Protein Alignment CenB1A and Agap2

DIOPT Version :10

• Sequence 1: NP_524458.1
• Gene: CenB1A / 42735
• FlyBaseID: FBgn0039056
• Length: 828
• Species: Drosophila melanogaster
• Sequence 2: NP_075415.2
• Gene: Agap2 / 65218
• RGDID: 628844
• Length: 1186
• Species: Rattus norvegicus
• Alignment Length: 273
• Identity: 84/273 - (30%)
• Similarity: 126/273 - (46%)
• Gaps: 52/273 - (19%)

  Fly   255 STSNKIEGYLFKKKSKGFKTWCRRWFYLSDNQLVYRKRSNEDSFSVMEEDLRICSVRPVNEGDRR 319
            ||.:|.||...:.::|                   ||.....||.         |:|.:.:.:..
  Rat   833 STPSKTEGSAVQAEAK-------------------RKMWKLKSFG---------SLRNIYKAEEN 869

  Fly   320 FCFEVISPT-KSHILQADSADMLSLWISALQHSIGAAIQ--HDSTHHSRPQSTNAPNNSLPAKRR 381
            |.|.::|.| ::...:|.|.:....|:.|::..|.|::|  ..|....|..|.:         ..
  Rat   870 FEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQS---------EA 925

  Fly   382 IHWEEFLKIPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLDAWESENV 446
            :..:......||:.|.||.:|.|.|||:|||..:||||||:||:||.|.|:||||.||.|..|..
  Rat   926 VAIQAIRNAKGNSTCVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELT 990

  Fly   447 KVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEIGVREAWIKAKYVERRFVCGMPKPQELL---- 507
            .|:..:||:..||::|:   |..|..|||.......||:||:|||.:..|:..:...:|.|
  Rat   991 LVLTAIGNDTANRVWES---DTRGRAKPTRDSSREERESWIRAKYEQLLFLAPLGTTEEPLGRQL 1052

  Fly   508 -----ASETAEVL 515
                 |.:.|.||
  Rat  1053 WAAVEAQDVAAVL 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287
		PH_ACAP	260..355	CDD:270070	18/95 (19%)
		ArfGap_ACAP	381..497	CDD:350064	51/115 (44%)
		ANKYR	<647..>768	CDD:440430
		ANK repeat	687..713	CDD:293786
		ANK repeat	715..746	CDD:293786
Agap2	NP_075415.2	Interaction with EPB41L1. /evidence=ECO:0000269|PubMed:11136977	1..23
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..371
		PRK07764	<37..174	CDD:236090
		Interactions with HOMER1 and NF2	180..225
		Interaction with PLCG1. /evidence=ECO:0000269|PubMed:11823862	262..384
		G domain. /evidence=ECO:0000250	399..566
		Centaurin_gamma	401..560	CDD:133303
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	576..613
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	628..666
		PH_AGAP	668..908	CDD:241281	22/102 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	759..784
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	800..844		5/10 (50%)
		ArfGap_AGAP	926..1033	CDD:350065	50/109 (46%)
		ANKYR	<1082..>1141	CDD:440430
		ANK repeat	1084..1115	CDD:293786
		ANK 1	1084..1113
		ANK 2	1117..1146
		ANK repeat	1117..1142	CDD:293786
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1145..1174