DRSC/TRiP Functional Genomics Resources

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Protein Alignment CenB1A and Appl2

DIOPT Version :10

Sequence 1:NP_524458.1 Gene:CenB1A / 42735 FlyBaseID:FBgn0039056 Length:828 Species:Drosophila melanogaster
Sequence 2:NP_001102211.1 Gene:Appl2 / 362860 RGDID:1563028 Length:662 Species:Rattus norvegicus


Alignment Length:386 Identity:86/386 - (22%)
Similarity:163/386 - (42%) Gaps:66/386 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 EECLKDSPRFRQFVSKEESD----IEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWDLQQ 68
            ||.|:|||:.|..:|..|.|    .::..|.|:.:.::...           |:...::...|.:
  Rat    10 EEALQDSPQTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGA-----------QNEMCLATQQLSR 63

  Fly    69 HFLDNKNAHNALGK-------LIHCF----QEMNKFHTILLDQASRTVLKNLSVFVKDDINQVKD 122
            ..|..:..:.||||       .:|.|    .|:|..|:.|..|.:.|::..:..|.:.|:.:|..
  Rat    64 QLLAYEKQNFALGKGDEEVISTLHYFSKVMDELNGLHSELAKQLADTMVLPVIQFREKDLTEVST 128

  Fly   123 YKGHFLKVSEGYDNALIKNAQASKNRPQEMQE---AANILSASKSCFQH-TALDYVNYITLAQAR 183
            .|..|...|..:|.::.|.::..|.:..|..:   |..:.:|.:.  || ::|.|...:...|.|
  Rat   129 LKDLFGLASNEHDLSMAKYSRLPKRKENERVKTDVAKEVAAARRK--QHLSSLQYYCALNALQYR 191

  Fly   184 KVPSILSTLLDYYQACVTYYHQGFDL-CNDFDEFFKNISE-----------DLNALRGDYQQLEK 236
            |..:::..|:.:....:.::.:|.:: ....|.|..::::           :.:.:|...|:|..
  Rat   192 KRAAMMEPLIGFAHGQINFFKKGAEMFSKSMDGFLSSVTDMVQSIQVELEAEADKMRVSQQELLS 256

  Fly   237 AMQNRHM--------SVNRYCDSNTNSTSNKIEGYLFKKKSKGF--KTWCRRWFYLSDNQLVYRK 291
            ..::.:.        .:||.....|        |||..:...|.  .||.|.:|:.....|:.:.
  Rat   257 VSESVYTPDIDVATPQINRNLIQKT--------GYLNLRNKTGLVTTTWERLYFFTQGGNLMCQP 313

  Fly   292 RSNEDSFSVMEEDLRICSVRPVNEGDRRFCFEVISPT--KSHILQADSADMLSLWISALQH 350
            |.......:  :||..|||..|:..|||:||::.:|:  ...||||:|......||.|:.:
  Rat   314 RGAVAGGLI--QDLDNCSVMAVDCEDRRYCFQISTPSGKPGIILQAESRKEYEEWICAINN 372

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CenB1ANP_524458.1 BAR_ACAPs 18..217 CDD:153287 43/218 (20%)
PH_ACAP 260..355 CDD:270070 30/95 (32%)
ArfGap_ACAP 381..497 CDD:350064
ANKYR <647..>768 CDD:440430
ANK repeat 687..713 CDD:293786
ANK repeat 715..746 CDD:293786
Appl2NP_001102211.1 BAR_APPL2 20..234 CDD:153316 44/226 (19%)
BAR-PH_APPL 252..376 CDD:270067 35/131 (27%)
PTB_APPL 480..613 CDD:269980
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 643..662
Blue background indicates that the domain is not in the aligned region.

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