DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenB1A and AGD1

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_201004.2	Gene:	AGD1 / 836319	AraportID:	AT5G61980	Length:	828	Species:	Arabidopsis thaliana

Alignment Length:	931	Identity:	213/931 - (22%)
Similarity:	333/931 - (35%)	Gaps:	286/931 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWDLQQHFLDNKN 75
            |.|||.|||.:...|...|.|..|..:..|.|....:...|.......|..:|    :.|   ..
plant     6 LDDSPMFRQQMQSMEESAELLRLRCLRFYKGCRKYTEGLGEGYDADIGFVNAL----ESF---GG 63

  Fly    76 AHN-----ALG-----KLIHCFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVKDYKGHFLKV 130
            .||     |.|     |.....:|:..:..:|..|....:...|..||..|:::||:.:..|.|.
plant    64 GHNDPVCVAFGGPVMTKFTIALREIGTYKEVLRSQVEHMLSDRLLQFVNGDVHEVKEARKRFDKA 128

  Fly   131 SEGYDNALIKNAQASKNRPQEMQEAANI---LSASKSCFQHTALDYVNYITLAQARKVPSILSTL 192
            :..||.|  :....|..:...:..||.|   |.::::.|:......|:.::.|:::|....|..:
plant   129 TITYDQA--REKYLSLRKSTRLDVAATIEEDLHSARTTFEQARFHLVSALSNAESKKRFEFLEAV 191

  Fly   193 LDYYQACVTYYHQGFDLCNDFDEFFKNI--------------SEDLNALRGDYQ-QLEKAMQN-- 240
            .....|.:.::.||::|.:..:.|...:              ...||....:|| |:::..:|
plant   192 SGTMDAHLRFFKQGYELLHQMEPFINQVLAYAHQSRECANYEMASLNERMQEYQRQVDRETRNSC 256

  Fly   241 --------RHMSVN--RYCDSNTNSTS-NKI----EGYLFKKKSKGFKTWCRRWFYLSDNQLVYR 290
                    ||.|.|  :..::...|.: .|:    :|||.|:.|.....|.||:|.|....::|.
plant   257 VSPTGDGMRHNSRNSQKVIEAVMQSAAKGKVQTIRQGYLSKRSSNLRGDWKRRFFILDSRGMLYY 321

  Fly   291 KR------SNEDSFSVMEEDLR-------------------ICSVRPV----------------N 314
            .|      |...|.||:..::.                   :...:||                :
plant   322 YRKPWNWSSGNGSRSVVHRNMASENSPGLLSRWLSSHYHGGVHDEKPVARHTVNLLTSTIKVDAD 386

  Fly   315 EGDRRFCFEVISPTKSHILQADSADMLSLWISALQHSIG-------------------------- 353
            :.|.||||.:|||||.:.|||::|.....||..:...|.
plant   387 QTDLRFCFRIISPTKVYTLQAENAQDQMDWIEKITGVIASLLSFQTPERAIMRLSTVDGGDTFSA 451

  Fly   354 -------------------AAIQHDSTHHSRPQSTNAPNNSLPAKRRIHWEEFLKIPGNAYCCDC 399
                               :.::|..|..:|.:.:.........|.....:...::.||..|.||
plant   452 SDSGSLADPYDIEQAESGESTVEHPMTGGNRSRFSGCLQQHDMVKTEKPIDVLTRVLGNERCADC 516

  Fly   400 RSPEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLD--AWESENVKVMMELGNEVVNRIYE 462
            .:|||.|||:|||:.:||||||:||:||||.|||||||||  .||...:.:...|||..||.::|
plant   517 GAPEPDWASLNLGVLICIECSGIHRNLGVHISKVRSLTLDVKVWEPSVLTLFQSLGNVYVNSVWE 581

  Fly   463 ARIGDDCG--------------------LKKPTEQCEIGVREAWIKAKYVERRFVCGMPKPQELL 507
            ..:..:..                    ::||.....|.|:|.:|.|||.||.||......|...
plant   582 ELLNSESRTSSASRSSGTPKSDRPRKLLVRKPGFNDPISVKELFIHAKYSERIFVRKAIDSQHFQ 646

  Fly   508 A--SETAE-VLSIDSGGV---VEDGESGGSGIAKRA--TLSLGGTRKWAVKKLRRRQ-----KQR 559
            |  .|..| |.:.|...|   :...|:..:.:..:|  |:||      .:.|:.:.:     |.:
plant   647 AVFQEIWENVRANDKKSVYRHIVCSEADVNALRGQASYTVSL------PLSKMMQMEETLEAKFK 705

  Fly   560 SIPKTLSDDPSIYNTAKTGDELEDDDDDESINIPSMSLSISRDDLLVIGDDLALDRLETPGILGS 624
            ||.:...::|:.|:.::                               ||..::.|.||
plant   706 SIEEEFQENPAGYSNSR-------------------------------GDGESMVREET------ 733

  Fly   625 DQESTDGESDAESPEELPFSQLDANQLLYMASVVHNLPVMCMAFALGADKMWKNPQDRQRSFLHQ 689
               |.|                                  |                   |.||.
plant   734 ---SND----------------------------------C-------------------SLLHL 742

  Fly   690 AVISGSVMACEFLLLNGAAIDAVDEMGYSALHISTAKGHIAQVYLLLKHKAAYDLSSSDGKKALD 754
            |.:|..:...|.||..||.|:|.|..|.:.||........|...|||       :...|..
plant   743 ACLSADIGMVELLLQYGAKINATDSKGRTPLHHCIISRRYAIARLLL-------MRGGDPN---- 796

  Fly   755 IAVDQENADIVTLLRLTQLND 775
             |||:::...|.....|.|||
plant   797 -AVDKDSNIPVKYASQTDLND 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	45/211 (21%)
		PH	259..352	CDD:278594	35/137 (26%)
		PH_ACAP	260..355	CDD:270070	35/184 (19%)
		ArfGap	384..497	CDD:279720	54/134 (40%)
		ANK	652..768	CDD:238125	26/115 (23%)
		Ank_4	683..736	CDD:290365	18/52 (35%)
		ANK repeat	687..713	CDD:293786	11/25 (44%)
		ANK repeat	715..746	CDD:293786	7/30 (23%)
AGD1	NP_201004.2	BAR_SFC_plant	15..215	CDD:153290	43/208 (21%)
		PH	289..425	CDD:278594	34/135 (25%)
		PH_ACAP	291..429	CDD:270070	35/137 (26%)
		ArfGap	498..639	CDD:279720	56/140 (40%)
		ANK	734..>826	CDD:238125	32/148 (22%)
		Ank_4	738..789	CDD:290365	18/50 (36%)
		ANK repeat	740..766	CDD:293786	11/25 (44%)
		ANK repeat	768..799	CDD:293786	9/42 (21%)
		Ank_4	769..823	CDD:290365	16/60 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	78	1.000	Domainoid score	I3054
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	213	1.000	Inparanoid score	I1240
OMA	1	1.010	-	-		QHG55583
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	1	1.000	-	-		FOG0000653
OrthoInspector	1	1.000	-	-		otm2433
orthoMCL	1	0.900	-	-		OOG6_101039
Panther	1	1.100	-	-	O	PTHR23180
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X412
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.840