DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenB1A and ACAP1

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_055531.1	Gene:	ACAP1 / 9744	HGNCID:	16467	Length:	740	Species:	Homo sapiens

Alignment Length:	870	Identity:	282/870 - (32%)
Similarity:	417/870 - (47%)	Gaps:	183/870 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRATIEFEECLKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWD 65
            |...::||||||||||||..:...|:::..||.||||::||....::||:.|:....||.:.:.|
Human     1 MTVKLDFEECLKDSPRFRASIELVEAEVSELETRLEKLLKLGTGLLESGRHYLAASRAFVVGICD 65

  Fly    66 LQQHFLDNKNAHNALG----KLIHCFQEMNKF----------HTILLDQASRTVLKNLSVFVKDD 116
            |.:           ||    .:..|   :.||          |..|||....|:.:.:...||:.
Human    66 LAR-----------LGPPEPMMAEC---LEKFTVSLNHKLDSHAELLDATQHTLQQQIQTLVKEG 116

  Fly   117 INQVKDYKGHFLKVSEGYDNALIKNAQASKNRPQEMQEAANILSASKSCFQHTALDYVNYITLAQ 181
            :...::.:..|.:.:|..:.||..||:..:.|.||.:||...|..:::.::..||||...|.:.:
Human   117 LRGFREARRDFWRGAESLEAALTHNAEVPRRRAQEAEEAGAALRTARAGYRGRALDYALQINVIE 181

  Fly   182 ARKVPSILSTLLDYYQACVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQQLEKAMQNRHMSV- 245
            .::...|:..:|...:|..|::.||.:..:...::.|.:...|:.|..:..:.::.|:.||:.:
Human   182 DKRKFDIMEFVLRLVEAQATHFQQGHEELSRLSQYRKELGAQLHQLVLNSAREKRDMEQRHVLLK 246

  Fly   246 NRYCDSNTNSTSNK-------IEGYLFKKKSKGFKTWCRRWFYLSDNQLVYRKRSNEDSFSVMEE 303
            .:.........|.:       :||:|||:.|..||||.||||.:..|||||:|: .:|..:|:.:
Human   247 QKELGGEEPEPSLREGPGGLVMEGHLFKRASNAFKTWSRRWFTIQSNQLVYQKK-YKDPVTVVVD 310

  Fly   304 DLRICSVRPVNEGDRRFCFEVISPTKSHILQADSADMLSLWISALQHSIGAAIQHDSTHHSRPQS 368
            |||:|:|:...:.:|||||||:|.:||.:|||||..:|.||:||:|.||.:|.       |:.:.
Human   311 DLRLCTVKLCPDSERRFCFEVVSTSKSCLLQADSERLLQLWVSAVQSSIASAF-------SQARL 368

  Fly   369 TNAPNNSLPAKRRIHW--------------------------EEFLKIPGNAYCCDCRSPEPRWA 407
            .::|..  |.:...|.                          .:...:.|||.|||||.|.|.||
Human   369 DDSPRG--PGQGSGHLAIGSAATLGSGGMARGREPGGVGHVVAQVQSVDGNAQCCDCREPAPEWA 431

  Fly   408 SINLGITLCIECSGVHRSLGVHYSKVRSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLK 472
            |||||:||||:|||:|||||||:|||||||||:||.|.||:|.||||.::|:|||||: :...:|
Human   432 SINLGVTLCIQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCELGNVIINQIYEARV-EAMAVK 495

  Fly   473 KPTEQCEIGVREAWIKAKYVERRFVCGMPKPQELLASETAEVLSIDSGGVVEDGESGGSGIAKRA 537
            ||...|....:||||.|||||::|:..:|:.:                     |..||.|
Human   496 KPGPSCSRQEKEAWIHAKYVEKKFLTKLPEIR---------------------GRRGGRG----- 534

  Fly   538 TLSLGGTRKWAVKKLRRRQKQRSIPKTLSDDPSIYNTAKTGDELEDDDDDESINIPSMSLSISRD 602
                            |.:.|..:|...|..|
Human   535 ----------------RPRGQPPVPPKPSIRP--------------------------------- 550

  Fly   603 DLLVIGDDLALDRLETPGILGSDQESTDGESDAESPEELPFSQLDANQLLYMASVVH--NLPVMC 665
                           .||.|         .|..|.|.| ....|....||:.|| .|  :||.|.
Human   551 ---------------RPGSL---------RSKPEPPSE-DLGSLHPGALLFRAS-GHPPSLPTMA 589

  Fly   666 MAFALGADKMWKNPQDRQRSFLHQAVISGSVMACEFLLLNGAAIDAVDEMGYSALHISTAKGHIA 730
            .|.|.|||..|.|......:.|.||..:.|::||||||.|||.::..|..|...||.:|..||..
Human   590 DALAHGADVNWVNGGQDNATPLIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILGHTG 654

  Fly   731 QVYLLLKHKAAYDLSSSDGKKALDIAVDQENADIVTLLRLTQLNDEIGPNDEYNGE--DETYKNV 793
            ...|.||..|......|:|:..|.||::..||||||||||.::.:.    :...|:  ||||.::
Human   655 LACLFLKRGADLGARDSEGRDPLTIAMETANADIVTLLRLAKMREA----EAAQGQAGDETYLDI 715

  Fly   794 MKDFSKLPASQTRVL-RQRHDSNTL 817
            .:|||.:.:.....| |:.||.:||
Human   716 FRDFSLMASDDPEKLSRRSHDLHTL 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	52/212 (25%)
		PH	259..352	CDD:278594	48/99 (48%)
		PH_ACAP	260..355	CDD:270070	50/94 (53%)
		ArfGap	384..497	CDD:279720	69/138 (50%)
		ANK	652..768	CDD:238125	49/117 (42%)
		Ank_4	683..736	CDD:290365	21/52 (40%)
		ANK repeat	687..713	CDD:293786	13/25 (52%)
		ANK repeat	715..746	CDD:293786	10/30 (33%)
ACAP1	NP_055531.1	Required for formation of endosomal tubules when overexpressed with PIP5K1C	1..382		125/404 (31%)
		BAR	18..217	CDD:299863	52/212 (25%)
		PH	266..360	CDD:278594	49/94 (52%)
		PH_ACAP	268..364	CDD:270070	51/103 (50%)
		Required for interaction with GULP1	405..740		154/440 (35%)
		ArfGap	406..519	CDD:279720	69/113 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..581		21/156 (13%)
		Prevents interaction with ITGB1 when S-554 is not phosphorylated	525..566		16/140 (11%)
		ANK	<592..692	CDD:238125	41/99 (41%)
		ANK repeat	606..637	CDD:293786	13/30 (43%)
		Ank_5	626..680	CDD:290568	19/53 (36%)
		ANK repeat	639..670	CDD:293786	10/30 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	157	1.000	Domainoid score	I4143
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	541	1.000	Inparanoid score	I1188
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55583
OrthoDB	1	1.010	-	-		D124295at33208
OrthoFinder	1	1.000	-	-		FOG0000653
OrthoInspector	1	1.000	-	-		otm40931
orthoMCL	1	0.900	-	-		OOG6_101039
Panther	1	1.100	-	-	O	PTHR23180
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R258
SonicParanoid	1	1.000	-	-		X412
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870