Protein Alignment CenB1A and Arap2

DIOPT Version :10

• Sequence 1: NP_524458.1
• Gene: CenB1A / 42735
• FlyBaseID: FBgn0039056
• Length: 828
• Species: Drosophila melanogaster
• Sequence 2: XP_038947855.1
• Gene: Arap2 / 305367
• RGDID: 1306452
• Length: 1709
• Species: Rattus norvegicus
• Alignment Length: 714
• Identity: 155/714 - (21%)
• Similarity: 262/714 - (36%)
• Gaps: 232/714 - (32%)

  Fly   114 KDDINQVKDYKGHFLKVSEGYDNALIKNAQASKNRPQEM-------QEAANILSASKSCFQHTAL 171
            |:::.|....:..:..|.|.:.:...||::|||:|.|:.       :.:..:.|.|::....|..
  Rat   399 KNNLPQDSASESEYSTVEECFQSLRRKNSKASKSRTQKAFYLDPFNRHSYPLSSTSENTDPSTIA 463

  Fly   172 DYVNYITLAQARKVPSILSTLLD----------------YYQACVTYYHQGFDLCNDFDEFFKNI 220
            :.::............:.|..||                :....::||:      ||.:.:.|.|
  Rat   464 NAISPYACFYGSSAAKVKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYN------NDREMYSKGI 522

  Fly   221 SEDLNAL-----RGDYQ------------QLEKAMQ-NRHMSVNRYCDSNTNSTSNKIE------ 261
            . .|.|:     :||.:            ::||..: |..:||......:.:.|| :::
  Rat   523 I-PLTAISTVRAQGDNKFEIVTTQRTFVFRVEKEEERNDWISVLLSALKSPSLTS-QLQAAVAPE 585

  Fly   262 --GYLFKKKSKGFKTWCRRWFYLSDNQLVYRKRSNEDSFSVMEEDLRICSVRPVNEGDR--RFCF 322
              |||   :.:|:|.   :.|.:.....|:..::.:|..|.:...:...:|..|.:.||  :..|
  Rat   586 KCGYL---ELRGYKA---KIFTVLRGNSVWLCKTEQDFKSGLGITIIPMNVANVKQIDRAVKQSF 644

  Fly   323 EVISPTKSHILQADSADMLSLWISALQHSIGAAIQHDSTHHSRPQSTNAPNNSLPAKRRIHWEEF 387
            |:|:|.:|....|||......||.|:|.||...:                 :......:|.:.|
  Rat   645 EIITPYRSFSFTADSEKEKQEWIEAVQQSIAETL-----------------SDYEVAEKIWFNE- 691

  Fly   388 LKIPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLDA--WESENVKVMM 450
                .|..|.||::|:|.||||||.:.:|.:|:|.|||||...||||||.:||  |.:|.:::.:
  Rat   692 ----SNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFI 752

  Fly   451 ELGNEVVNRIYEARIGDDCGLKKPTE---QCEIGVREAWIKAKYVERRFVCGMPKPQELLASETA 512
            .:||:..|..:..      .|||..|   ...:..|:.:|..||.|.:|      .:..|||.|.
  Rat   753 VIGNKRANDFWAG------NLKKDEEIQMDSPVDKRKIFITQKYKEGKF------RKTFLASLTK 805

  Fly   513 EVLSIDSGGVVEDGESGGSGIAKRATLSLGGTRKWAVKKLRRRQKQRSIPKTLSDDPSIYNTAKT 577
            |.|:                   :|..:       ||.|                 |.:..|
  Rat   806 EELN-------------------KALCA-------AVVK-----------------PDVLET--- 824

  Fly   578 GDELEDDDDDESINIPSMSLSISRDDLL-VIGDDLALDRLETPGILG-----------------S 624
                             |:|..|..|:: ..||.:..    ||.:|.                 |
  Rat   825 -----------------MALLFSGADVMCATGDPVHC----TPYLLAKKAGQSLQMEFLYHNKFS 868

  Fly   625 DQESTDGESDAESPEELPFSQLDANQLLYMASVVHNLPVMCMAFALGADKMWKNPQDRQRSFLHQ 689
            |....|..|:..|.:|       |.|..::.                             .||:|
  Rat   869 DFPQYDAHSEGGSSQE-------ATQSTFLC-----------------------------DFLYQ 897

  Fly   690 AVISGSVMACEFLLLNGAAID-AVDEMGYSALH----ISTAKG--HIAQVYLLLKHKAAYDLSS 746
            |..|.|.::.|..||...... .|.|.|:.:.:    .:|..|  :|::|..|..||..:.|::
  Rat   898 ATASASRVSTEKKLLEETNKKWCVLEGGFLSYYENDRCTTPNGTINISEVICLTVHKEDFYLNT 961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	21/125 (17%)
		PH_ACAP	260..355	CDD:270070	27/104 (26%)
		ArfGap_ACAP	381..497	CDD:350064	44/120 (37%)
		ANKYR	<647..>768	CDD:440430	22/107 (21%)
		ANK repeat	687..713	CDD:293786	8/26 (31%)
		ANK repeat	715..746	CDD:293786	9/36 (25%)
Arap2	XP_038947855.1	SAM_Arap1,2,3	6..68	CDD:188889
		PH1_ARAP	480..571	CDD:270073	18/97 (19%)
		PH2_ARAP	581..671	CDD:270074	24/95 (25%)
		ArfGap_ARAP2	676..796	CDD:350081	45/153 (29%)
		PH-like	888..998	CDD:473070	20/103 (19%)
		PH-like	1011..1106	CDD:473070
		RhoGAP_ARAP	1110..1289	CDD:239850
		RA_ARAP2	1335..1432	CDD:340747
		PH-like	1438..1549	CDD:473070