DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenB1A and asap2a

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_021322892.1	Gene:	asap2a / 570669	ZFINID:	ZDB-GENE-041210-256	Length:	1003	Species:	Danio rerio

Alignment Length:	897	Identity:	188/897 - (20%)
Similarity:	318/897 - (35%)	Gaps:	252/897 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SPRFRQFVSKE---ESDIEHLEQRLE-------KIIKLCNVAVDSGKEYVKNQSAFAMSLW---- 64
            ||....|.::.   .:.:..||:.|:       |:.|.......||..:|:|:..:..:|.
Zfish    20 SPTASNFTTRMTHCRNTVSALEEALDVDRSVLYKMKKSVKAIYASGLAHVENEEQYTQALEKFGE 84

  Fly    65 --------DLQQHFLDNKNAHNALGKLI-HCFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQV 120
                    ||...||........|..|. :.||.||...|..||...:..||.    ||.|:.:.
Zfish    85 NCVYRDDPDLGSAFLKFSVFTKELTALFKNLFQNMNNIITFPLDSLLKGDLKG----VKGDLKKP 145

  Fly   121 --KDYKGHFLKVSEGYDNALIKNAQASKNRPQEMQ------------EAANILSASKSCFQHTAL 171
              |.:|.:..||.:|:  :|:|.::..|.:.:..:            |.|..:...:..||....
Zfish   146 FDKAWKDYETKVCKGH--SLLKGSKIEKEKKEHARQHGMIRTEISGAEIAEEMEKERRFFQLQMC 208

  Fly   172 DYVNYITLAQARKVPSILSTLLDYYQACVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQQ--- 233
            :|:..:...:.:|...:|..|:.|:.|...::..|....::.....:.::.||::::....:
Zfish   209 EYLLKVNEIKIKKGVDLLQNLIKYFHAQCNFFQDGLKAVDNLKPSIEKLATDLHSIKQVQDEERR 273

  Fly   234 --------LEKAMQNRHMSVNRYCDSNTNSTS---------NK-----IEGYLFKKKSKGFKTWC 276
                    |:.|:|.......|  ||....::         ||     ..|.|:||.....|.|.
Zfish   274 QLTQLRDVLKTALQVEQKESRR--DSQVRQSATYSLHQPQGNKEHGTERSGNLYKKSDGLRKVWQ 336

  Fly   277 RRWFYLSDNQL-VYRKRSNEDSFSVMEEDLRICSVRPVNEGDRRFCFEVISPTKSHILQADSADM 340
            :|...:.:..| :....:|.....:   :|..|.|:  :..:.:..|::||..:::..||:....
Zfish   337 KRKCTVKNGYLTISHGTANRPPAKL---NLLTCQVK--HNPEEKKSFDLISHDRTYHFQAEDEPE 396

  Fly   341 LSLWISALQHSIGAAI-------QHDSTHHSRPQSTNAPNNSLPAKRRIHWEEFLKIPGNAYCCD 398
            ..:|||.||:|...|:       ||           ...||.:....:....|..::.||..|||
Zfish   397 CQIWISVLQNSKEEALNNAFKGDQH-----------VGENNIVQELTKAILGEVKRMAGNDVCCD 450

  Fly   399 CRSPEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLDAWESENVKVMMELGNEVVNRIYEA 463
            |.:|.|.|.|.||||..||||||:||.||||||:::|||||...:..:.:...:||...|.|.||
Zfish   451 CGAPGPTWLSTNLGILTCIECSGIHRELGVHYSRIQSLTLDVLSTSELLLAKNVGNAGFNEIMEA 515

  Fly   464 RI-GDDCGLKKPTEQCEIGVREAWIKAKYVERRFVCGMPKPQELLASETAEVLSIDSGGVVEDGE 527
            .: .:|  :.||....::..|:.:|.|||.|:||.
Zfish   516 CLTAED--VIKPNPASDMQARKDFIMAKYTEKRFA------------------------------ 548

  Fly   528 SGGSGIAKRATLSLGGTRKWAVKKLRRRQKQRSIPKTLSDDPSIYNTAKTGDELEDDDDDESINI 592
                                          ::..|..||...::.:..|..|
Zfish   549 ------------------------------RKKCPDALSKLHTLCDAVKARD------------- 570

  Fly   593 PSMSLSISRDDLLVIGDDLALDRLETPGILGSDQESTDGESDAESPEELPFSQLDANQLLYMASV 657
                                                             .||
Zfish   571 -------------------------------------------------IFS------------- 573

  Fly   658 VHNLPVMCMAFALGADKM----WKNPQDRQRSFLHQA---VISGSVMACEFLLLNGAAIDAVDEM 715
                  :...:|.|.|.|    ..|..::..:.||.|   |...|:...:||..|...:|.....
Zfish   574 ------LIQVYAEGVDLMEPIPLANGHEQGETALHLAVRLVDRTSLHIIDFLTQNSLNLDKQTAK 632

  Fly   716 GYSALHISTAKGHIAQVYLLLKHKAAYDLSSSDGKKALDIAVDQENADIVTLLRLT---QLNDEI 777
            |.:|||......:...:.|||:.||:.|:::..|:..||||...::.....||...   :.|..:
Zfish   633 GSTALHYCCLTDNSECLKLLLRGKASIDIANEAGETPLDIARRLKHLQCEELLNQALAGKFNAHV 697

  Fly   778 GPNDEYNGEDETYKNVMKDFSKLPASQTRVLR----QRHDSNTLESQRSSLT 825
            ....|:..:.|......:|..:..:...|..|    ....||:|:...:||:
Zfish   698 HVEYEWRLQHEDLDESDEDLDEKSSPHRRDERPISCYTPGSNSLQLSPASLS 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	48/235 (20%)
		PH	259..352	CDD:278594	23/98 (23%)
		PH_ACAP	260..355	CDD:270070	23/95 (24%)
		ArfGap	384..497	CDD:279720	50/113 (44%)
		ANK	652..768	CDD:238125	29/122 (24%)
		Ank_4	683..736	CDD:290365	14/55 (25%)
		ANK repeat	687..713	CDD:293786	9/28 (32%)
		ANK repeat	715..746	CDD:293786	10/30 (33%)
asap2a	XP_021322892.1	BAR_ASAP2	34..257	CDD:153326	47/228 (21%)
		PH_ASAP	309..415	CDD:270071	26/110 (24%)
		ArfGap	433..550	CDD:307528	51/178 (29%)
		ANK repeat	562..594	CDD:293786	9/112 (8%)
		ANK	<597..685	CDD:238125	24/87 (28%)
		ANK repeat	597..630	CDD:293786	9/32 (28%)
		ANK repeat	632..663	CDD:293786	10/30 (33%)
		SH3	945..1000	CDD:327375
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820