DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenB1A and zgc:92360

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001002715.1	Gene:	zgc:92360 / 436988	ZFINID:	ZDB-GENE-040718-470	Length:	377	Species:	Danio rerio

Alignment Length:	323	Identity:	86/323 - (26%)
Similarity:	139/323 - (43%)	Gaps:	73/323 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   373 NNSLPAKRRIHWEEFLKIPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLT 437
            :|...|:...|   .|:.|||..|.||.:..|.|.|.:||:.:|:.|||||||:.. ..||:||.
Zfish     3 DNERAARNLKH---VLQKPGNGSCADCGADNPEWGSCSLGVFICLACSGVHRSIPT-IGKVKSLR 63

  Fly   438 LDAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQ-CEIGVREAWIKAKYVERRFVCGMP 501
            |..||...|:.:.|.||:::..:|||.:  .....|||.: |:: ::|.||:|||..:.|
Zfish    64 LSRWEDSEVQFLSECGNDLMKAVYEAAV--PVYYYKPTHRDCQV-LKEQWIRAKYERQEF----- 120

  Fly   502 KPQELLASETAEVLSID----SGGVVEDGESGGSGIAKRATLSL-GGTRKWAVKKLRRRQKQRSI 561
                   :|..:.|:.:    .|.:::.|...|..:.:|..||: .|..|:..|...:..|....
Zfish   121 -------TEVGKKLTYEDESRDGMLMKRGRDNGQFLNRRFVLSVREGILKYYTKLDAKEPKALMK 178

  Fly   562 PKTLSDDPSIYNTAKTGDELEDDDDDESINIPSMSLSISRDDLLVIGDDLALDRLETPGILGSDQ 626
            ..||:   :.:...|.|       :...:.|..:..:|:| ::.|..|              |.:
Zfish   179 VDTLN---ACFQPDKIG-------NPNGLQITYIKDNITR-NIFVYHD--------------SSK 218

  Fly   627 ESTDGESDAESPEELPFSQLDANQLLYMASVVHNLPVMCMAFALGADKMWKNPQDRQRSFLHQ 689
            |..|.           |:.:.|.||.|:.          :||. ||......|: ..||||.:
Zfish   219 EIVDW-----------FNSIRAAQLHYLK----------VAFP-GATDAELKPK-LTRSFLKE 258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287
		PH	259..352	CDD:278594
		PH_ACAP	260..355	CDD:270070
		ArfGap	384..497	CDD:279720	44/113 (39%)
		ANK	652..768	CDD:238125	10/38 (26%)
		Ank_4	683..736	CDD:290365	4/7 (57%)
		ANK repeat	687..713	CDD:293786	1/3 (33%)
		ANK repeat	715..746	CDD:293786
zgc:92360	NP_001002715.1	ArfGap	8..124	CDD:279720	48/134 (36%)
		PH1_ADAP	132..240	CDD:270072	28/153 (18%)
		PH	134..230	CDD:278594	23/131 (18%)
		PH2_ADAP	254..359	CDD:241282	3/5 (60%)
		PH	257..358	CDD:278594	0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810