DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenB1A and Acap3

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001382677.1	Gene:	Acap3 / 313772	RGDID:	1310711	Length:	833	Species:	Rattus norvegicus

Alignment Length:	867	Identity:	308/867 - (35%)
Similarity:	470/867 - (54%)	Gaps:	116/867 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TIEFEECLKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWDLQQ 68
            |:|||||:|||||||..:.:.|:|:..:|.:|:|::|||:..:::||.||.....|...:.||.|
  Rat     2 TVEFEECIKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMIEAGKAYVTTNRLFVSGVRDLSQ 66

  Fly    69 HFLDNKNAHNALGKLIHCFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVKDYKGHFLKVSEG 133
            ....:......|.:.....|||..:||||.|||.|:|.:.|..|||:|:.:.|:.|..|.||.|.
  Rat    67 QCQGDTVISECLQRFGDSLQEMVNYHTILFDQAQRSVRQQLHNFVKEDVRKFKETKKQFDKVRED 131

  Fly   134 YDNALIKNAQASKNRPQEMQEAANILSASKSCFQHTALDYVNYITLAQARKVPSILSTLLDYYQA 198
            .:.:|::||||.::||.|::||...|:.::.||:|.|||||..|.:.||:|...||.::|.:..|
  Rat   132 MELSLVRNAQAPRHRPHEVEEATGALTLTRKCFRHLALDYVLQINVLQAKKKFEILDSMLSFMHA 196

  Fly   199 CVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQQLEKAMQNRHMSVNR------------YCDS 251
            ..:::.||:.|.:..|.:.|.::.:|:.|..|....::.|:.:|.::.:            ..:.
  Rat   197 QYSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKREMERKHAAIQQRTLLQDFSYDEPKVEF 261

  Fly   252 NTNSTSNKI-EGYLFKKKSKGFKTWCRRWFYLSDNQLVYRKRSNEDSFSVMEEDLRICSVRPVNE 315
            :.::.|..: ||||||:.|..||||.||||.:.::||||:|:. :|:.:|:.:|||:|||:|..:
  Rat   262 DVDAPSGVVMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQKKL-KDALTVVVDDLRLCSVKPCED 325

  Fly   316 GDRRFCFEVISPTKSHILQADSADMLSLWISALQHSIGAAIQH--DSTHHSRPQSTNAPNNSL-- 376
            .:|||||||:|||||.:|||||..:...|:.|:|.||.:|.:.  ||.:..|...|.:|:.|.
  Rat   326 IERRFCFEVVSPTKSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSID 390

  Fly   377 ----PAKRRIHWEEFLK----IPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKV 433
                ..:|.:..|..|:    :.||:.|.||..|:|||||||||:.|||||||:|||||||.|||
  Rat   391 STTDSRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKV 455

  Fly   434 RSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEIGVREAWIKAKYVERRFVC 498
            ||||||:||.|.:|:|.||||..:|:||||:. :..|::|||.......:|||||.||||::|:
  Rat   456 RSLTLDSWEPELLKLMCELGNNTMNQIYEAQC-EGPGIRKPTASSSRQDKEAWIKDKYVEKKFL- 518

  Fly   499 GMPKPQELLASETAEVLSIDSGGVVEDGESGGSGIAKRATLSLGGTRKWAVKKLRR--------- 554
                 ::|.::...|                             ..|:|..:|.:|
  Rat   519 -----RKLTSAPVRE-----------------------------PPRRWRAQKCQRPHSSPHAPT 549

  Fly   555 -RQKQRSIPKTLSDDPSIYNTAKTG--------DELEDDDDDESI--------------NIPSMS 596
             |:|.|..|..    ||:...:..|        |.|...|:.:|:              ::.|.|
  Rat   550 TRRKVRLEPVL----PSVAALSSAGTMERKFRRDSLFCPDELDSLFSYFDAGAAGAGPRSLSSDS 610

  Fly   597 -LSISRD---DLLVIGDDLALDRL-ETPGILGSDQES-TDGESDAESPEELPFSQLDANQLLYMA 655
             |..|.|   |:|..|....:|.: |..|....:..| .|||::|.|..::  .:|....|.:.|
  Rat   611 GLGGSSDGSSDVLAFGTGSVVDSVTEEEGAESEESSSEVDGEAEAWSLADV--RELHPGLLAHQA 673

  Fly   656 SVVHNLPVMCMAFALGADKMWKNPQDRQRSFLHQAVISGSVMACEFLLLNGAAIDAVDEMGYSAL 720
            :...:||.:..|.|.||:..|.:..|..::.|.|||:.||::.|||||.|||.::..|.:|.:.|
  Rat   674 ARTRDLPALAAALAHGAEVNWADTADEGKTPLVQAVLGGSLIVCEFLLQNGADVNQRDSLGRAPL 738

  Fly   721 HISTAKGHIAQVYLLLKHKAAYDLSSSDGKKALDIAVDQENADIVTLLRLTQLNDEI-------- 777
            |.:|..|...||.|.||..|.......:.:..|.|||...||||||||||.::.:|:
  Rat   739 HHATLLGRTGQVCLFLKRGADQHALDQEQQDPLTIAVQAANADIVTLLRLARMAEEMREAEAPPG 803

  Fly   778 --GPNDEYNGEDETYKNVMKDF 797
              ||....:..:..|:..:::|
  Rat   804 QPGPLPGSSPTELQYRRCIQEF 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	72/198 (36%)
		PH	259..352	CDD:278594	49/93 (53%)
		PH_ACAP	260..355	CDD:270070	51/95 (54%)
		ArfGap	384..497	CDD:279720	67/116 (58%)
		ANK	652..768	CDD:238125	45/115 (39%)
		Ank_4	683..736	CDD:290365	23/52 (44%)
		ANK repeat	687..713	CDD:293786	14/25 (56%)
		ANK repeat	715..746	CDD:293786	11/30 (37%)
Acap3	NP_001382677.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	191	1.000	Domainoid score	I3145
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	541	1.000	Inparanoid score	I1129
OMA	1	1.010	-	-		QHG55583
OrthoDB	1	1.010	-	-		D124295at33208
OrthoFinder	1	1.000	-	-		FOG0000653
OrthoInspector	1	1.000	-	-		otm45066
orthoMCL	1	0.900	-	-		OOG6_101039
Panther	1	1.100	-	-	LDO	PTHR23180
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X412
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880