DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenB1A and Smap2

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_598477.2	Gene:	Smap2 / 69780	MGIID:	1917030	Length:	428	Species:	Mus musculus

Alignment Length:	305	Identity:	87/305 - (28%)
Similarity:	135/305 - (44%)	Gaps:	71/305 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 NAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLDAWESENVKVMMELGNEVV 457
            |.:|.||:|..|||||.|:|:.:||.|:|:||:||||.|:|:|:.||.|..|.::.|.|:||...
Mouse    25 NKFCADCQSKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTQEQIQCMQEMGNGKA 89

  Fly   458 NRIYEARIGDDCGLKKPTEQCEIGVREAWIKAKYVERRFVCGM--------------PKPQELLA 508
            ||:|||.:.:.....:.....|..:|:.:.|.||::|.....:              |.|::.:.
Mouse    90 NRLYEAYLPETFRRPQIDPAVEGFIRDKYEKKKYMDRSLDINVLRKEKDDKWKRGNEPAPEKKME 154

  Fly   509 SETAEVLSIDSGGVVEDGESGGSGIAKRATLSLGGTRKWAVKKLRRRQKQRSIPKTLS------- 566
            ....|.:                              |...||...:..::|.||:.:
Mouse   155 PVVFEKV------------------------------KMPQKKEDAQLPRKSSPKSAAPVMDLLG 189

  Fly   567 -DDP---SIYNTAKTGDELEDDDDDESINIPSMSLSISRDDLLVIGDDLALDRLETPGILGSDQE 627
             |.|   ||.| :||.:.|| .|.|...::||.| |:||.         |:..:.|.|..||..|
Mouse   190 LDAPVACSIAN-SKTSNALE-KDLDLLASVPSPS-SVSRK---------AVGSMPTAGSAGSVPE 242

  Fly   628 STD--GESDAESPEELPFSQLDANQLLYM-ASVVHNLPVMCMAFA 669
            :.:  .|..::| ||....||..:.:|.: .|....:|...|..|
Mouse   243 NLNLFPEPGSKS-EETGKKQLSKDSILSLYGSQTPQMPAQAMFMA 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287
		PH	259..352	CDD:278594
		PH_ACAP	260..355	CDD:270070
		ArfGap	384..497	CDD:279720	44/103 (43%)
		ANK	652..768	CDD:238125	5/19 (26%)
		Ank_4	683..736	CDD:290365
		ANK repeat	687..713	CDD:293786
		ANK repeat	715..746	CDD:293786
Smap2	NP_598477.2	ArfGap	13..126	CDD:307528	43/100 (43%)
		Interaction with clathrin heavy chains	163..231		23/79 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..262		16/54 (30%)
		Med15	276..>416	CDD:312941	3/11 (27%)
		Interaction with PICALM. /evidence=ECO:0000269\|PubMed:16571680	339..428
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810