DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenB1A and Agap3

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_006236000.1	Gene:	Agap3 / 362300	RGDID:	1310751	Length:	1093	Species:	Rattus norvegicus

Alignment Length:	239	Identity:	80/239 - (33%)
Similarity:	121/239 - (50%)	Gaps:	31/239 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   315 EGDRRFCFEVISPT-KSHILQADSADMLSLWISALQHSIGAAIQ-----HDSTHHSRPQSTNAPN 373
            |.:..|.|.|:|.| ::...:|.:|:...||:.::|..|.|::|     .|.|.... |||....
  Rat   784 ETEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGN-QSTALAV 847

  Fly   374 NSLPAKRRIHWEEFLKIPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTL 438
            .::...|           ||::|.||.:|.|.|||:|||..:||||||:||.||.|.|:||||.|
  Rat   848 QTVRTAR-----------GNSFCVDCEAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDL 901

  Fly   439 DAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEIGVREAWIKAKYVERRFVCGMPKP 503
            |.|..|.:.||..:||.:.|.::|..:.   |..||..:.....:|.||:|||.::.|:..:|..
  Rat   902 DDWPPELLAVMTAMGNALANSVWEGALD---GYSKPGPEACREEKERWIRAKYEQKLFLAPLPSS 963

  Fly   504 -----QELLASETAE-----VLSIDSGGVVEDGESGGSGIAKRA 537
                 |:||.:...:     |:.:..|...|..|:.|.|..:.|
  Rat   964 DVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTA 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287
		PH	259..352	CDD:278594	11/37 (30%)
		PH_ACAP	260..355	CDD:270070	12/40 (30%)
		ArfGap	384..497	CDD:279720	48/112 (43%)
		ANK	652..768	CDD:238125
		Ank_4	683..736	CDD:290365
		ANK repeat	687..713	CDD:293786
		ANK repeat	715..746	CDD:293786
Agap3	XP_006236000.1	small_GTPase	309..474	CDD:197466
		Centaurin_gamma	311..468	CDD:133303
		PH_AGAP	584..827	CDD:241281	13/42 (31%)
		PH	587..>648	CDD:278594
		ArfGap	855..960	CDD:279720	49/107 (46%)
		Ank_2	971..1061	CDD:289560	9/37 (24%)
		ANK	971..>1060	CDD:238125	9/37 (24%)
		ANK repeat	971..1001	CDD:293786	6/29 (21%)
		ANK repeat	1003..1034	CDD:293786	1/5 (20%)
		ANK repeat	1036..1061	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820