DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenB1A and Asap3

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_038967221.1	Gene:	Asap3 / 684122	RGDID:	1593929	Length:	903	Species:	Rattus norvegicus

Alignment Length:	842	Identity:	187/842 - (22%)
Similarity:	298/842 - (35%)	Gaps:	280/842 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWDLQQHFLDNKNAHNA 79
            ||.|......|..:|..:..|::|.|.......||..:|           :.::|:   :.|..|
  Rat    32 PRCRGAALAREEVLEGDQAILQRIKKAVRAIHSSGLGHV-----------ETEEHY---REAVEA 82

  Fly    80 LGKLIHCFQEMNKFHTILLDQASRTVLKNLSVFVKD----------DINQV-------------- 120
            ||. .|..|..::..|..|         ||:||.::          ::|.:
  Rat    83 LGN-SHLSQNSHELSTGFL---------NLAVFTREVAALFKNLVQNLNNIVSFPLDNLMKGHLR 137

  Fly   121 ---KDYKGHFLKVSEGYDNALIKNAQASKNR-------------PQEMQEAANILSASKSCFQHT 169
               .|.|.|..|..:.|:.   |.|:..|.|             .|:.|....:       ||..
  Rat   138 DGRHDSKKHLEKAWKDYET---KVAKLEKERDRARFPGGSHGAMSQDTQRERRV-------FQLH 192

  Fly   170 ALDYVNYITLAQARKVPSILSTLLDYYQACVTYYHQGFDLCNDFDEFFKNISEDLNALR-GDYQQ 233
            ..:|:.....:|.::.|..|.:|:.::.|...::..|:........|...::..::.|| ...::
  Rat   193 MCEYLVKAGESQVKQGPDFLQSLIKFFHAQHNFFQDGWKAAQSLSPFIDKLAASVHGLRQAQEEE 257

  Fly   234 LEKAMQ------------------NRHMSVNRYC----DSNTNSTSNKIEGYLFKKKSKGFKTWC 276
            |.|..|                  ||..|...|.    ..|....:.|: |:|:||.....:.|.
  Rat   258 LHKLTQLRDSLRGMLHLESREEHPNRKNSGGGYSIHQHQGNKQFGTEKV-GFLYKKSDGIRRVWQ 321

  Fly   277 RRWFYLSDNQLVYRKRSNEDSFSVMEED-----LRICSVRPVNEGDRRFCFEVISPTKSHILQAD 336
            :|...:....|..       |.|::...     |..|.||| |..|:| ||::::..:::...|:
  Rat   322 KRKCGVKYGCLTI-------SHSMVNRPPVKLALLTCQVRP-NPEDKR-CFDLVTHNRTYHFHAE 377

  Fly   337 SADMLSLWISALQHSIGAAIQHDSTHHSRPQS---------TNAPN---NSLPAKRRIHWEEFLK 389
            .......|:|.||:|...|:  .|..|..|..         ...|:   |.|.|       |...
  Rat   378 DELECEAWVSVLQNSKDEAL--SSAFHGEPSGGQWSWGTRLDTEPHDLTNMLVA-------EVKS 433

  Fly   390 IPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLDAWESENVKVMMELGN 454
            .|||.:||||.:.:|.|.|.|||:..||:||||||.|||.||:::|||||......:.:.:.:||
  Rat   434 RPGNDHCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRYSRIQSLTLDLLGPSELLLALNIGN 498

  Fly   455 EVVNRIYEARIGDDCGLKKPTEQCEIGVREAWIKAKYVERRFV-CGMPKPQELLASETAEVLSID 518
            ...|.:.||.:... |..||:.:.::..|..:|.|||||.:|. ...|:||:|   .|| :.|.|
  Rat   499 SHFNEVMEAHLPSH-GSPKPSAESDMSSRRNYIVAKYVEHKFARRSTPEPQKL---RTA-ICSRD 558

  Fly   519 SGGVVE---DGESGGSGIAKRATLSLGGTRKWAVKKLRRRQKQRSIPKTLSDDPSIYNTAKTGDE 580
            ...|:|   :|:..|
  Rat   559 LLSVLEAFANGQDFG-------------------------------------------------- 573

  Fly   581 LEDDDDDESINIPSMSLSISRDDLLVIGDDLALDRLETPGILGSDQESTDGESDAESPEELPFSQ 645
                                  .||             ||            .|.::|.||
  Rat   574 ----------------------QLL-------------PG------------PDGQAPGEL---- 587

  Fly   646 LDANQLLYMASVVHNLPVMCMAFALGADKMWKNPQDRQRSFLHQAVISGSVMACEFLLLNGAAID 710
              |..|....:...:||::                                   :||:.||..:|
  Rat   588 --ALHLAIRVASQASLPIV-----------------------------------DFLIQNGGHLD 615

  Fly   711 AVDEMGYSALHISTAKGHIAQVYLLLKHKAAYDLSSSDGKKALDIAVDQENADIVTLLRLTQ 772
            |....|.:|||.:...|.:..:.||||.:|.....::.|:.|||:|.::::.|...||...|
  Rat   616 AKAADGNTALHCAALHGQLDCLKLLLKGRAPMGAVNNAGETALDVARNKQHKDCEELLEQAQ 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	43/238 (18%)
		PH	259..352	CDD:278594	25/97 (26%)
		PH_ACAP	260..355	CDD:270070	25/99 (25%)
		ArfGap	384..497	CDD:279720	47/112 (42%)
		ANK	652..768	CDD:238125	24/115 (21%)
		Ank_4	683..736	CDD:290365	12/52 (23%)
		ANK repeat	687..713	CDD:293786	6/25 (24%)
		ANK repeat	715..746	CDD:293786	10/30 (33%)
Asap3	XP_038967221.1	BAR_ASAP3	35..243	CDD:153324	44/241 (18%)
		PH_ASAP	294..400	CDD:270071	28/117 (24%)
		ArfGap_ASAP3	423..543	CDD:350087	51/127 (40%)
		ANK repeat	550..583	CDD:293786	14/133 (11%)
		ANK repeat	585..618	CDD:293786	12/73 (16%)
		Ank_2	589..674	CDD:403870	26/119 (22%)
		ANK repeat	620..651	CDD:293786	10/30 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920