Protein Alignment CenB1A and Git1

DIOPT Version :10

• Sequence 1: NP_524458.1
• Gene: CenB1A / 42735
• FlyBaseID: FBgn0039056
• Length: 828
• Species: Drosophila melanogaster
• Sequence 2: NP_114002.1
• Gene: Git1 / 83709
• RGDID: 69331
• Length: 770
• Species: Rattus norvegicus
• Alignment Length: 118
• Identity: 42/118 - (35%)
• Similarity: 63/118 - (53%)
• Gaps: 5/118 - (4%)

  Fly   389 KIPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLDAWESENVKVMMELG 453
            |.|....|.||.:|:|.||||:.|:.:|.||..||||||.|.|.|:.|...||....::::..|.
  Rat     4 KGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLA 68

  Fly   454 NEVVNRIYEARIGD----DCGLKKPTEQCEI-GVREAWIKAKYVERRFVCGMP 501
            :...|.|:|..:.|    ..|.:|...|.:: .::..:|:|||....||..:|
  Rat    69 SNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLP 121

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287
		PH_ACAP	260..355	CDD:270070
		ArfGap_ACAP	381..497	CDD:350064	39/112 (35%)
		ANKYR	<647..>768	CDD:440430
		ANK repeat	687..713	CDD:293786
		ANK repeat	715..746	CDD:293786
Git1	NP_114002.1	Interaction with gamma-tubulin and localization to the centrosome. /evidence=ECO:0000250|UniProtKB:Q9Y2X7	1..124		42/118 (36%)
		ArfGap_GIT1	1..111	CDD:350071	37/106 (35%)
		ANKYR	<123..221	CDD:440430
		ANK 1	132..161
		ANK repeat	137..165	CDD:293786
		ANK 2	166..195
		ANK repeat	167..197	CDD:293786
		ANK 3	199..228
		Interaction with PCLO. /evidence=ECO:0000269|PubMed:12473661	245..374
		Interaction with PTK2/FAK1. /evidence=ECO:0000269|PubMed:10938112	253..424
		Interaction with ARHGEF7. /evidence=ECO:0000269|PubMed:10938112	254..376
		GIT_SHD	<281..301	CDD:462506
		GIT_SHD	337..365	CDD:462506
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	363..425
		Interaction with NCK2 and GRIN3A. /evidence=ECO:0000269|PubMed:17310244, ECO:0000269|PubMed:24297929	375..596
		Required for localization at synapses. /evidence=ECO:0000250|UniProtKB:Q9Y2X7	375..596
		GIT_CC	418..483	CDD:465174
		Interaction with MAPK1. /evidence=ECO:0000250|UniProtKB:Q68FF6	420..475
		Interaction with IKBKG. /evidence=ECO:0000250|UniProtKB:Q9Y2X7	429..629
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	574..615
		Interaction with PXN and TGFB1I1. /evidence=ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:12153727	646..770
		GIT1_C	652..765	CDD:463492