DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenB1A and Agfg1

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001129068.1	Gene:	Agfg1 / 363266	RGDID:	1560041	Length:	561	Species:	Rattus norvegicus

Alignment Length:	197	Identity:	47/197 - (23%)
Similarity:	85/197 - (43%)	Gaps:	44/197 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   378 AKRRIHWEEFLK-------IPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKVRS 435
            |||: ..|:.||       :|.|..|.||....|.:.::.:|..:|..|||..|.|...: :|:|
  Rat     5 AKRK-QEEKHLKMLRDMTGLPHNRKCFDCDQRGPTYVNMTVGSFVCTSCSGSLRGLNPPH-RVKS 67

  Fly   436 LTLDAWESENVKVMMELGNEVVNRIYEARIG--DDCGLKKPTEQCEIGVREAWIKAKYVERRF-- 496
            :::..:..:.::.:.:.||||..:|:   :|  ||.....|..:....|:| :::.||.::|:
  Rat    68 ISMTTFTQQEIEFLQKHGNEVCKQIW---LGLFDDRSSAIPDFRDPQKVKE-FLQEKYEKKRWYV 128

  Fly   497 --------------VCGMP----------KPQELLASETAEVLSIDSGGVVED---GESGGSGIA 534
                          :.|..          ||.:.|..|:|..|.::.|...:.   |.|.|....
  Rat   129 PPEQAKVVASVHASISGSSASSTSSTPEVKPLKSLLGESAPALHLNKGTPTQSPVVGRSQGQQQE 193

  Fly   535 KR 536
            |:
  Rat   194 KK 195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287
		PH	259..352	CDD:278594
		PH_ACAP	260..355	CDD:270070
		ArfGap	384..497	CDD:279720	32/137 (23%)
		ANK	652..768	CDD:238125
		Ank_4	683..736	CDD:290365
		ANK repeat	687..713	CDD:293786
		ANK repeat	715..746	CDD:293786
Agfg1	NP_001129068.1	COG5347	8..309	CDD:227651	44/194 (23%)
		ArfGap	14..135	CDD:214518	31/125 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..193		5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	409..451
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900