DRSC/TRiP Functional Genomics Resources

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Protein Alignment CenB1A and ARAP3

DIOPT Version :9

Sequence 1:NP_524458.1 Gene:CenB1A / 42735 FlyBaseID:FBgn0039056 Length:828 Species:Drosophila melanogaster
Sequence 2:NP_071926.4 Gene:ARAP3 / 64411 HGNCID:24097 Length:1544 Species:Homo sapiens


Alignment Length:311 Identity:82/311 - (26%)
Similarity:123/311 - (39%) Gaps:72/311 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   282 LSDNQLVYRKRSNEDSFS----VMEEDLRICSVRPVNEGDRRFCFEVISPTKSHILQADSADMLS 342
            ||..:|...|  :|.:||    :...:|:.||||......    |::::|.:.....|:|.....
Human   414 LSPGELALYK--SEQAFSLGIGICFIELQGCSVRETKSRS----FDLLTPHRCFSFTAESGGARQ 472

  Fly   343 LWISALQHSIGAAIQHDSTHHSRPQSTNAPNNSLPAKRRIHWEEFLKIPGNAYCCDCRSPEPRWA 407
            .|.:|||.::...:                 :......:| |..    ..|..|.||.|..|.||
Human   473 SWAAALQEAV
TETL-----------------SDYEVAEKI-WSN----RANRQCADCGSSRPDWA 515

  Fly   408 SINLGITLCIECSGVHRSLGVHYSKVRSLTLD--AWESENVKVMMELGNEVVNRIYEARIGDDCG 470
            ::|||:.:|.:|:|.||:||...|||:||.||  .|.:|.|::.:.|||:..||.:...:....|
Human   516 AVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRANRFWAGTLPPGEG 580

  Fly   471 LKKPTEQCEIGVREAWIKAKYVERRFVCGMPKPQ-----ELLASETAEVLSIDSGGVVEDGESGG 530
            |......   |.|..:|..||  |..:...|.||     :||.:..|.|                
Human   581 LHPDATP---GPRGEFISRKY--RLGLFRKPHPQYPDHSQLLQALCAAV---------------- 624

  Fly   531 SGIAKRATLSLGGTRKWAVKKLRRRQ------KQRSIPKTLSDDPS--IYN 573
                .|..|....|:...|:.....:      ...|.|..|..|||  :||
Human   625 ----ARPNLLKNMTQLLCVEAFEGEEPWFPPAPDGSCPGLLPSDPSPGVYN 671

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CenB1ANP_524458.1 BAR_ACAPs 18..217 CDD:153287
PH 259..352 CDD:278594 20/73 (27%)
PH_ACAP 260..355 CDD:270070 20/76 (26%)
ArfGap 384..497 CDD:279720 42/114 (37%)
ANK 652..768 CDD:238125
Ank_4 683..736 CDD:290365
ANK repeat 687..713 CDD:293786
ANK repeat 715..746 CDD:293786
ARAP3NP_071926.4 SAM_Arap1,2,3 4..66 CDD:188889
SAM 12..64 CDD:197735
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 64..147
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 167..194
PH 288..379 CDD:278594
PH1_ARAP 289..381 CDD:270073
PH2_ARAP 398..479 CDD:270074 18/70 (26%)
PH 399..482 CDD:278594 20/73 (27%)
ArfGap 490..606 CDD:279720 43/125 (34%)
PH3_ARAP 676..786 CDD:270076
PH-like <846..894 CDD:302622
RhoGAP_ARAP 909..1084 CDD:239850
RA 1117..1209 CDD:279168
PH5_ARAP 1212..1331 CDD:270079
PH 1241..1325 CDD:278594
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1422..1544
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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