DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenB1A and Agap1

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_038939665.1	Gene:	Agap1 / 316611	RGDID:	1309244	Length:	1428	Species:	Rattus norvegicus

Alignment Length:	252	Identity:	83/252 - (32%)
Similarity:	130/252 - (51%)	Gaps:	31/252 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   306 RICSVRPV--------NEGDRRFCFEVISPT-KSHILQADSADMLSLWISALQHSIGAAIQHDST 361
            |:.|:|.:        .|.:....|.::|.| ::...:|.:.:....|:.|::..|.|::|  |.
  Rat  1103 RVGSLRNIYSSSSTNTEEQEENLEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQ--SC 1165

  Fly   362 HHSRPQSTNAPNNSLPAKRRIHWEEFLKIPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSL 426
            ..|:.:|.....:...|.:.|.     .:.||::|.||.:..|.|||:|||..:||||||:||:|
  Rat  1166 ESSKNKSRLTSQSEAMALQSIR-----NMRGNSHCVDCDTQNPNWASLNLGALMCIECSGIHRNL 1225

  Fly   427 GVHYSKVRSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEIGVREAWIKAKY 491
            |.|.|:||||.||.|..|.:|||..:|||:.|.::|.  |.. |..||:.......:|.||:|||
  Rat  1226 GTHLSRVRSLDLDDWPMELIKVMSSIGNELANSVWEE--GSQ-GRTKPSLDSTREEKERWIRAKY 1287

  Fly   492 VERRFVCGMP-----KPQELLASETAE------VLSIDSGGVVEDGESGGSGIAKRA 537
            .::.|:..:|     ..|:||.: |||      :|.:..|...|..|:.|.|..:.|
  Rat  1288 EQKLFLAPLPCTEFSLGQQLLHA-TAEEDLRTVILLLAHGSRDEVNETCGEGDGRTA 1343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287
		PH	259..352	CDD:278594	10/54 (19%)
		PH_ACAP	260..355	CDD:270070	11/57 (19%)
		ArfGap	384..497	CDD:279720	50/112 (45%)
		ANK	652..768	CDD:238125
		Ank_4	683..736	CDD:290365
		ANK repeat	687..713	CDD:293786
		ANK repeat	715..746	CDD:293786
Agap1	XP_038939665.1	Centaurin_gamma	561..722	CDD:133303
		PH_AGAP	837..>911	CDD:241281
		PH-like	<1123..1163	CDD:418428	8/39 (21%)
		ArfGap_AGAP2	1180..1288	CDD:350078	51/115 (44%)
		ANK repeat	1304..1332	CDD:293786	9/28 (32%)
		Ank_2	1307..1397	CDD:403870	12/38 (32%)
		ANK repeat	1339..1370	CDD:293786	1/5 (20%)
		ANK repeat	1372..1397	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820