Protein Alignment CenB1A and Acap2

DIOPT Version :10

• Sequence 1: NP_524458.1
• Gene: CenB1A / 42735
• FlyBaseID: FBgn0039056
• Length: 828
• Species: Drosophila melanogaster
• Sequence 2: XP_006248549.1
• Gene: Acap2 / 619382
• RGDID: 1562939
• Length: 812
• Species: Rattus norvegicus
• Alignment Length: 858
• Identity: 336/858 - (39%)
• Similarity: 486/858 - (56%)
• Gaps: 93/858 - (10%)

  Fly     1 MRATIEFEECLKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWD 65
            |:.|::||||||||||||..:.:.|.|:..||.:|:|::|||...:|:||.:......|...:.|
  Rat     1 MKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCAANKQFMNGIRD 65

  Fly    66 LQQHFLDNKNAHNALGKLIHCFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVKDYKGHFLKV 130
            |.|:..::.....:|.|.....|||..|||||.||..|::...|..|||:|:.:.||.|..|.||
  Rat    66 LAQYSSNDAVVETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKFKDAKKQFEKV 130

  Fly   131 SEGYDNALIKNAQASKNRPQEMQEAANILSASKSCFQHTALDYVNYITLAQARKVPSILSTLLDY 195
            ||..:|||:||||..:|:..|::||||||:|::.||:|.|||||..|.:.|:::...||.::|.:
  Rat   131 SEEKENALVKNAQVQRNKQHEVEEAANILTATRKCFRHIALDYVLQINVLQSKRRSEILKSMLSF 195

  Fly   196 YQACVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQQLEKAMQNRHMSVNRYCDSNTNS----- 255
            ..|.:.::|||:||.::...:.|::...|:.|..|..:.::.|:.:|.::.:...|:.:|
  Rat   196 MYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKREMEQKHSTIQQKDFSSDDSKLEYN 260

  Fly   256 --TSNKI--EGYLFKKKSKGFKTW-------CRRWFYLSDNQLVYRKRSNEDSFSVMEEDLRICS 309
              .:|.|  ||||||:.|..||||       .||||.:.:|||||:|:. :||.:|:.||||:|:
  Rat   261 VDAANGIVMEGYLFKRASNAFKTWNRKKPDHIRRWFSIQNNQLVYQKKF-KDSPTVVVEDLRLCT 324

  Fly   310 VRPVNEGDRRFCFEVISPTKSHILQADSADMLSLWISALQHSIGAAIQHDSTH------HSRPQS 368
            |:...:.:|||||||:|||||.:|||||..:...||.|:|.||..|.:.....      .|.|.:
  Rat   325 VKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPST 389

  Fly   369 TNAPNNSLPAKRRIHWEEFLK----IPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVH 429
            .:..:.|...::.:..|..|:    ||||..||||...:||||||||||||||||||:|||||||
  Rat   390 GSLDSGSESKEKLLKGESALQRVQCIPGNTSCCDCGLADPRWASINLGITLCIECSGIHRSLGVH 454

  Fly   430 YSKVRSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEIGVR---EAWIKAKY 491
            :|||||||||.||.|.:|:|.||||:|:||:|||:: :..|:|||    :.|.|   ||:|:|||
  Rat   455 FSKVRSLTLDTWEPELLKLMCELGNDVINRVYEAKL-EKMGVKKP----QPGQRQEKEAYIRAKY 514

  Fly   492 VERRFVCGMPKPQELLASETAEVLSIDSGGVVEDGESGGSGIAKRATLSLGGTRKWAVKKLRRRQ 556
            |||:||   .|...||:....|...|...  .||.....:.::....::       ||.....|:
  Rat   515 VERKFV---DKYSTLLSPSEQEKRIISKS--CEDQRLSHTRVSVHTPVA-------AVNSDEARR 567

  Fly   557 KQRSIPKTLSDDPSIYNTA------KTGDE-LEDDDDDESINIPSMSLSISRDDLLVIGDDLALD 614
            :....|..|....|.::|:      |:.|. ::...||...::||   ::|.:.|.
  Rat   568 ESLFCPDELDSLFSYFDTSSKLRSIKSNDSGIQQCSDDGRESLPS---TVSANSLY--------- 620

  Fly   615 RLETPGILGSDQESTDGESDAESPEELPFSQLDANQL-----LYMASVVHNLPVMCMAFALGADK 674
                             |.:.|..|...|  ||:..|     ||.||...|||.|..|.|.|||.
  Rat   621 -----------------EPEGERQESSVF--LDSKHLNPGLQLYRASYEKNLPKMAEALAHGADV 666

  Fly   675 MWKNPQDRQRSFLHQAVISGSVMACEFLLLNGAAIDAVDEMGYSALHISTAKGHIAQVYLLLKHK 739
            .|.|..:.|.:.|.|||:.||::.|||||.|||.::..|..|...||.:|..||..||.|.||..
  Rat   667 NWANSDENQATPLIQAVLGGSLVTCEFLLQNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRG 731

  Fly   740 AAYDLSSSDGKKALDIAVDQENADIVTLLRLTQLNDEIGPNDEYNGE--DETYKNVMKDFSKLPA 802
            |....:..:||..|.|||:..||||||||||.::|:|:..::...|:  ||||:::.:|||::.:
  Rat   732 ANQHATDEEGKDPLSIAVEAANADIVTLLRLARMNEEMRESEGLYGQPGDETYQDIFRDFSQMAS 796

  Fly   803 SQTRVL-RQRHDS 814
            :....| |.:.||
  Rat   797 NNPEKLNRFQQDS 809

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	78/198 (39%)
		PH_ACAP	260..355	CDD:270070	54/103 (52%)
		ArfGap_ACAP	381..497	CDD:350064	74/122 (61%)
		ANKYR	<647..>768	CDD:440430	57/125 (46%)
		ANK repeat	687..713	CDD:293786	14/25 (56%)
		ANK repeat	715..746	CDD:293786	12/30 (40%)
Acap2	XP_006248549.1	BAR_ACAP2	18..217	CDD:153322	78/198 (39%)
		PH_ACAP	269..372	CDD:270070	54/103 (52%)
		ArfGap_ACAP2	406..520	CDD:350076	74/118 (63%)
		ANKYR	<644..775	CDD:440430	61/130 (47%)
		ANK repeat	672..705	CDD:293786	15/32 (47%)
		ANK repeat	707..738	CDD:293786	12/30 (40%)