DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenB1A and ARFGAP2

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_005253223.1	Gene:	ARFGAP2 / 84364	HGNCID:	13504	Length:	560	Species:	Homo sapiens

Alignment Length:	423	Identity:	96/423 - (22%)
Similarity:	149/423 - (35%)	Gaps:	132/423 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   377 PAKRRIH--WEEFLKIPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLD 439
            |.|..|.  ::....:|.|..|.||.:..|.||||..|:.|||:|||||||||||.|.:||..||
Human     5 PNKTEIQTLFKRLRAVPTNKACFDCGAKNPSWASITYGVFLCIDCSGVHRSLGVHLSFIRSTELD 69

  Fly   440 A-WESENVKVMMELGNEVVNRIYE---------------------------------ARIGDDCG 470
            : |....::.|...||......:.                                 ||.|.|..
Human    70 SNWNWFQLRCMQVGGNANATAFFRQHGCTANDANTKYNSRAAQMYREKIRQLGSAALARHGTDLW 134

  Fly   471 L-------------KKPTE------QCEIGV----REAWI-KAKYVERRFVCGMPKPQELLASET 511
            :             ||.::      |..:|:    ::.|: :|..:...|   .|...:..|:|.
Human   135 IDNMSSAVPNHSPEKKDSDFFTEHTQVLVGLGASCQQEWLTEASVIWPPF---QPPAWDAPATEP 196

  Fly   512 A----EVLSIDSGGVVEDGESGGS----GIAKRATLS-------------------LGGTRKWAV 549
            :    ...|.:|.|:.:. |.|.:    |.:.:|:|.                   :|..:..|.
Human   197 SGTQQPAPSTESSGLAQP-EHGPNTDLLGTSPKASLESVYLSAKGALPARELKSSIIGKKKPAAA 260

  Fly   550 KKLRRRQKQRSIPKTLSDDPS-IYNTAKTGDELEDD-------DDDESINIPSMSLSISRDDLLV 606
            ||....:|.....|..|...| |...|:..::|.:.       ..:||: :.||.|:.
Human   261 KKGLGAKKGLGAQKVSSQSFSEIERQAQVAEKLREQQAADAKKQAEESM-VASMRLAY------- 317

  Fly   607 IGDDLALDRLETPGILGSDQESTDGESDAESPEELPF-----SQLDANQLLYMASVVHNLPVMCM 666
              .:|.:||.:....|    ::.:|:. .|..|.|..     |.:..:.|..|..:....||...
Human   318 --QELQIDRKKEEKKL----QNLEGKK-REQAERLGMGLVSRSSVSHSVLSEMQVIEQETPVSAK 375

  Fly   667 A-------------FALGADKMWKNPQDRQRSF 686
            :             ||.|..|...||.....||
Human   376 SSRSQLDLFDDVGTFASGPPKYKDNPFSLGESF 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287
		PH	259..352	CDD:278594
		PH_ACAP	260..355	CDD:270070
		ArfGap	384..497	CDD:279720	44/170 (26%)
		ANK	652..768	CDD:238125	11/48 (23%)
		Ank_4	683..736	CDD:290365	2/4 (50%)
		ANK repeat	687..713	CDD:293786	96/423 (23%)
		ANK repeat	715..746	CDD:293786
ARFGAP2	XP_005253223.1	PLN03114	1..510	CDD:178661	96/423 (23%)
		ArfGap	11..117	CDD:279720	34/105 (32%)
		RILP-like	266..>338	CDD:304877	17/85 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900