DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenB1A and drongo

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001162848.1	Gene:	drongo / 33263	FlyBaseID:	FBgn0020304	Length:	673	Species:	Drosophila melanogaster

Alignment Length:	435	Identity:	78/435 - (17%)
Similarity:	137/435 - (31%)	Gaps:	138/435 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 NAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLDAWESENVKVMMELGNEVV 457
            |..|.||....|.:.::.:|..:|..||||.|.|...: :|:|:::..:..:.:..:...|||:.
  Fly    27 NRQCFDCGQKGPTYVNMTIGSFVCTRCSGVLRGLTPPH-RVKSISMATFTQDEIDFLRSHGNELC 90

  Fly   458 NRIYEARIGDDCGLKKPTEQCEIGVREAWIKAKYVERRFVCGMPKPQELLASETAEVLSIDSGGV 522
            .:.:       .||..|........:...:..||..:|:......|.:.||:......|..:...
  Fly    91 AKTW-------LGLWDPKRAVHQQEQRELMMDKYERKRYYLEPASPLKSLANAVNLKSSAPATNH 148

  Fly   523 VEDGESGGSGIAKRATLSLGGTRKWAVKKLRRRQKQRSIPKTLSDDPSIYNTAKTGDELEDDDDD 587
            .::|...|     .|::.|                         ..|:...|:..|  |:...:.
  Fly   149 TQNGHQNG-----YASIHL-------------------------TPPAAQRTSANG--LQKVANS 181

  Fly   588 ESINIPSMSLSISR-------------DDLLVIGDDLALDRLETPGILGSDQESTDGESDAESPE 639
            .|.:....|.||||             .|...:|.  .|..|.:.|     ..||...||..|
  Fly   182 SSNSSGKTSSSISRPHYNHQNNSQNNNHDAFGLGG--GLSSLNSAG-----STSTGALSDTSS-- 237

  Fly   640 ELPFSQLDANQLLYMASVVHNLPVMCMAFALGADKMWKNPQDRQRSFLHQAVISGSVMACEFLLL 704
                                     |.:...|||                         |:|:..
  Fly   238 -------------------------CASNGFGAD-------------------------CDFVAD 252

  Fly   705 NGA---------------AIDAVDEM----GYSALHISTAKGHIAQVYLLLKHKAAYDLSSSDGK 750
            .|:               |:.:|..:    ||:.:....| .|:.|...|.:......|.:.:|.
  Fly   253 FGSANIFDATSARSTGSPAVSSVSSVGSSNGYAKVQPIRA-AHLQQQQQLQQQLHQQQLLNGNGH 316

  Fly   751 KALDIAVDQENADIVTLLRLTQLNDEI------GPNDEYNGEDET 789
            :..:...|.::|.|...:.....||.|      |.:|.::..|::
  Fly   317 QGTENFADFDHAPIYNAVAPPTFNDWISDWSRRGFHDPFDDCDDS 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287
		PH	259..352	CDD:278594
		PH_ACAP	260..355	CDD:270070
		ArfGap	384..497	CDD:279720	24/103 (23%)
		ANK	652..768	CDD:238125	20/134 (15%)
		Ank_4	683..736	CDD:290365	10/71 (14%)
		ANK repeat	687..713	CDD:293786	4/40 (10%)
		ANK repeat	715..746	CDD:293786	7/34 (21%)
drongo	NP_001162848.1	ArfGap	15..126	CDD:279720	24/106 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464115
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740