHAGVM-FSCKQCGRQFNDRSAVQRHVT 616
            .:|.|.. :.||.||::|    .|..|:|
Zfish   629 RSHTGEKPYQCKICGKKF----VVSSHLT 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871
		vATP-synt_E	109..>244	CDD:304907	32/144 (22%)
		RRF	<161..222	CDD:294170	19/97 (20%)
		zf-C2H2_8	454..530	CDD:292531	24/75 (32%)
		C2H2 Zn finger	485..505	CDD:275368	7/19 (37%)
		zf-H2C2_2	497..522	CDD:290200	12/24 (50%)
		C2H2 Zn finger	513..533	CDD:275368	8/19 (42%)
		zf-H2C2_2	526..550	CDD:290200	11/23 (48%)
		C2H2 Zn finger	541..562	CDD:275368	9/20 (45%)
		C2H2 Zn finger	571..591	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..617	CDD:275368	8/19 (42%)
zgc:171422	NP_001107944.2	TIN2_N	18..189	CDD:240667	25/115 (22%)
		C2H2 Zn finger	347..367	CDD:275368	5/19 (26%)
		zf-C2H2_8	350..419	CDD:292531	15/74 (20%)
		C2H2 Zn finger	375..392	CDD:275368	2/16 (13%)
		C2H2 Zn finger	403..423	CDD:275368	5/23 (22%)
		zf-C2H2_8	406..478	CDD:292531	12/75 (16%)
		C2H2 Zn finger	431..451	CDD:275368	2/19 (11%)
		C2H2 Zn finger	462..482	CDD:275368	1/19 (5%)
		C2H2 Zn finger	499..519	CDD:275368	5/19 (26%)
		COG5048	<524..683	CDD:227381	51/136 (38%)
		C2H2 Zn finger	527..547	CDD:275368	7/19 (37%)
		C2H2 Zn finger	555..575	CDD:275368	8/19 (42%)
		zf-H2C2_2	568..591	CDD:290200	10/22 (45%)
		C2H2 Zn finger	583..603	CDD:275368	9/20 (45%)
		zf-H2C2_2	595..620	CDD:290200	11/26 (42%)
		C2H2 Zn finger	611..631	CDD:275368	7/19 (37%)
		zf-H2C2_2	624..647	CDD:290200	10/26 (38%)
		zf-C2H2	637..659	CDD:278523	8/21 (38%)
		C2H2 Zn finger	639..659	CDD:275368	8/19 (42%)
		C2H2 Zn finger	667..687	CDD:275368
		zf-H2C2_2	679..704	CDD:290200
		C2H2 Zn finger	695..715	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100