DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenB1A and Asap

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001014504.1	Gene:	Asap / 35783	FlyBaseID:	FBgn0050372	Length:	1155	Species:	Drosophila melanogaster

Alignment Length:	933	Identity:	212/933 - (22%)
Similarity:	338/933 - (36%)	Gaps:	298/933 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ATIEF-EECLKD--SPRFRQFVSKEESDIEH----LEQRLE-------KIIKLCNVAVDSGKEYV 53
            |..|| ||...|  ||....|.|: ..|..|    ||:|||       |:.|......:||..:|
  Fly     7 AVSEFVEETRSDYSSPTTSTFASR-MPDCRHTIGVLEERLEFDREGLTKLKKAVKAIHNSGNTHV 70

  Fly    54 KNQSAFAMSLWDLQQHFL--DNKNAHNALGKLIHCFQEMNKFHTILLDQASRTVLKNLSVFVKDD 116
            .|:.....:|..|....:  |..:...|..|.....:|::.....|:...:..|:..:...:|.:
  Fly    71 DNEMFMVRALERLGGKVIEQDEPDIGAAFLKFSVVTKELSALMKTLMQNINNIVMFPVDSMLKSE 135

  Fly   117 INQVK-DYKGHFLKVSEGYDNALIKNAQASKNRPQEMQEA------------ANILSASKSCFQH 168
            :..|| |.|..|.|.::.|:...||   ..|.:..:.:||            |..:...:..:|.
  Fly   136 LRGVKGDMKRPFDKAAKDYEAKFIK---IEKEKKAQAKEAGMVRTEIDAAVVAEEMEKERRLYQL 197

  Fly   169 TALDYVNYITLAQARKVPSILSTLLDYYQACVTYYHQGFDLCNDFDEFFKNISEDLNALR----- 228
            ...:|:......:.:....:|..|::||.|...|:..|......|..:..::||.|:.::
  Fly   198 QTCEYLLKYKDIKTKTGIELLQHLIEYYHALSNYFKDGLQTIEHFGTYIGDLSEKLHEIKQKQDE 262

  Fly   229 ---------------GDYQQ-----------------LEKAMQNRHMSVNRYCDSNTNSTSNKIE 261
                           .|:::                 |.:...::|..|.|             :
  Fly   263 DRRSLLDLRTVLRSTPDFERVDNVPSSESRSGGAGYSLHQLQGDKHHGVTR-------------Q 314

  Fly   262 GYLFKK-KSKGFKTWCRRWFYLSDNQLVYRKRSNEDSF-SVMEED---------LRICSVRPVNE 315
            |:|.|| :.|..:.|.:|           |.|...|.| .:...|         |..|.::||.:
  Fly   315 GHLLKKSEGKVRRVWQKR-----------RCRVTSDGFLDIFHADESKPPTRVNLLTCQIKPVPD 368

  Fly   316 GDRRFCFEVISPTKSHILQADSADMLSLWISAL----QHSIGAAIQHDSTHHSRPQSTNAPNNSL 376
            ..|.  |::||..:.:..||:.......|::.|    :.::..|.|     |:.||.  :|:...
  Fly   369 DKRG--FDLISYNRPYHFQAEDEGDQKAWMAVLVNCKEKALTKAFQ-----HANPQM--SPSLVE 424

  Fly   377 PAKRRIHWEEFLKIPGNAYCCDCRS-PEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLDA 440
            ..|..|.:.:.|  |||..||||.| .:..|.|:|.||.:||:||||||.||||:|:::|||||.
  Fly   425 LQKTVIRYVQLL--PGNDRCCDCGSRNDVTWISLNFGILVCIQCSGVHRDLGVHHSRIQSLTLDN 487

  Fly   441 WESENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEIGVREAWIKAKYVERRFVCGMPKPQE 505
            ..:.|:.:...:||..:|.|.||::|..    |...:..:..|..:|:||||.:|:|.
  Fly   488 LTTANLLIARAMGNSTLNDIMEAKLGRG----KLQHESSMEERYDFIRAKYVAKRYVM------- 541

  Fly   506 LLASETAEVLSIDSGGVVEDGESGGSGIAKRATLSLGGTRKWAVKKLRRRQKQRSIPKTLSDDPS 570
                                                                     :|.|||
  Fly   542 ---------------------------------------------------------RTCSDD-- 547

  Fly   571 IYNTAKTGDELEDDDDDESINIPSMSLSISRDDLLVIGDDLALDRLETPGILGSDQESTDGESDA 635
                    ::|..|.:...:|
  Fly   548 --------NDLRCDLEQAVVN-------------------------------------------- 560

  Fly   636 ESPEELPFSQLDANQLLYMASVVHNLPVMCMAFALGADKMWKNP-QDRQRSFLHQAVI--SGSVM 697
                      .|.:|||             ..:|.|||.....| .|...:.||.||:  .||.:
  Fly   561 ----------ADMSQLL-------------QVWAEGADLTCCLPSSDAGETALHLAVLREMGSTL 602

  Fly   698 -ACEFLL-------LNGAAIDA--VDEMG-YSALHISTAKGHIAQVYLLLKHKAAYDLSSSDGKK 751
             ..:||:       ||.|...|  :|..| .:|||:.........:.|||:..|.|:|.:|..|.
  Fly   603 HIVDFLIQNMPPKGLNKATNPAGLLDVTGKNTALHLCALHDRRECMKLLLRSGADYELKNSQNKT 667

  Fly   752 ALDIAVDQENADIVTLL-----RLTQLNDEIG-----PNDEYN---GEDETYKNVMKDFSKLPA- 802
            |||||.:..:.....|:     |.....|.|.     ||::.:   .:|||..:..|..|:.|:
  Fly   668 ALDIAKEMGHNSCRELIECAIKREKSAFDHINTDWNLPNEDGSTDFSDDETVIDERKSRSRPPSF 732

  Fly   803 --SQTRVLRQRHDSNTLESQRSS 823
              ..:.|||.|  |:|.:|.:||
  Fly   733 AGGDSPVLRSR--SSTCDSIQSS 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	47/224 (21%)
		PH	259..352	CDD:278594	24/107 (22%)
		PH_ACAP	260..355	CDD:270070	24/109 (22%)
		ArfGap	384..497	CDD:279720	48/113 (42%)
		ANK	652..768	CDD:238125	37/129 (29%)
		Ank_4	683..736	CDD:290365	18/65 (28%)
		ANK repeat	687..713	CDD:293786	12/37 (32%)
		ANK repeat	715..746	CDD:293786	10/31 (32%)
Asap	NP_001014504.1	BAR_ASAPs	35..249	CDD:153288	44/216 (20%)
		PH_ASAP	302..410	CDD:270071	27/133 (20%)
		ArfGap_ASAP	425..541	CDD:350063	50/121 (41%)
		Ank_2	554..662	CDD:403870	34/174 (20%)
		ANK repeat	586..622	CDD:293786	11/35 (31%)
		ANK repeat	624..662	CDD:293786	12/37 (32%)
		Ank_2	636..>693	CDD:403870	17/56 (30%)
		SH3_ASAP	1095..1149	CDD:212755
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464117
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46810
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.750