DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenB1A and acap2a

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_005163306.1	Gene:	acap2a / 564814	ZFINID:	ZDB-GENE-081104-34	Length:	824	Species:	Danio rerio

Alignment Length:	859	Identity:	324/859 - (37%)
Similarity:	467/859 - (54%)	Gaps:	99/859 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRATIEFEECLKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWD 65
            |:.|::||||||||||||..:...|.|...||.:|:|::|||...:|:|:.|.:....|...:.|
Zfish     1 MKVTVDFEECLKDSPRFRATIEDVEEDFGELESKLDKLVKLCIGMIDAGRVYNQANKQFVNGIRD 65

  Fly    66 LQQHFLDNKNAHNALGKLIHCFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVKDYKGHFLKV 130
            |......::...::|.......||||.:||||.|||.|::...|..|||:|:.:.||.|..|.||
Zfish    66 LALQSTRDEVIGSSLAAFSETLQEMNNYHTILFDQAQRSIRSQLQTFVKEDLRKFKDAKKQFDKV 130

  Fly   131 SEGYDNALIKNAQASKNRPQEMQEAANILSASKSCFQHTALDYVNYITLAQARKVPSILSTLLDY 195
            ||..:.||:||||..:|:..|::||.|||:.::..|::.|||||..|.:.|:::...||.::|.|
Zfish   131 SEEKEVALVKNAQVPRNKLHEVEEATNILTTTQKFFRNIALDYVLQINVLQSKRRLEILKSMLAY 195

  Fly   196 YQACVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQQLEKAMQNRHMSVNRYC---DSNTN--- 254
            ..|.:|:::||.||.:......|.:|..|:.|..|..:.::.|:.:|.|:.:..   |.:|.
Zfish   196 MNANLTFFNQGHDLFSQLQPLMKQLSGQLDQLVVDSAKEKRDMEQKHSSIQQKAALQDFSTEDSK 260

  Fly   255 -----STSNKI--EGYLFKKKSKGFKTWCRRWFYLSDNQLVYRKRSNEDSFSVMEEDLRICSVRP 312
                 .|.|.|  ||||||:.|..||||.||||.:.::||||:||. .|:.:|:.||||:|:|:.
Zfish   261 LEYNIDTDNGIAMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQKRF-RDNPTVVVEDLRLCTVKH 324

  Fly   313 VNEGDRRFCFEVISPTKSHILQADSADMLSLWISALQHSIGAAI-QHDSTHHSRPQSTNAPNNSL 376
            ..:.:|||||||:||:||.::||||..:...||.|:|.||.:|. :::....|..:.::|...||
Zfish   325 CEDVERRFCFEVLSPSKSCMMQADSEKLRQAWIKAVQSSIASAYRENEDEIISLDRQSSASLGSL 389

  Fly   377 PA--------KRRIHWEEFLKIPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKV 433
            .:        |.....:..|.||||.:||||...:||||||||.|||||||||:|||||||.|||
Zfish   390 DSGCESVKLVKGESALQRVLAIPGNEFCCDCGQSDPRWASINLCITLCIECSGIHRSLGVHNSKV 454

  Fly   434 RSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKP---TEQCEIGVREAWIKAKYVERR 495
            ||||||.||.|.:|:|.||||:|:|:||||. .::.|.|||   ..:.||   ||:|:||||::|
Zfish   455 RSLTLDTWEPELLKLMCELGNDVINQIYEAH-REENGGKKPQPGDPRREI---EAFIRAKYVDKR 515

  Fly   496 FVCGMPKPQELLASETAEVLSIDSGGVVEDGESGGS----------GIAKRATLSLGGTRKWAVK 550
            ||.   ||.|  ..:..:::::..    .|....|:          ...|..|.|.......:.:
Zfish   516 FVL---KPTE--QEQMEKIMTLRK----HDKRMQGNMEFLPPRPPPPTPKLRTASNASVASLSGQ 571

  Fly   551 KLRRRQKQRSIPKTLSDDPSIYNT---------AKTGDELEDDDDDESINIPSMSLSISRDDLLV 606
            ::||  .....|..|....|.::|         |.:|.:...|...|.:.....|.|:|..||
Zfish   572 EVRR--DSLFCPDELDSLFSYFDTSSKLQNLKRADSGIQNSADGSREMLASTPSSSSLSETDL-- 632

  Fly   607 IGDDLALDRLETPGILGSDQESTDGESDAESPEELP-FSQL---DANQLLYMASVVHNLPVMCMA 667
                                  .:.|:.|...|..| ||:|   .|:.|||.||...:|..|..|
Zfish   633 ----------------------PESEAAANQAERSPVFSKLTNFSADSLLYWASCACSLKDMAQA 675

  Fly   668 FALGADKMWKNPQDRQRSFLHQAVISGSVMACEFLLLNGAAIDAVDEMGYSALHISTAKGHIAQV 732
            .|.|||..|.|.:|..|:.|.|||..||:::|||||.|.|.:|..|..|...||.:|..||..||
Zfish   676 LAHGADINWVNLEDSSRTPLIQAVQGGSLISCEFLLQNAACVDQQDIRGRGPLHHATILGHTGQV 740

  Fly   733 YLLLKHKAAYDLSSSDGKKALDIAVDQENADIVTLLRLTQLNDEIGPNDEYNGE----------- 786
            .|.||..|..:...:|.:..|.|||:..||||||||||.::|:|:..::...|:
Zfish   741 CLFLKRGAKQNTVDTDSRSPLSIAVEAANADIVTLLRLAKMNEEMRGSEGAFGQAGQYSLSQSHT 805

  Fly   787 DETYKNVMKDFSKL 800
            ::.||..:::|..|
Zfish   806 EQQYKKCIQEFISL 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	73/198 (37%)
		PH	259..352	CDD:278594	49/94 (52%)
		PH_ACAP	260..355	CDD:270070	51/96 (53%)
		ArfGap	384..497	CDD:279720	71/115 (62%)
		ANK	652..768	CDD:238125	53/115 (46%)
		Ank_4	683..736	CDD:290365	25/52 (48%)
		ANK repeat	687..713	CDD:293786	14/25 (56%)
		ANK repeat	715..746	CDD:293786	12/30 (40%)
acap2a	XP_005163306.1	BAR_ACAP2	18..217	CDD:153322	73/198 (37%)
		PH_ACAP	273..369	CDD:270070	51/96 (53%)
		PH	273..365	CDD:278594	49/92 (53%)
		ArfGap	402..520	CDD:279720	73/124 (59%)
		ANK repeat	657..686	CDD:293786	13/28 (46%)
		ANK	658..776	CDD:238125	54/117 (46%)
		Ank_2	660..754	CDD:289560	42/93 (45%)
		ANK repeat	690..721	CDD:293786	15/30 (50%)
		ANK repeat	723..754	CDD:293786	12/30 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	180	1.000	Domainoid score	I3448
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	539	1.000	Inparanoid score	I1149
OMA	1	1.010	-	-		QHG55583
OrthoDB	1	1.010	-	-		D124295at33208
OrthoFinder	1	1.000	-	-		FOG0000653
OrthoInspector	1	1.000	-	-		otm24348
orthoMCL	1	0.900	-	-		OOG6_101039
Panther	1	1.100	-	-	O	PTHR23180
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X412
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.880