DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenB1A and AGFG1

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001128659.1	Gene:	AGFG1 / 3267	HGNCID:	5175	Length:	584	Species:	Homo sapiens

Alignment Length:	263	Identity:	62/263 - (23%)
Similarity:	105/263 - (39%)	Gaps:	77/263 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   378 AKRRIHWEEFLK-------IPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKVRS 435
            |||: ..|:.||       :|.|..|.||....|.:.::.:|..:|..|||..|.|...: :|:|
Human     5 AKRK-QEEKHLKMLRDMTGLPHNRKCFDCDQRGPTYVNMTVGSFVCTSCSGSLRGLNPPH-RVKS 67

  Fly   436 LTLDAWESENVKVMMELGNEVVNRIYEARIG--DDCGLKKPTEQCEIGVREAWIKAKYVERRFVC 498
            :::..:..:.::.:.:.||||..:|:   :|  ||.....|..:....|:| :::.||.::|:..
Human    68 ISMTTFTQQEIEFLQKHGNEVCKQIW---LGLFDDRSSAIPDFRDPQKVKE-FLQEKYEKKRWYV 128

  Fly   499 GMPKPQELLASETAEVLSIDSGGVVEDGESGGSGIAKRATLSLGGTRKWAVKKLRRRQKQRSIPK 563
             .|:..:::||..|.:             ||.|..:..:|..        ||.|          |
Human   129 -PPEQAKVVASVHASI-------------SGSSASSTSSTPE--------VKPL----------K 161

  Fly   564 TLSDD--PSIYNTAKTGDELEDDDDDESINIPSMSLSISRD----------DLLVIGDDLALDRL 616
            :|..|  |:::....|               ||.|..:.|.          |||   .||..|..
Human   162 SLLGDSAPTLHLNKGT---------------PSQSPVVGRSQGQQQEKKQFDLL---SDLGSDIF 208

  Fly   617 ETP 619
            ..|
Human   209 AAP 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287
		PH	259..352	CDD:278594
		PH_ACAP	260..355	CDD:270070
		ArfGap	384..497	CDD:279720	32/121 (26%)
		ANK	652..768	CDD:238125
		Ank_4	683..736	CDD:290365
		ANK repeat	687..713	CDD:293786
		ANK repeat	715..746	CDD:293786
AGFG1	NP_001128659.1	COG5347	8..319	CDD:227651	59/260 (23%)
AGFG1	NP_001128659.1	ArfGap	14..135	CDD:214518	32/126 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810