DRSC/TRiP Functional Genomics Resources

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Protein Alignment CenB1A and Appl2

DIOPT Version :9

Sequence 1:NP_524458.1 Gene:CenB1A / 42735 FlyBaseID:FBgn0039056 Length:828 Species:Drosophila melanogaster
Sequence 2:NP_001102211.1 Gene:Appl2 / 362860 RGDID:1563028 Length:662 Species:Rattus norvegicus


Alignment Length:386 Identity:86/386 - (22%)
Similarity:163/386 - (42%) Gaps:66/386 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 EECLKDSPRFRQFVSKEESD----IEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWDLQQ 68
            ||.|:|||:.|..:|..|.|    .::..|.|:.:.::...           |:...::...|.:
  Rat    10 EEALQDSPQTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGA-----------QNEMCLATQQLSR 63

  Fly    69 HFLDNKNAHNALGK-------LIHCF----QEMNKFHTILLDQASRTVLKNLSVFVKDDINQVKD 122
            ..|..:..:.||||       .:|.|    .|:|..|:.|..|.:.|::..:..|.:.|:.:|..
  Rat    64 QLLAYEKQNFALGKGDEEVISTLHYFSKVMDELNGLHSELAKQLADTMVLPVIQFREKDLTEVST 128

  Fly   123 YKGHFLKVSEGYDNALIKNAQASKNRPQEMQE---AANILSASKSCFQH-TALDYVNYITLAQAR 183
            .|..|...|..:|.::.|.::..|.:..|..:   |..:.:|.:.  || ::|.|...:...|.|
  Rat   129 LKDLFGLASNEHDLSMAKYSRLPKRKENERVKTDVAKEVAAARRK--QHLSSLQYYCALNALQYR 191

  Fly   184 KVPSILSTLLDYYQACVTYYHQGFDL-CNDFDEFFKNISE-----------DLNALRGDYQQLEK 236
            |..:::..|:.:....:.::.:|.:: ....|.|..::::           :.:.:|...|:|..
  Rat   192 KRAAMMEPLIGFAHGQINFFKKGAEMFSKSMDGFLSSVTDMVQSIQVELEAEADKMRVSQQELLS 256

  Fly   237 AMQNRHM--------SVNRYCDSNTNSTSNKIEGYLFKKKSKGF--KTWCRRWFYLSDNQLVYRK 291
            ..::.:.        .:||.....|        |||..:...|.  .||.|.:|:.....|:.:.
  Rat   257 VSESVYTPDIDVATPQINRNLIQKT--------GYLNLRNKTGLVTTTWERLYFFTQGGNLMCQP 313

  Fly   292 RSNEDSFSVMEEDLRICSVRPVNEGDRRFCFEVISPT--KSHILQADSADMLSLWISALQH 350
            |.......:  :||..|||..|:..|||:||::.:|:  ...||||:|......||.|:.:
  Rat   314 RGAVAGGLI--QDLDNCSVMAVDCEDRRYCFQISTPSGKPGIILQAESRKEYEEWICAINN 372

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CenB1ANP_524458.1 BAR_ACAPs 18..217 CDD:153287 43/218 (20%)
PH 259..352 CDD:278594 30/96 (31%)
PH_ACAP 260..355 CDD:270070 30/95 (32%)
ArfGap 384..497 CDD:279720
ANK 652..768 CDD:238125
Ank_4 683..736 CDD:290365
ANK repeat 687..713 CDD:293786
ANK repeat 715..746 CDD:293786
Appl2NP_001102211.1 BAR_APPL2 20..234 CDD:153316 44/226 (19%)
BAR-PH_APPL 252..376 CDD:270067 35/131 (27%)
PTB_APPL 480..613 CDD:269980
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 643..662
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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