DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenB1A and Acap2

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_006522806.1	Gene:	Acap2 / 78618	MGIID:	1925868	Length:	816	Species:	Mus musculus

Alignment Length:	862	Identity:	336/862 - (38%)
Similarity:	484/862 - (56%)	Gaps:	97/862 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRATIEFEECLKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWD 65
            |:.|::||||||||||||..:.:.|.|:..||.:|:|::|||...:|:||.:......|...:.|
Mouse     1 MKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRD 65

  Fly    66 LQQHFLDNKNAHNALGKLIHCFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVKDYKGHFLKV 130
            |.|:..::.....:|.|.....|||..|||||.||..|::...|..|||:|:.:.||.|..|.||
Mouse    66 LAQYSSNDAVVETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKFKDAKKQFEKV 130

  Fly   131 SEGYDNALIKNAQASKNRPQEMQEAANILSASKSCFQHTALDYVNYITLAQARKVPSILSTLLDY 195
            ||..:|||:||||..:|:..|::||||||:|::.||:|.|||||..|.:.|:::...||.::|.:
Mouse   131 SEEKENALVKNAQVQRNKQHEVEEAANILTATRKCFRHIALDYVLQINVLQSKRRSEILKSMLSF 195

  Fly   196 YQACVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQQLEKAMQNRHMSVNRYC--------DS- 251
            ..|.:.::|||:||.::...:.|::...|:.|..|..:.::.|:.:|.::.:..        ||
Mouse   196 MYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKREMEQKHSTIQQKAALQDFSSDDSK 260

  Fly   252 ---NTNSTSNKI-EGYLFKKKSKGFKTW-------CRRWFYLSDNQLVYRKRSNEDSFSVMEEDL 305
               |.::.:..: ||||||:.|..||||       .||||.:.:|||||:|:. :||.:|:.|||
Mouse   261 LEYNVDAANGIVMEGYLFKRASNAFKTWNRKKPDHIRRWFSIQNNQLVYQKKF-KDSPTVVVEDL 324

  Fly   306 RICSVRPVNEGDRRFCFEVISPTKSHILQADSADMLSLWISALQHSIGAAIQHDSTHHSRPQSTN 370
            |:|:|:...:.:|||||||:|||||.:|||||..:...||.|:|.||..|.:.......:....:
Mouse   325 RLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKS 389

  Fly   371 APNNSLPAKRRIHWEEFLK----------IPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRS 425
            :|:...........|:.||          ||||..||||...:||||||||||||||||||:|||
Mouse   390 SPSTGSLDSGNESKEKLLKGESALQRVQCIPGNTSCCDCGLADPRWASINLGITLCIECSGIHRS 454

  Fly   426 LGVHYSKVRSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEIGVR---EAWI 487
            ||||:|||||||||.||.|.:|:|.||||:|:||:|||:: :..|:|||    :.|.|   ||:|
Mouse   455 LGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYEAKL-EKMGVKKP----QPGQRQEKEAYI 514

  Fly   488 KAKYVERRFVCGMPKPQELLASETAEVLSIDSGGVVEDGESGGSGIAKRATLSLGGTRKWAVKKL 552
            :||||||:||   .|...||:....|...|...  .||.....:    ||::.   |...||...
Mouse   515 RAKYVERKFV---DKYSALLSPSEQEKRIISKS--CEDQRLSHA----RASVH---TPVAAVTSD 567

  Fly   553 RRRQKQRSIPKTLSDDPSIYNTA------KTGDE-LEDDDDDESINIPSMSLSISRDDLLVIGDD 610
            ..|::....|..|....|.::|:      |:.|. ::...:|...::||   ::|.:.|.
Mouse   568 EARRESLFCPDELDSLFSYFDTSSKLRSIKSNDSGIQQCSEDGRESLPS---TVSANSLY----- 624

  Fly   611 LALDRLETPGILGSDQESTDGESDAESPEELPFSQLDANQL-----LYMASVVHNLPVMCMAFAL 670
                                 |.:.|..|...|  ||:..|     ||.||...|||.|..|.|.
Mouse   625 ---------------------EPEGERQESSVF--LDSKHLNPGLQLYRASYEKNLPKMAEALAH 666

  Fly   671 GADKMWKNPQDRQRSFLHQAVISGSVMACEFLLLNGAAIDAVDEMGYSALHISTAKGHIAQVYLL 735
            |||..|.|..:.|.:.|.|||:.||::.|||||.|||.::..|..|...||.:|..||..||.|.
Mouse   667 GADVNWANSDENQATPLIQAVLGGSLVTCEFLLQNGANVNQRDVQGRGPLHHATVLGHTGQVCLF 731

  Fly   736 LKHKAAYDLSSSDGKKALDIAVDQENADIVTLLRLTQLNDEIGPNDEYNGE--DETYKNVMKDFS 798
            ||..|....:..:||..|.|||:..||||||||||.::|:|:..::...|:  ||||:::.:|||
Mouse   732 LKRGANQHATDEEGKDPLSIAVEAANADIVTLLRLARMNEEMRESEGLYGQPGDETYQDIFRDFS 796

  Fly   799 KLPASQTRVL-RQRHDS 814
            ::.::....| |.:.||
Mouse   797 QMASNNPEKLNRFQQDS 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	78/198 (39%)
		PH	259..352	CDD:278594	51/100 (51%)
		PH_ACAP	260..355	CDD:270070	53/102 (52%)
		ArfGap	384..497	CDD:279720	75/125 (60%)
		ANK	652..768	CDD:238125	55/115 (48%)
		Ank_4	683..736	CDD:290365	25/52 (48%)
		ANK repeat	687..713	CDD:293786	14/25 (56%)
		ANK repeat	715..746	CDD:293786	12/30 (40%)
Acap2	XP_006522806.1	BAR_ACAP2	18..217	CDD:153322	78/198 (39%)
		PH_ACAP	273..376	CDD:270070	54/103 (52%)
		COG5347	398..>635	CDD:227651	104/282 (37%)
		ArfGap_ACAP2	410..524	CDD:350076	72/118 (61%)
		Ank_4	648..699	CDD:372654	25/50 (50%)
		ANK repeat	676..709	CDD:293786	15/32 (47%)
		PTZ00322	680..>764	CDD:140343	39/83 (47%)
		ANK repeat	711..742	CDD:293786	12/30 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	191	1.000	Domainoid score	I3233
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8182
Inparanoid	1	1.050	496	1.000	Inparanoid score	I1377
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55583
OrthoDB	1	1.010	-	-		D124295at33208
OrthoFinder	1	1.000	-	-		FOG0000653
OrthoInspector	1	1.000	-	-		otm43002
orthoMCL	1	0.900	-	-		OOG6_101039
Panther	1	1.100	-	-	O	PTHR23180
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R258
SonicParanoid	1	1.000	-	-		X412
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.010