Protein Alignment CenB1A and Acap2

DIOPT Version :10

• Sequence 1: NP_524458.1
• Gene: CenB1A / 42735
• FlyBaseID: FBgn0039056
• Length: 828
• Species: Drosophila melanogaster
• Sequence 2: XP_006522806.1
• Gene: Acap2 / 78618
• MGIID: 1925868
• Length: 816
• Species: Mus musculus
• Alignment Length: 862
• Identity: 336/862 - (38%)
• Similarity: 484/862 - (56%)
• Gaps: 97/862 - (11%)

  Fly     1 MRATIEFEECLKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWD 65
            |:.|::||||||||||||..:.:.|.|:..||.:|:|::|||...:|:||.:......|...:.|
Mouse     1 MKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRD 65

  Fly    66 LQQHFLDNKNAHNALGKLIHCFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVKDYKGHFLKV 130
            |.|:..::.....:|.|.....|||..|||||.||..|::...|..|||:|:.:.||.|..|.||
Mouse    66 LAQYSSNDAVVETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKFKDAKKQFEKV 130

  Fly   131 SEGYDNALIKNAQASKNRPQEMQEAANILSASKSCFQHTALDYVNYITLAQARKVPSILSTLLDY 195
            ||..:|||:||||..:|:..|::||||||:|::.||:|.|||||..|.:.|:::...||.::|.:
Mouse   131 SEEKENALVKNAQVQRNKQHEVEEAANILTATRKCFRHIALDYVLQINVLQSKRRSEILKSMLSF 195

  Fly   196 YQACVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQQLEKAMQNRHMSVNRYC--------DS- 251
            ..|.:.::|||:||.::...:.|::...|:.|..|..:.::.|:.:|.::.:..        ||
Mouse   196 MYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKREMEQKHSTIQQKAALQDFSSDDSK 260

  Fly   252 ---NTNSTSNKI-EGYLFKKKSKGFKTW-------CRRWFYLSDNQLVYRKRSNEDSFSVMEEDL 305
               |.::.:..: ||||||:.|..||||       .||||.:.:|||||:|:. :||.:|:.|||
Mouse   261 LEYNVDAANGIVMEGYLFKRASNAFKTWNRKKPDHIRRWFSIQNNQLVYQKKF-KDSPTVVVEDL 324

  Fly   306 RICSVRPVNEGDRRFCFEVISPTKSHILQADSADMLSLWISALQHSIGAAIQHDSTHHSRPQSTN 370
            |:|:|:...:.:|||||||:|||||.:|||||..:...||.|:|.||..|.:.......:....:
Mouse   325 RLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKS 389

  Fly   371 APNNSLPAKRRIHWEEFLK----------IPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRS 425
            :|:...........|:.||          ||||..||||...:||||||||||||||||||:|||
Mouse   390 SPSTGSLDSGNESKEKLLKGESALQRVQCIPGNTSCCDCGLADPRWASINLGITLCIECSGIHRS 454

  Fly   426 LGVHYSKVRSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEIGVR---EAWI 487
            ||||:|||||||||.||.|.:|:|.||||:|:||:|||:: :..|:|||    :.|.|   ||:|
Mouse   455 LGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYEAKL-EKMGVKKP----QPGQRQEKEAYI 514

  Fly   488 KAKYVERRFVCGMPKPQELLASETAEVLSIDSGGVVEDGESGGSGIAKRATLSLGGTRKWAVKKL 552
            :||||||:||   .|...||:....|...|...  .||.....:    ||::.   |...||...
Mouse   515 RAKYVERKFV---DKYSALLSPSEQEKRIISKS--CEDQRLSHA----RASVH---TPVAAVTSD 567

  Fly   553 RRRQKQRSIPKTLSDDPSIYNTA------KTGDE-LEDDDDDESINIPSMSLSISRDDLLVIGDD 610
            ..|::....|..|....|.::|:      |:.|. ::...:|...::||   ::|.:.|.
Mouse   568 EARRESLFCPDELDSLFSYFDTSSKLRSIKSNDSGIQQCSEDGRESLPS---TVSANSLY----- 624

  Fly   611 LALDRLETPGILGSDQESTDGESDAESPEELPFSQLDANQL-----LYMASVVHNLPVMCMAFAL 670
                                 |.:.|..|...|  ||:..|     ||.||...|||.|..|.|.
Mouse   625 ---------------------EPEGERQESSVF--LDSKHLNPGLQLYRASYEKNLPKMAEALAH 666

  Fly   671 GADKMWKNPQDRQRSFLHQAVISGSVMACEFLLLNGAAIDAVDEMGYSALHISTAKGHIAQVYLL 735
            |||..|.|..:.|.:.|.|||:.||::.|||||.|||.::..|..|...||.:|..||..||.|.
Mouse   667 GADVNWANSDENQATPLIQAVLGGSLVTCEFLLQNGANVNQRDVQGRGPLHHATVLGHTGQVCLF 731

  Fly   736 LKHKAAYDLSSSDGKKALDIAVDQENADIVTLLRLTQLNDEIGPNDEYNGE--DETYKNVMKDFS 798
            ||..|....:..:||..|.|||:..||||||||||.::|:|:..::...|:  ||||:::.:|||
Mouse   732 LKRGANQHATDEEGKDPLSIAVEAANADIVTLLRLARMNEEMRESEGLYGQPGDETYQDIFRDFS 796

  Fly   799 KLPASQTRVL-RQRHDS 814
            ::.::....| |.:.||
Mouse   797 QMASNNPEKLNRFQQDS 813

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	78/198 (39%)
		PH_ACAP	260..355	CDD:270070	53/102 (52%)
		ArfGap_ACAP	381..497	CDD:350064	75/128 (59%)
		ANKYR	<647..>768	CDD:440430	57/125 (46%)
		ANK repeat	687..713	CDD:293786	14/25 (56%)
		ANK repeat	715..746	CDD:293786	12/30 (40%)
Acap2	XP_006522806.1	BAR_ACAP2	18..217	CDD:153322	78/198 (39%)
		PH_ACAP	273..376	CDD:270070	54/103 (52%)
		COG5347	398..>635	CDD:227651	104/282 (37%)
		ArfGap_ACAP2	410..524	CDD:350076	72/118 (61%)
		ANKYR	<648..779	CDD:440430	61/130 (47%)
		ANK repeat	676..709	CDD:293786	15/32 (47%)
		ANK repeat	711..742	CDD:293786	12/30 (40%)