DRSC/TRiP Functional Genomics Resources

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Protein Alignment CenB1A and SMAP2

DIOPT Version :9

Sequence 1:NP_524458.1 Gene:CenB1A / 42735 FlyBaseID:FBgn0039056 Length:828 Species:Drosophila melanogaster
Sequence 2:NP_073570.1 Gene:SMAP2 / 64744 HGNCID:25082 Length:429 Species:Homo sapiens


Alignment Length:313 Identity:89/313 - (28%)
Similarity:138/313 - (44%) Gaps:86/313 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   393 NAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLDAWESENVKVMMELGNEVV 457
            |.:|.||:|..|||||.|:|:.:||.|:|:||:||||.|:|:|:.||.|..|.::.|.|:||...
Human    25 NKFCADCQSKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTQEQIQCMQEMGNGKA 89

  Fly   458 NRIYEARIGDDCGLKKPTEQCEIGVREAWIKAKYVERRFVCGMPKPQELLASETAEVLSIDSGGV 522
            ||:|||.:.:.....:.....|..:|:.:.|.||::|                     |:|....
Human    90 NRLYEAYLPETFRRPQIDPAVEGFIRDKYEKKKYMDR---------------------SLDINAF 133

  Fly   523 VEDGESGGSGIAKRATLSLGGTRKW---------------AVKKLRRRQK-------QRSIPKTL 565
            .::.:.                 ||               ..:|::..||       ::|.||:.
Human   134 RKEKDD-----------------KWKRGSEPVPEKKLEPVVFEKVKMPQKKEDPQLPRKSSPKST 181

  Fly   566 S--------DDP---SIYNTAKTGDELEDDDDDESINIPSMSLSISRDDLLVIGDDLALDRLETP 619
            :        |.|   ||.| :||.:.|| .|.|...::||.|.|.||.   |:|.      :.|.
Human   182 APVMDLLGLDAPVACSIAN-SKTSNTLE-KDLDLLASVPSPSSSGSRK---VVGS------MPTA 235

  Fly   620 GILGSDQESTD--GESDAESPEELPFSQLDANQLLYM-ASVVHNLPVMCMAFA 669
            |..||..|:.:  .|..::| ||:...||..:.:|.: .|....:|...|..|
Human   236 GSAGSVPENLNLFPEPGSKS-EEIGKKQLSKDSILSLYGSQTPQMPTQAMFMA 287

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CenB1ANP_524458.1 BAR_ACAPs 18..217 CDD:153287
PH 259..352 CDD:278594
PH_ACAP 260..355 CDD:270070
ArfGap 384..497 CDD:279720 44/103 (43%)
ANK 652..768 CDD:238125 5/19 (26%)
Ank_4 683..736 CDD:290365
ANK repeat 687..713 CDD:293786
ANK repeat 715..746 CDD:293786
SMAP2NP_073570.1 ArfGap_SMAP2 16..122 CDD:350083 41/96 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 138..184 8/62 (13%)
Interaction with clathrin heavy chains. /evidence=ECO:0000250 163..232 24/79 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 217..259 17/51 (33%)
Interaction with PICALM. /evidence=ECO:0000250 340..429
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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