DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenB1A and arfgap3

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_991160.1	Gene:	arfgap3 / 402889	ZFINID:	ZDB-GENE-040426-1	Length:	498	Species:	Danio rerio

Alignment Length:	403	Identity:	84/403 - (20%)
Similarity:	135/403 - (33%)	Gaps:	111/403 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 NAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLDA-WESENVKVMMELGNEV 456
            |..|.||.:..|.||||..|:.|||:|||.|||||||.|.:||..||: |....::.|...||..
Zfish    22 NKVCFDCSAKNPSWASITYGVFLCIDCSGTHRSLGVHLSFIRSTELDSNWSWFQLRCMQVGGNAS 86

  Fly   457 VNRIY----------------------------------------------EARIGDDCGLKK-- 473
            .|..:                                              :|.:.....|.|
Zfish    87 ANAFFSQHGCSSSSAANAKYSSRAAALYRDKIRALANQATRQHGTELWLDAQAPLSPSSPLDKQE 151

  Fly   474 ------------PTEQCEIGVREAWIKAKYVERRFVCGMPKPQELLAS---ETAEVLSIDSGGVV 523
                        .|.|..|...:..::......:...| |..::|..|   ..||.||:......
Zfish   152 DFFTQHTQSALPDTVQLNISQSQKRVQDNNNNAKSEAG-PSVEQLSVSPVQSAAEPLSLLKKKPA 215

  Fly   524 EDGESGGSGIAKRATLSLGGTRKWAVKKLRRRQKQRSIPKTLSD-------DPSIYNTAKTGDEL 581
            ...:|.|.|  :||.|   |.:|.:.:....:|::......|::       |.|:::.::....:
Zfish   216 AVRKSAGGG--RRAGL---GAQKVSSQSFTLQQRRAQAEDRLTEQRTSTAPDHSVWSVSRVQQAV 275

  Fly   582 E-------------DDDDDESINI-----PSMSLSISRDDLLVIGDDLALDRLETPGILGSDQES 628
            :             ....:|.:.:     ..:|.|::.|...:|..|  ...|.:..:...|::.
Zfish   276 DVQRSAQDSSSSRMKQQQEERLGMGLSGRSGLSHSVTEDMQTIIQQD--CPSLSSRRVYEEDEQQ 338

  Fly   629 TDGE------SDAESPEELPFSQLDANQLLYMASVVHNLPVMCMAFALGADKMWKNPQ----DRQ 683
            .|..      .:.....:|.|||..:.:...|.....    .|:.....|....|.||    |.|
Zfish   339 EDTHFCSRALDEGRGSSDLFFSQWSSEKQSRMKPESD----YCVEDEHRASASRKEPQSVCDDAQ 399

  Fly   684 RSFLHQAVISGSV 696
            |.|.....||..:
Zfish   400 RKFGDAKAISSDM 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287
		PH	259..352	CDD:278594
		PH_ACAP	260..355	CDD:270070
		ArfGap	384..497	CDD:279720	39/164 (24%)
		ANK	652..768	CDD:238125	12/49 (24%)
		Ank_4	683..736	CDD:290365	5/14 (36%)
		ANK repeat	687..713	CDD:293786	2/10 (20%)
		ANK repeat	715..746	CDD:293786
arfgap3	NP_991160.1	ArfGap	10..123	CDD:279720	33/100 (33%)
arfgap3	NP_991160.1	PLN03114	11..486	CDD:178661	84/403 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900