DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenB1A and Asap2

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_038969071.1	Gene:	Asap2 / 362719	RGDID:	1305263	Length:	1003	Species:	Rattus norvegicus

Alignment Length:	795	Identity:	170/795 - (21%)
Similarity:	289/795 - (36%)	Gaps:	232/795 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 KEESDIEHLE-QRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWDLQQHFL--DNKNAHNALGKLI 84
            :|..|::.:. .:::|.:|..|:   ||..:|:|:..:..:|.....:.:  |:.:..:|..|..
  Rat    41 EEALDVDRMVLYKMKKSVKAINI---SGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFS 102

  Fly    85 HCFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVK-DYKGHFLKVSEGYDNALIKNAQASKNR 148
            ...:|:......|:...:..:...|...:|.|:..|| |.|..|.|..:.|:..:.|..:..|..
  Rat   103 VFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEH 167

  Fly   149 PQ-------EMQ--EAANILSASKSCFQHTALDYVNYITLAQARKVPSILSTLLDYYQACVTYYH 204
            .:       |:.  |.|..:...:..||....:|:..:...:.:|...:|..|:.|:.|...::.
  Rat   168 AKLHGMIRTEISGAEIAEEMEKERRFFQLQMCEYLLKVNEIKVKKGVDLLQNLIKYFHAQCNFFQ 232

  Fly   205 QGFDLCNDFDEFFKNISEDLNALRGDYQQ-----------LEKAMQNRHMSVNRYCDSNTNSTS- 257
            .|...........:.:|.||:.::....:           |:.|:|.......|  ||....::
  Rat   233 DGLKAVESLKPSIETLSTDLHTIKQAQDEERRQLIQLRDILKSALQVEQKESRR--DSQLRQSTA 295

  Fly   258 --------NK-----IEGYLFKKKSKGFKTWCRRWFYLSDNQLVYRKRSNEDSFSVMEE------ 303
                    ||     ..|.|:||.....|.|.:            ||.|.::.|..:..
  Rat   296 YSLHQPQGNKEHGTERNGNLYKKSDGIRKVWQK------------RKCSVKNGFLTISHGTANRP 348

  Fly   304 ----DLRICSVRPVNEGDRRFCFEVISPTKSHILQADSADMLSLWISALQHSIGAAIQH-----D 359
                :|..|.|: .|..::: ||::||..:::..||:......:|:|.||:|...|:.:     |
  Rat   349 PAKLNLLTCQVK-TNPEEKK-CFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDD 411

  Fly   360 STHHSRPQSTNAPNNSLPAKRRIHWEEFLKIPGNAYCCDCRSPEPRWASINLGITLCIECSGVHR 424
            :|         ..||.:....:....|..::.||..||||.:|:|.|.|.||||..||||||:||
  Rat   412 NT---------GENNIVQELTKEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHR 467

  Fly   425 SLGVHYSKVRSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLK-----KPTEQCEIGVRE 484
            .||||||:::|||||...:..:.:...:||...|.|.|      |.|.     ||....::..|:
  Rat   468 ELGVHYSRMQSLTLDVLGTSELLLAKNIGNAGFNEIME------CCLPPEDPVKPNPGSDMIARK 526

  Fly   485 AWIKAKYVERRFVCGMPKPQELLASETAEVLSIDSGGVVEDGESGGSGIAKRATLSLGGTRKWAV 549
            .:|.|||:|||:.
  Rat   527 DYITAKYMERRYA---------------------------------------------------- 539

  Fly   550 KKLRRRQKQRSIPKTLSDDPSIYNTAKTGDELEDDDDDESINIPSMSLSISRDDLLVIGDDLALD 614
               ||:...     |.:...|:....||.|
  Rat   540 ---RRKHAD-----TAAKLHSLCEAVKTRD----------------------------------- 561

  Fly   615 RLETPGILGSDQESTDGESDAESPEELPFSQLDANQLLYMASVVHNLPVMCMAFALGADKMWKNP 679
                  |.|..|...||   .:..|::|.:                                 |.
  Rat   562 ------IFGLLQAYADG---VDLTEKIPLA---------------------------------NG 584

  Fly   680 QDRQRSFLHQAVIS---GSVMACEFLLLNGAAIDAVDEMGYSALHISTAKGHIAQVYLLLKHKAA 741
            .:...:.||.||.|   .|:...:||:.|...:|.....|.:|||......:...:.|||:.||:
  Rat   585 HEPDETALHLAVRSVDRTSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKAS 649

  Fly   742 YDLSSSDGKKALDIA 756
            .::::..|:..||||
  Rat   650 IEIANESGETPLDIA 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	39/206 (19%)
		PH	259..352	CDD:278594	25/107 (23%)
		PH_ACAP	260..355	CDD:270070	25/104 (24%)
		ArfGap	384..497	CDD:279720	51/117 (44%)
		ANK	652..768	CDD:238125	25/108 (23%)
		Ank_4	683..736	CDD:290365	15/55 (27%)
		ANK repeat	687..713	CDD:293786	10/28 (36%)
		ANK repeat	715..746	CDD:293786	9/30 (30%)
Asap2	XP_038969071.1	BAR_ASAP2	34..248	CDD:153326	39/209 (19%)
		PH_ASAP	300..406	CDD:270071	28/119 (24%)
		ArfGap_ASAP2	422..544	CDD:350074	53/182 (29%)
		ANK repeat	553..585	CDD:293786	11/108 (10%)
		ANK repeat	589..621	CDD:293786	10/31 (32%)
		Ank_2	592..678	CDD:403870	24/73 (33%)
		ANK repeat	623..654	CDD:293786	9/30 (30%)
		SH3_ASAP2	945..1000	CDD:212899
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920