DRSC/TRiP Functional Genomics Resources

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Protein Alignment CenB1A and Appl1

DIOPT Version :10

Sequence 1:NP_524458.1 Gene:CenB1A / 42735 FlyBaseID:FBgn0039056 Length:828 Species:Drosophila melanogaster
Sequence 2:NP_660256.1 Gene:Appl1 / 72993 MGIID:1920243 Length:707 Species:Mus musculus


Alignment Length:491 Identity:110/491 - (22%)
Similarity:206/491 - (41%) Gaps:84/491 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 IEFEECLKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSL------ 63
            :..||.|:|||:.|..:...|.|...:...:.::.:..:...|:     :|:.:.|..|      
Mouse     7 LPIEETLEDSPQTRSLLGVFEEDATAISNYMNQLYQAMHRIYDA-----QNELSAATHLTSKLLK 66

  Fly    64 -WDLQQHFL--DNKNAHNALGKLIHCFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVKDYKG 125
             ::.|:..|  |::...:.|.:......|::..|.:|..|.:..::..:|.|.:.|:.::...|.
Mouse    67 EYEKQRFPLGGDDEVMSSTLQQFSKVIDELSSCHAVLSTQLADAMMFPISQFKERDLKEILTLKE 131

  Fly   126 HFLKVSEGYDNALIKNAQASKNRPQE--MQEAANILSASKSCFQHTALDYVNYITLAQARKVPSI 188
            .|...|..:|.|:.:.::.||.|..:  ..|....:..|:.....|.:.|...:...|.:|..::
Mouse   132 VFQIASNDHDAAINRYSRLSKKRENDKVKYEVTEDVYTSRKKQHQTMMHYFCALNTLQYKKKIAL 196

  Fly   189 LSTLLDYYQACVTYYHQGFDLCN-DFDEFFKNISEDLNALR----GDYQQLEKAMQNRHMS---- 244
            |..||.|.||.::::..|.:..| ..:||..||...:..:|    ||.:.:::.:::..::    
Mouse   197 LEPLLGYMQAQISFFKMGSENLNGQLEEFLANIGTSVQNVRREMDGDVETMQQTIEDLEVASDPL 261

  Fly   245 -----------VNRYCDSNTNSTSNKIEGYLFKKKSKGF--KTWCRRWFYLSDNQLVYRKRSNED 296
                       :||      |.|  :..|||..:...|.  .||.|::::.....|:.:.|.  |
Mouse   262 YLPDPDPTKFPINR------NLT--RKAGYLNARNKTGLVSSTWDRQFYFTQGGNLMSQARG--D 316

  Fly   297 SFSVMEEDLRICSVRPVNEGDRRFCFEVIS--PTKSHILQADSADMLSLWISALQHSIGAAIQHD 359
            ....:..|:..|||..|:..|||:||::.|  ..||.||||:|......||..:.:     |...
Mouse   317 VAGGLAMDIDNCSVMAVDCEDRRYCFQITSFDGKKSSILQAESKKDHEEWICTINN-----ISKQ 376

  Fly   360 STHHSRPQSTNAPNNS--------LPAKRRIHWEEFLKIPGNAYCCDCRSPEPRWASINLGITLC 416
            ......|:.|.|..|.        .|:.::.|  |.|: ||.    ..|.|..|.:|        
Mouse   377 IYLSENPEETAARVNQSALEAVTPSPSFQQRH--ESLR-PGG----QSRPPTARTSS-------- 426

  Fly   417 IECSGVHRSLGVHYSKVRSLTLDAWESENVKVMMEL 452
               ||   |||...:.:.:|:||:..:.:..:..::
Mouse   427 ---SG---SLGSESTNLAALSLDSLVAPDTPIQFDI 456

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CenB1ANP_524458.1 BAR_ACAPs 18..217 CDD:153287 41/210 (20%)
PH_ACAP 260..355 CDD:270070 30/98 (31%)
ArfGap_ACAP 381..497 CDD:350064 17/72 (24%)
ANKYR <647..>768 CDD:440430
ANK repeat 687..713 CDD:293786
ANK repeat 715..746 CDD:293786
Appl1NP_660256.1 Required for RAB5A binding. /evidence=ECO:0000250 1..428 102/458 (22%)
BAR_APPL1 20..234 CDD:153315 44/218 (20%)
BAR-PH_APPL 252..376 CDD:270067 35/138 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 397..433 15/56 (27%)
F&H. /evidence=ECO:0000250 403..414 3/13 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 466..490
PTB_APPL 489..624 CDD:269980
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 636..707
Blue background indicates that the domain is not in the aligned region.

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