DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenB1A and git1

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_697386.4	Gene:	git1 / 568935	ZFINID:	ZDB-GENE-100408-5	Length:	761	Species:	Danio rerio

Alignment Length:	464	Identity:	93/464 - (20%)
Similarity:	152/464 - (32%)	Gaps:	174/464 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   389 KIPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLDAWESENVKVMMELG 453
            |:..:..|.||.:|:|.|:|||.|:.:|.||..||||||.|.|.|:.|....|....::::..|.
Zfish     4 KVQRSEVCADCSAPDPGWSSINRGVLICDECCSVHRSLGRHISIVKHLRHSGWPPSLLQMVQTLA 68

  Fly   454 NEVVNRIYEARIGD----DCGLKKPTEQCEI-GVREAWIKAKYVERRFVCGMPKPQELLASETAE 513
            :...|.|:|..:.|    ..|.:||..|.:: ..:..:|:|||....||..:|
Zfish    69 SNGANSIWEHSLLDPAQVQSGRRKPNPQDKVHPTKSEFIRAKYQMLAFVHKLP------------ 121

  Fly   514 VLSIDSGGVVEDGESGGSGIAKRATLSLGGTRKWAVKKLRRRQKQRSIPKTLSDDPSIYNTAKTG 578
              ..|..||.                                      .|.||  ..::::.:||
Zfish   122 --CRDDDGVT--------------------------------------TKDLS--KQLHSSVRTG 144

  Fly   579 DELEDDDDDESINIPSMSLSISRDDLLVIGDDLALDRLETPGILGSDQESTDGESDAESPEELPF 643
            .                                    |||
Zfish   145 S------------------------------------LET------------------------- 148

  Fly   644 SQLDANQLLYMASVVHNLPVMCM-AFALGADKMWKNPQDRQRSFLHQAVISGSVMACEFLLLNGA 707
                                 |: ..:|||...:.:| ::..:.||.|..:|.|:..|.|::.||
Zfish   149 ---------------------CLRLLSLGAQANFFHP-EKGTTPLHVAAKAGQVLQAELLVVYGA 191

  Fly   708 AIDAVDEMGYSALHISTAKGHIAQVYLLLKHKAAYDLSSSDGKKALDIAVDQENADIVTLLRLTQ 772
            ...|.|..|.:.:..:...||:.....|:  :..|:|:............|.:|...:    :.|
Zfish   192 DPGAPDINGRTPIDYARQAGHVELAERLV--ECQYELTDRLAFYLCGRRPDHKNGHYI----IPQ 250

  Fly   773 LNDEIGPNDEYNGED--ETYKNVMKDFSKLPASQTRVL------------RQRHDS--------N 815
            :.|...|.......|  |..|...|   ||.|...|:.            |:.:|:        :
Zfish   251 MADRARPKCPTQSLDLSELAKAAKK---KLQALNNRLFEELAMDVYDEVDRRENDAVWLTTQNHS 312

  Fly   816 TLESQRSSL 824
            ||.::||::
Zfish   313 TLVTERSAV 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287
		PH	259..352	CDD:278594
		PH_ACAP	260..355	CDD:270070
		ArfGap	384..497	CDD:279720	38/112 (34%)
		ANK	652..768	CDD:238125	24/116 (21%)
		Ank_4	683..736	CDD:290365	14/52 (27%)
		ANK repeat	687..713	CDD:293786	10/25 (40%)
		ANK repeat	715..746	CDD:293786	6/30 (20%)
git1	XP_697386.4	ArfGap	3..124	CDD:214518	41/133 (31%)
		ANK	<123..220	CDD:238125	30/219 (14%)
		Ank_2	137..229	CDD:289560	27/176 (15%)
		ANK repeat	137..165	CDD:293786	10/110 (9%)
		ANK repeat	167..197	CDD:293786	10/29 (34%)
		GIT_SHD	<281..301	CDD:285690	2/19 (11%)
		GIT_SHD	337..364	CDD:285690
		GIT_CC	416..479	CDD:293167
		GIT1_C	639..754	CDD:289013
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810