DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenB1A and ASAP2

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_011508705.1	Gene:	ASAP2 / 8853	HGNCID:	2721	Length:	1020	Species:	Homo sapiens

Alignment Length:	902	Identity:	188/902 - (20%)
Similarity:	326/902 - (36%)	Gaps:	275/902 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EECLKDSPRFRQFVSKEESDIEHLE-QRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWDLQQHFL 71
            ||..:.:.|.|    .:..|::.:. .:::|.:|..|   .||..:|:|:..:..:|.....:.:
Human    41 EEVRRPARRLR----PQALDVDRMVLYKMKKSVKAIN---SSGLAHVENEEQYTQALEKFGGNCV 98

  Fly    72 --DNKNAHNALGKLIHCFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVK-DYKGHFLKVSEG 133
              |:.:..:|..|.....:|:......|:...:..:...|...:|.|:..|| |.|..|.|..:.
Human    99 CRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAWKD 163

  Fly   134 YDNALIKNAQASKNRPQ-------EMQ--EAANILSASKSCFQHTALDYVNYITLAQARKVPSIL 189
            |:..:.|..:..|...:       |:.  |.|..:...:..||....:|:..:...:.:|...:|
Human   164 YETKITKIEKEKKEHAKLHGMIRTEISGAEIAEEMEKERRFFQLQMCEYLLKVNEIKIKKGVDLL 228

  Fly   190 STLLDYYQACVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQQ-----------LEKAMQNRHM 243
            ..|:.|:.|...::..|...........:.:|.||:.::....:           |:.|:|....
Human   229 QNLIKYFHAQCNFFQDGLKAVESLKPSIETLSTDLHTIKQAQDEERRQLIQLRDILKSALQVEQK 293

  Fly   244 SVNRYCDSNTNSTS---------NK-----IEGYLFKKKSKGFKTWCRRWFYLSDNQLVYRKRSN 294
            ...|  ||....::         ||     ..|.|:||.....|.|.:            ||.|.
Human   294 ESRR--DSQIRQSTAYSLHQPQGNKEHGTERNGSLYKKSDGIRKVWQK------------RKCSV 344

  Fly   295 EDSFSVMEE----------DLRICSVRPVNEGDRRFCFEVISPTKSHILQADSADMLSLWISALQ 349
            ::.|..:..          :|..|.|: .|..::: ||::||..:::..||:......:|:|.||
Human   345 KNGFLTISHGTANRPPAKLNLLTCQVK-TNPEEKK-CFDLISHDRTYHFQAEDEQECQIWMSVLQ 407

  Fly   350 HSIGAAIQH-----DSTHHSRPQSTNAPNNSLPAKRRIHWEEFLKIPGNAYCCDCRSPEPRWASI 409
            :|...|:.:     |:|         ..||.:....:....|..::.||..||||.:|:|.|.|.
Human   408 NSKEEALNNAFKGDDNT---------GENNIVQELTKEIISEVQRMTGNDVCCDCGAPDPTWLST 463

  Fly   410 NLGITLCIECSGVHRSLGVHYSKVRSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKP 474
            ||||..||||||:||.||||||:::|||||...:..:.:...:||...|.|.|..:..:..: ||
Human   464 NLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNIGNAGFNEIMECCLPAEDSV-KP 527

  Fly   475 TEQCEIGVREAWIKAKYVERRFVCGMPKPQELLASETAEVLSIDSGGVVEDGESGGSGIAKRATL 539
            ....::..|:.:|.|||:|||:.
Human   528 NPGSDMNARKDYITAKYIERRYA------------------------------------------ 550

  Fly   540 SLGGTRKWAVKKLRRRQKQRSIPKTLSDDPSIYNTAKTGDELEDDDDDESINIPSMSLSISRDDL 604
                           |:|..                           |.:..:.|:
Human   551 ---------------RKKHA---------------------------DNAAKLHSL--------- 564

  Fly   605 LVIGDDLALDRLETPGILGSDQESTDGESDAESPEELPFSQLDANQLLYMASVVHNLPVMCMAFA 669
                    .:.::|..|.|..|...||   .:..|::|.:
Human   565 --------CEAVKTRDIFGLLQAYADG---VDLTEKIPLA------------------------- 593

  Fly   670 LGADKMWKNPQDRQRSFLHQAVIS---GSVMACEFLLLNGAAIDAVDEMGYSALHISTAKGHIAQ 731
                    |..:...:.||.||.|   .|:...:||:.|...:|.....|.:|||......:...
Human   594 --------NGHEPDETALHLAVRSVDRTSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAEC 650

  Fly   732 VYLLLKHKAAYDLSSSDGKKALDIA--VDQENADIVTLLRLTQ------------------LNDE 776
            :.|||:.||:.::::..|:..||||  :..|:.:.:    |||                  |:::
Human   651 LKLLLRGKASIEIANESGETPLDIAKRLKHEHCEEL----LTQALSGRFNSHVHVEYEWRLLHED 711

  Fly   777 IGPNDEYNGEDETYKNVMKDFSKLPASQTRVLRQRHD---------SNTLESQRSSL 824
            :..:|:...|            ||..|..|    |.|         ||.|:|...||
Human   712 LDESDDDMDE------------KLQPSPNR----REDRPISFYQLGSNQLQSNAVSL 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	39/211 (18%)
		PH	259..352	CDD:278594	25/107 (23%)
		PH_ACAP	260..355	CDD:270070	25/104 (24%)
		ArfGap	384..497	CDD:279720	49/112 (44%)
		ANK	652..768	CDD:238125	26/120 (22%)
		Ank_4	683..736	CDD:290365	15/55 (27%)
		ANK repeat	687..713	CDD:293786	10/28 (36%)
		ANK repeat	715..746	CDD:293786	9/30 (30%)
ASAP2	XP_011508705.1	BAR	34..259	CDD:299863	42/224 (19%)
		PH_ASAP	311..417	CDD:270071	28/119 (24%)
		PH	320..407	CDD:278594	22/100 (22%)
		ArfGap	435..552	CDD:279720	49/174 (28%)
		ANK repeat	564..596	CDD:293786	9/84 (11%)
		ANK	<593..687	CDD:238125	26/130 (20%)
		ANK repeat	600..632	CDD:293786	10/31 (32%)
		Ank_5	621..675	CDD:290568	15/53 (28%)
		ANK repeat	634..665	CDD:293786	9/30 (30%)
		SH3_ASAP2	962..1017	CDD:212899
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820