DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenB1A and SPS18

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_014195.1	Gene:	SPS18 / 855517	SGDID:	S000005148	Length:	300	Species:	Saccharomyces cerevisiae

Alignment Length:	333	Identity:	72/333 - (21%)
Similarity:	122/333 - (36%)	Gaps:	116/333 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   389 KIPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLDAWESENVKVMMELG 453
            |..||..|.:|:|..|::.|.:.||.:|:.|:.:.|.:|.:...|:|:|:|.:|.::|:.:.:.|
Yeast    21 KAAGNNNCFECKSVNPQFVSCSFGIFICVNCANLLRGMGTNIFCVKSITMDNFEEKDVRRVEKSG 85

  Fly   454 NEVVNRIYEARIGDDCGLKKPTEQCEIGVREAW--IKAKYVERRFVCGMPKPQELLASETAEVLS 516
            |.        |.|.... |....|..|.:||.:  :.||..:||           ||:   ||.|
Yeast    86 NN--------RFGSFLS-KNGILQNGIPLREKYDNLFAKSYKRR-----------LAN---EVRS 127

  Fly   517 IDSGGVVEDGESGGSGIAKRATLSLGGTRKW---AVKKLRRRQKQRSIPKTLSDDPSIYNTAKTG 578
            .|              |.:...|.....:::   |..::|.|        ||.:   |.|.:...
Yeast   128 ND--------------INRNMYLGFNNFQQYTNGATSQIRDR--------TLRE---ISNNSNAS 167

  Fly   579 DELEDDDDDESINIPSMSLSISRDDLLVIGDDLALDRLETPGILGSDQESTDGESDAESPEELPF 643
            :..|       ..:|..          |:|.|...|....|..|.|::
Yeast   168 EGAE-------FVLPEK----------VLGSDNFQDCERFPACLSSER----------------- 198

  Fly   644 SQLDANQLLYMASVV-----HNLPV--MCMAFALGADKMWKN---------------------PQ 680
             .||.|.:....|.:     .|.|:  :..::.|.:|.::|:                     |.
Yeast   199 -NLDENNVTSATSTLTIEKFQNDPIGTISRSWQLLSDALYKSYEDFKGSVVQPTIENIQQRNLPN 262

  Fly   681 DRQRSFLH 688
            |.:|||:|
Yeast   263 DIKRSFVH 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287
		PH	259..352	CDD:278594
		PH_ACAP	260..355	CDD:270070
		ArfGap	384..497	CDD:279720	33/109 (30%)
		ANK	652..768	CDD:238125	12/65 (18%)
		Ank_4	683..736	CDD:290365	4/6 (67%)
		ANK repeat	687..713	CDD:293786	1/2 (50%)
		ANK repeat	715..746	CDD:293786
SPS18	NP_014195.1	COG5347	6..300	CDD:227651	72/333 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900