DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenB1A and smap1

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_021336343.1	Gene:	smap1 / 777731	ZFINID:	ZDB-GENE-060920-2	Length:	483	Species:	Danio rerio

Alignment Length:	407	Identity:	97/407 - (23%)
Similarity:	163/407 - (40%)	Gaps:	107/407 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 THHSRPQSTNAPNNSLPAKRRIHWEEFLKIPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRS 425
            :...:.|..|..:.::.:|       .|:...|.||.||.:..|||||.|||:.:||.|:|:||:
Zfish     5 SEREKAQKLNEQHQAILSK-------MLREDDNKYCADCEAKGPRWASWNLGVFICIRCAGIHRN 62

  Fly   426 LGVHYSKVRSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKP-TEQC-EIGVREAWIK 488
            ||||.|:|:|:.||.|..|.::.:..:||....::|||.:.::  .::| |:|. |..:|:.:.:
Zfish    63 LGVHISRVKSVNLDQWTPEQIQSVQSMGNTKARQLYEAHLPEN--FRRPQTDQAVEFFIRDKYER 125

  Fly   489 AKYVERRFVCGMPKPQELLASETAEVLSIDSGGVVEDGESGGSGIAKRATLSLGGTRKWAVKKLR 553
            .||.::..|.|..|      |..|.:.|:         .|..|..|:::.|     .|...||..
Zfish   126 KKYYDKNSVNGAIK------SSDAALPSV---------SSPSSQAAEKSKL-----EKEREKKKE 170

  Fly   554 RRQKQRSIPKTLSDDPSIYNTAKTGDELEDDDDDESIN------------------IPSMSLSIS 600
            .:::::...|  .:.|::....:     ||:..|..|:                  :.|.|....
Zfish   171 EKKREKDTDK--ENKPAVLEKKR-----EDNQIDSRISPKKSAEPAIDLLGLDAPTVGSASSGAG 228

  Fly   601 RDDLLVIGDDLAL---------------DRLETPGILGSDQES---------------------- 628
            ......|.|||.:               .::.:....||.|.|
Zfish   229 TSSAAPISDDLDIFGPMVSNPLPSNSNSSQVSSSKAAGSAQASSAGGAVAGATGTGSAAPAQGDL 293

  Fly   629 -----TDGESDAESPEELPFSQLDANQLLYMASVVHNLPVMCMAFALGADKMW--KNPQDRQRSF 686
                 |.|.|.||...:.|.|: |:...||.:|.|...|....|..:|..:|.  ..||...::|
Zfish   294 DLFSETSGNSKAEDSAKKPLSK-DSILSLYGSSTVPQQPAQATAMFMGPSQMQFPAQPQGNFQAF 357

  Fly   687 ------LHQAVISGSVM 697
                  :....:.|:||
Zfish   358 PGMGGAMPPTTMMGAVM 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287
		PH	259..352	CDD:278594
		PH_ACAP	260..355	CDD:270070
		ArfGap	384..497	CDD:279720	43/114 (38%)
		ANK	652..768	CDD:238125	14/54 (26%)
		Ank_4	683..736	CDD:290365	4/21 (19%)
		ANK repeat	687..713	CDD:293786	3/11 (27%)
		ANK repeat	715..746	CDD:293786
smap1	XP_021336343.1	ArfGap	18..132	CDD:307528	44/122 (36%)
smap1	XP_021336343.1	Med15	<329..>466	CDD:312941	10/46 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810