DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenB1A and appl1

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_021335332.1	Gene:	appl1 / 571540	ZFINID:	ZDB-GENE-081016-1	Length:	708	Species:	Danio rerio

Alignment Length:	448	Identity:	101/448 - (22%)
Similarity:	185/448 - (41%)	Gaps:	53/448 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IEFEECLKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWDLQ-Q 68
            :..||.|:|||:.|..:...|.|...:.....::.|......|:..|........:..|.|.: |
Zfish     7 LPIEETLEDSPQTRSLLGVFEEDAAAISSYFNQLFKAMQRIYDAQNELSAATHLTSKLLKDYEKQ 71

  Fly    69 HFL---DNKNAHNALGKLIHCFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVKDYKGHFLKV 130
            .|.   |::...:.|.:......|::..|.:|..|.:..::..::.|.:.|:.::...|..|...
Zfish    72 RFPLGGDDEVMSSTLQQFAKVIDELSSCHAVLSTQLADAMMFPITQFQERDLREILILKEVFQLA 136

  Fly   131 SEGYDNALIKNAQASKNRPQE--MQEAANILSASKSCFQHTALDYVNYITLAQARKVPSILSTLL 193
            |:.:|.|:.:.::.||.:..|  ..|....:..|:.....|.:.|...:.:.|.:|..::|..||
Zfish   137 SDDHDAAVHRYSRLSKRKENEKVKNEVMEDVYTSRKKQHETTMHYFASLNMLQYKKKIALLEPLL 201

  Fly   194 DYYQACVTYYHQGFD-LCNDFDEFFKNISEDLNALR----GDYQQLEKAMQN-RHMSVNRYC--- 249
            .|.||.::::..|.: |...:::|..||...:..:|    .|.:.:|:.:|: :..|...|.
Zfish   202 GYMQAQISFFKLGSENLTQQWEDFLTNIGTSVQNVRREMDSDAEAMEQTIQDLKEASDPLYMPDP 266

  Fly   250 DSN---TNSTSNKIEGYLFKKKSKGF--KTWCRRWFYLSDNQLVYRKRSNEDSFSVMEEDLRICS 309
            |.|   .|....:..|||..:...|.  .:|.|::|:.....|:.:.|.......||  |:..||
Zfish   267 DPNRIPVNRNLTRKAGYLNTRNKTGLVSSSWERQYFFTQGGNLMSQSRGAVAGGLVM--DIDNCS 329

  Fly   310 VRPVNEGDRRFCFEV--ISPTKSHILQADSADMLSLWISALQH------------SIGAAIQHDS 360
            |..|:..||||||::  ....|:.:|||||......||:.:.:            .|.|.:...:
Zfish   330 VMAVDCEDRRFCFQITAFDGKKAAVLQADSRKDCEEWIATINNISKRIYLSENPEEIAARVNQSA 394

  Fly   361 THHSRPQSTNAPNNSLPAKRRIHWEEF-------LKIPGNAYCCDCRSPEPRWASINL 411
            .....|.         |:.::.| |.|       :|...:...|...|..|..:|::|
Zfish   395 LEAVTPS---------PSFQQRH-ESFRPNTQGKVKASRSGSQCSVGSESPALSSLSL 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	40/205 (20%)
		PH	259..352	CDD:278594	30/108 (28%)
		PH_ACAP	260..355	CDD:270070	31/110 (28%)
		ArfGap	384..497	CDD:279720	8/35 (23%)
		ANK	652..768	CDD:238125
		Ank_4	683..736	CDD:290365
		ANK repeat	687..713	CDD:293786
		ANK repeat	715..746	CDD:293786
appl1	XP_021335332.1	BAR_APPL1	20..234	CDD:153315	43/213 (20%)
		BAR-PH_APPL	252..376	CDD:270067	36/125 (29%)
		PTB_APPL	488..623	CDD:269980
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900