DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenB1A and AGD4

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001320312.1	Gene:	AGD4 / 837629	AraportID:	AT1G10870	Length:	780	Species:	Arabidopsis thaliana

Alignment Length:	843	Identity:	215/843 - (25%)
Similarity:	347/843 - (41%)	Gaps:	190/843 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWDLQQHF----- 70
            |:|||.|::.|...|...:.|:.|.:|:.|.....:.:..|..|.:||||..|    :.|
plant     7 LEDSPMFQKQVCSLEGTADELKDRCQKLYKGVKKFMGTLGEASKGESAFAACL----EEFGGGPD 67

  Fly    71 --LDNKNAHNALGKLIHCFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVKDYKGHFLKVSEG 133
              :........:.|.|:..:|:..:...|..|....:|:.|..|:..|:.:.|:.:..|.|.:..
plant    68 DPISLSIGGPVISKFINALRELASYKEFLCSQVEHVLLERLMNFISVDLQEAKESRHRFDKAAHS 132

  Fly   134 YDNALIKNAQASKN-RPQEMQEAANILSASKSCFQHTALDYVNYITLAQARKVPSILSTLLDYYQ 197
            ||.:..|.....|| |.:.:.|....|..|||.|:.:..:.||.:...:|:|....|.::.....
plant   133 YDQSREKFVSLKKNTRGEIVAELEEDLENSKSTFEKSRFNLVNSLMTIEAKKKYEFLESISAIMD 197

  Fly   198 ACVTYYHQGFDLCNDFDEFF-------------KNISEDLNALR---------GDYQQLEKAMQN 240
            |.:.|:..|:||.|..:.|.             ..|.:|..|.|         .|.|||....::
plant   198 AHLRYFKLGYDLLNQLEPFIHQILTYAQQSKEQSKIEQDRLARRIQEFRTQSELDSQQLVANAES 262

  Fly   241 RHMSVNR------YCDSNTNSTSNK---IEGYLFKKKSKGFKTWCRRWFYLSDNQLVYRKRSN-- 294
            ...:.||      |.::.|:.|::|   .:|||.|:.|.....|.|::|.|..:..:|..|:|
plant   263 SGANGNRVGGNIPYKNTETSLTADKEVIKQGYLLKRSSSLRTDWKRKFFVLDSHGSMYYYRTNGN 327

  Fly   295 ----------------------------------EDSFSVMEEDLRICSVR-PVNEGDRRFCFEV 324
                                              |.|......|||...:: ...:.|.|.||.:
plant   328 KSMGSHHHYSGSSDHNTGVFGRFRARHNRSGSLTEGSLGYNTIDLRTSLIKLDAEDMDLRLCFRI 392

  Fly   325 ISPTKSHILQADS-ADMLSLWISALQHSIGAAI------QHDSTHHSRPQSTNAPNNSLPAKRRI 382
            |||.|::.|||:: ||.:. |::.:..:||..:      |....:..:..|::||.|::.:..:|
plant   393 ISPQKTYTLQAENGADRMD-WVNKITKAIGTLLNSHFLQQSPVRYLDKDNSSSAPANAVVSGDQI 456

  Fly   383 HWEEFLK------------IPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKVRS 435
            ...:..:            :|||..|.:|.:|||.|||:|||:.|||:||||||:||||.|||||
plant   457 RHNDSRQNIGDDVSTILRGLPGNNACAECNAPEPDWASLNLGVLLCIQCSGVHRNLGVHISKVRS 521

  Fly   436 LTLD--AWESENVKVMMELGNEVVNRIYEA--RIGDDC--------------GLKKPTEQCEIGV 482
            |:||  .||...:.:...|||...|.::|.  .:.|||              .:.||..:....|
plant   522 LSLDVKVWEPTILDLFRNLGNVYCNSLWEGLLHLDDDCVAFCSEDGSALSHASVSKPCPEDSFSV 586

  Fly   483 REAWIKAKYVERRFVCGMPKPQELLASETAEVLSIDSGGVVEDGESGGSGIAKRATLSLGGTRKW 547
            :|.:|..||:|:..|                        :.::.|         |.|| ..:|.|
plant   587 KEKYILGKYLEKALV------------------------IKDESE---------ANLS-AASRIW 617

  Fly   548 -AVKKLRRRQKQRSIPKTLSDDPSIYNTAKTGDELEDDDDDESINIPSMSLSISRDDLLVIGDDL 611
             ||:....|:..|.|..|  .|.:|.||  ..|::.|.|....|:                ..:.
plant   618 EAVQSRNIREIYRLIVTT--GDVNIINT--KFDDITDIDAYHHID----------------AAEK 662

  Fly   612 ALDRLETPGILGSDQESTDGESDAESPEELPFSQLDANQLLYMASVVHNLPVMCMAFALGADKMW 676
            |:.:...|.:....:||.:           |.|.|....||::|..:.:..::.:....|||
plant   663 AVKKRHDPTVCQRIKESNE-----------PRSCLQGCSLLHVACHIGDSVLLELLLQFGAD--- 713

  Fly   677 KNPQD-RQRSFLHQAVISGSVMACEFLLLNGAAIDAVDEMGYSALHISTAKGHIA--QVYLLL 736
            .|.:| ..|:.||..:.||:....:.||..||.....|:.|.|.|..:...|.|.  :::|||
plant   714 LNIRDYHGRTPLHHCISSGNHKFAKILLRRGARPSIEDDGGLSVLERAMEMGAITDEELFLLL 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	49/206 (24%)
		PH	259..352	CDD:278594	32/133 (24%)
		PH_ACAP	260..355	CDD:270070	33/132 (25%)
		ArfGap	384..497	CDD:279720	53/142 (37%)
		ANK	652..768	CDD:238125	25/88 (28%)
		Ank_4	683..736	CDD:290365	16/54 (30%)
		ANK repeat	687..713	CDD:293786	8/25 (32%)
		ANK repeat	715..746	CDD:293786	8/24 (33%)
AGD4	NP_001320312.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	78	1.000	Domainoid score	I3054
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H8182
Inparanoid	1	1.050	213	1.000	Inparanoid score	I1240
OMA	1	1.010	-	-		QHG55583
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	1	1.000	-	-		FOG0000653
OrthoInspector	1	1.000	-	-		otm2433
orthoMCL	1	0.900	-	-		OOG6_101039
Panther	1	1.100	-	-	O	PTHR23180
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X412
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840