DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenB1A and asap3

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001352027.1	Gene:	asap3 / 664764	ZFINID:	ZDB-GENE-050913-39	Length:	991	Species:	Danio rerio

Alignment Length:	847	Identity:	180/847 - (21%)
Similarity:	311/847 - (36%)	Gaps:	238/847 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FEECLKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWDLQQHFL 71
            |:..:.|.   |..|:..|..:|..:..|:|:.|:.....:||..:|:|:..:...|.:|....|
Zfish    26 FQSKMSDC---RSTVAALEESLEQDQMSLQKMKKIVKAIHNSGLNHVENKEQYTEVLENLGNSHL 87

  Fly    72 DNKNAHNALGKL-------------IHCFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVKDY 123
            ...|...:.|.|             .:..|.:|...:..|:...::.|::..:.:|..:.  |.:
Zfish    88 SQDNNEVSTGFLNLAVFTREVTALFKNLVQNLNNIISFPLENVLKSELRDSRLELKKQME--KSW 150

  Fly   124 KGHFLKVSEGYDNALIKNAQASKNRPQ-----EMQEAANILSASKSCFQHTALDYVNYITLAQAR 183
            |.:..|:.:      ::..:..|.:..     :|.:.|..:...:..||....:|:..|...:.|
Zfish   151 KDYDAKIGK------LEKERREKQKQHGLIRLDMTDTAEDMERERRNFQLQMCEYLLKIQELKIR 209

  Fly   184 KVPSILSTLLDYYQACVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQQLEKAMQ--------- 239
            :.|.:|..|:.|:||.:.::..|.....:...|.:.::..::.:|  ::|.|:..|
Zfish   210 QGPDLLQGLIKYFQAQLNFFQDGLKAAENLGPFVEKLAASVHTVR--HEQDEEVKQLSQLRDSLR 272

  Fly   240 ------------NRHMSVNRYC----DSNTNSTSNKIEGYLFKKKSKGFKTWCRRWFYLSDNQLV 288
                        ||..|.:.|.    ..|....:.| .|:|.||.....|.|.:|...:....|.
Zfish   273 TQLQVDGKEDFLNRKNSGHGYSIHQPQGNKKYGTEK-SGFLLKKSDGIRKVWQKRKCGVKYGCLT 336

  Fly   289 YRKRSNEDSFSVMEE-----DLRICSVRPVNEGDRRFCFEVISPTKSHILQADSADMLSLWISAL 348
            .       |.|.:..     :|..|.||| |..::| .|::::..:::..||:......:|:|.|
Zfish   337 I-------SHSTINRPPAKLNLLTCQVRP-NPEEKR-TFDLVTHNRTYHFQAEDEQECMIWVSVL 392

  Fly   349 QHS----IGAAIQHDSTHHSRPQSTNAPNNSLPAKRRIHWEEFLKIPGNAYCCDCRSPEPRWASI 409
            |:|    :..|:..|.....        ::.|....|........:|||..||||.:|:|.|.|.
Zfish   393 QNSKEEALNTALGGDQLQFQ--------DSGLQELVRAVISGLRNLPGNESCCDCGAPDPTWLST 449

  Fly   410 NLGITLCIECSGVHRSLGVHYSKVRSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKP 474
            ||||..||||||:||.||||.|:::|||||...:..:.:.:.:||...|.|.|..:.:|.  .||
Zfish   450 NLGILTCIECSGIHRELGVHQSRIQSLTLDVLSTSELLLAVSIGNARFNDIMEVNLPNDA--VKP 512

  Fly   475 TEQCEIGVREAWIKAKYVERRFVCGMPKPQELLASETAEVLSIDSGGVVEDGESGGSGIAKRATL 539
            ..:.::..|:.:|.|||.|||:|
Zfish   513 LPKSDMTARKEYIVAKYAERRYV------------------------------------------ 535

  Fly   540 SLGGTRKWAVKKLRRRQKQRSIPKTLSDDPSIYNTAKTGDELEDDDDDESINIPSMSLSISRDDL 604
                                 :||..|:...:::|.::.|
Zfish   536 ---------------------LPKEHSEAYRVFDTVRSKD------------------------- 554

  Fly   605 LVIGDDLALDRLETPGILGSDQESTDGESDAESPEELPFSQLDANQLLYMASVVHNLPVMCMAFA 669
                            ::...|...:|| |...|..:|
Zfish   555 ----------------LVSLLQHYAEGE-DLSKPVAIP--------------------------- 575

  Fly   670 LGADKMWKNPQDRQRSFLHQAVISG---SVMACEFLLLNGAAIDAVDEMGYSALHISTAKGHIAQ 731
                    :.||.:.:.||.||...   |:...:||..|...::.....|.:|||..........
Zfish   576 --------DGQDLKETGLHLAVRMSDKTSLALVDFLAQNCGCLEKKTVEGNTALHYCALYKKTEC 632

  Fly   732 VYLLLKHKAAYDLSSSDGKKALDIAVDQENADIVTLLRLT---QLNDEIG-------PNDEYNGE 786
            :.||||.||.....:|.|:.|||||...::...:.||.|.   :.|.:|.       |.|.|:.|
Zfish   633 LKLLLKAKAVLHTVNSAGETALDIAKRLQHMQCIELLELAHSGKFNSQIHVEYTWEMPQDMYDSE 697

  Fly   787 DE 788
            |:
Zfish   698 DD 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	40/216 (19%)
		PH	259..352	CDD:278594	26/101 (26%)
		PH_ACAP	260..355	CDD:270070	25/103 (24%)
		ArfGap	384..497	CDD:279720	49/112 (44%)
		ANK	652..768	CDD:238125	27/118 (23%)
		Ank_4	683..736	CDD:290365	13/55 (24%)
		ANK repeat	687..713	CDD:293786	8/28 (29%)
		ANK repeat	715..746	CDD:293786	10/30 (33%)
asap3	NP_001352027.1	BAR_ASAP3	34..246	CDD:153324	41/219 (19%)
		PH_ASAP	297..403	CDD:270071	27/115 (23%)
		ArfGap	421..537	CDD:307528	51/180 (28%)
		ANK repeat	582..614	CDD:293786	8/31 (26%)
		ANK	<583..669	CDD:238125	25/85 (29%)
		ANK repeat	616..647	CDD:293786	10/30 (33%)
		Herpes_gI	<749..>858	CDD:332941
		SH3	933..985	CDD:327375
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920