Protein Alignment CenB1A and agap3

DIOPT Version :10

• Sequence 1: NP_524458.1
• Gene: CenB1A / 42735
• FlyBaseID: FBgn0039056
• Length: 828
• Species: Drosophila melanogaster
• Sequence 2: XP_009295860.1
• Gene: agap3 / 324332
• ZFINID: ZDB-GENE-110927-1
• Length: 1295
• Species: Danio rerio
• Alignment Length: 771
• Identity: 161/771 - (20%)
• Similarity: 257/771 - (33%)
• Gaps: 317/771 - (41%)

  Fly    43 NVAVD--SGKEYVKNQSAFAMSL-WDLQQHFLDNK-----NAHNALGKLIHCF----------QE 89
            :||::  :|..:.|.|.:|..|. |.|.:...:.|     |..:....|:|.:          .|
Zfish   476 SVAIETLAGIGFRKGQDSFVNSQEWTLSRSVPELKVGIVGNLSSGKSALVHRYLTGTYVQEESPE 540

  Fly    90 MNKF-HTILLDQASRTVL---------------KNLSVFV---KDDINQVKDYKGHFLKVSEGYD 135
            ..:| ..|::|..|..:|               .:..|||   :|:|:....| .:||::| .|.
Zfish   541 GGRFKKEIVVDGQSYLLLIRDEGGPPELQFAAWVDAVVFVFSLEDEISFQTVY-NYFLRLS-SYR 603

  Fly   136 NALIKNAQASKNRPQEMQEAANILSASKSCFQHTALDYVNYITLAQARKVPSIL--STLLDYYQA 198
            ||    |:.    |..:....:.:||:..          ..|..|:|||:.:.|  ||   ||:.
Zfish   604 NA----AEV----PMVLVGTQDAISAANP----------RVIDDARARKLSNDLKRST---YYET 647

  Fly   199 CVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQQLE----KAMQN------------------- 240
            |.||   |.::    :..|:::::.:.||| ..|||.    |::.|
Zfish   648 CSTY---GLNV----ERVFQDVAQKVVALR-KKQQLSIGPCKSLPNSPSHSSVPAASIPSVHINQ 704

  Fly   241 -----------------------RHMSVNRYCDSNTNS-------------TSNKI--------- 260
                                   |.|.:.....|||.:             ||.|.
Zfish   705 AANGGGAFSDYSSSVPSTPSISQREMRIETVAASNTPTPIRKQSKRRSNIFTSRKASDQTKSIES 769

  Fly   261 --------------EGYLFKKKSKGF-KTWCRRWFYLSDNQLV--------YRKRSNEDSFSVME 302
                          :|.|.|:..|.. |.|.:::..|.||.|:        |.:..:.....::.
Zfish   770 KTDSIGSGRAIPIKQGILLKRSGKSLNKEWKKKYVTLCDNGLLTYHPSLHDYMQNVHGKEIDLLR 834

  Fly   303 EDLRICSVRPV------------------------------------------------------ 313
            ..:::...||.
Zfish   835 TTVKVPGKRPPRAVATVAPTASPKTNGLTKDRSTLQLGIGATSTPHSNSSSSLQSGGSTAGVALG 899

  Fly   314 --NEGDRRFCFEVIS-------------------------------------PTKSHI------- 332
              .||..:..|.|.|                                     |...|.
Zfish   900 TNKEGMHQRSFSVSSAEQWNEAVISTTSANGVSDPLSSASGMSSATSPKLEPPPSPHANRKKHRR 964

  Fly   333 ------------------------------------LQADSADMLSLWISALQHSIGAAIQHDST 361
                                                .:|.:.:...||:.|::..|.|::|  |.
Zfish   965 KKSTGITKPDSLSAGSEEPEESFEFIIVSLTGQMWHFEASTFEERELWVQAIESQILASLQ--SC 1027

  Fly   362 HHSRPQSTNAPNNSLPAKRRIHWEEFLKIPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSL 426
            ..|:.:|.....:...|.:.|.     .:.||::|.||.:|.|.|||:|||..:||||||:||:|
Zfish  1028 ESSKNKSRLGSQSDALAIQSIR-----NVRGNSFCADCDAPNPDWASLNLGALICIECSGMHRNL 1087

  Fly   427 GVHYSKVRSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEIGVREAWIKAKY 491
            |.|.|:||||.||.|..|...||..:||.:.|.::||.:.   |..||........:|.||:|||
Zfish  1088 GTHLSRVRSLDLDDWPVELSMVMTAIGNAMANSVWEACVD---GYNKPGVDSTREEKERWIRAKY 1149

  Fly   492 VERRFVCGMPKP-----QELLASETAE-----VLSIDSGGVVEDGESGGSGIAKRA 537
            .::.||..:|:.     |:||.:...:     ||.:..|...|..|:.|.|..:.|
Zfish  1150 EQKLFVVALPQSDVPLGQQLLRAVVEDDLRLVVLLLAHGTKEEVNETYGDGDGRTA 1205

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	49/212 (23%)
		PH_ACAP	260..355	CDD:270070	25/262 (10%)
		ArfGap_ACAP	381..497	CDD:350064	50/115 (43%)
		ANKYR	<647..>768	CDD:440430
		ANK repeat	687..713	CDD:293786
		ANK repeat	715..746	CDD:293786
agap3	XP_009295860.1	Centaurin_gamma	509..666	CDD:133303	41/186 (22%)
		PH_AGAP	778..1025	CDD:241281	26/246 (11%)
		ArfGap_AGAP3	1041..1150	CDD:350080	50/116 (43%)
		ANKYR	<1199..>1258	CDD:440430	2/7 (29%)
		ANK repeat	1201..1232	CDD:293786	1/5 (20%)
		ANK repeat	1234..1259	CDD:293786