DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenB1A and Appl1

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_038951064.1	Gene:	Appl1 / 290537	RGDID:	1309388	Length:	720	Species:	Rattus norvegicus

Alignment Length:	491	Identity:	111/491 - (22%)
Similarity:	206/491 - (41%)	Gaps:	84/491 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IEFEECLKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSL------ 63
            :..||.|:|||:.|..:...|.|...:...:.::.:..:...|:     :|:.:.|..|
  Rat     7 LPIEETLEDSPQTRSLLGVFEEDATAISNYMNQLYQAMHRIYDA-----QNELSAATHLTSKLLK 66

  Fly    64 -WDLQQHFL--DNKNAHNALGKLIHCFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVKDYKG 125
             ::.|:..|  |::...:.|.:......|::..|.:|..|.:..::..:|.|.:.|:.::...|.
  Rat    67 EYEKQRFPLGGDDEVMSSTLQQFSKVIDELSSCHAVLSTQLADAMMFPISQFKERDLKEILTLKE 131

  Fly   126 HFLKVSEGYDNALIKNAQASKNRPQE--MQEAANILSASKSCFQHTALDYVNYITLAQARKVPSI 188
            .|...|..:|.|:.:.::.||.|..:  ..|....:..|:.....|.:.|...:...|.:|..::
  Rat   132 VFQIASNDHDAAINRYSRLSKKRENDKVKYEVTEDVYTSRKKQHQTMMHYFCALNTLQYKKKIAL 196

  Fly   189 LSTLLDYYQACVTYYHQGFDLCN-DFDEFFKNISEDLNALR----GDYQQLEKAMQNRHMS---- 244
            |..||.|.||.::::..|.:..| ..:||..||...:..:|    ||.:.:::.:::..::
  Rat   197 LEPLLGYMQAQISFFKMGSENLNGQLEEFLANIGTSVQNVRREMDGDVETMQQTIEDLEVASDPL 261

  Fly   245 -----------VNRYCDSNTNSTSNKIEGYLFKKKSKGF--KTWCRRWFYLSDNQLVYRKRSNED 296
                       |||      |.|  :..|||..:...|.  .||.|::::.....|:.:.|.  |
  Rat   262 YLPDPDPTKFPVNR------NLT--RKAGYLNARNKTGLVSSTWDRQFYFTQGGNLMSQARG--D 316

  Fly   297 SFSVMEEDLRICSVRPVNEGDRRFCFEVIS--PTKSHILQADSADMLSLWISALQHSIGAAIQHD 359
            ....:..|:..|||..|:..|||:||::.|  ..||.||||:|......||..:.:     |...
  Rat   317 VAGGLAMDIDNCSVMAVDCEDRRYCFQITSFDGKKSSILQAESKKDHEEWICTINN-----ISKQ 376

  Fly   360 STHHSRPQSTNAPNNS--------LPAKRRIHWEEFLKIPGNAYCCDCRSPEPRWASINLGITLC 416
            ......|:.|.|..|.        .|:.::.|  |.|: ||.    ..|.|..|.:|
  Rat   377 IYLSENPEETAARVNQSALEAVTPSPSFQQRH--ESLR-PGG----QSRPPTARTSS-------- 426

  Fly   417 IECSGVHRSLGVHYSKVRSLTLDAWESENVKVMMEL 452
               ||   |||...:.:.:|:||:..:.:..:..::
  Rat   427 ---SG---SLGSESTNLAALSLDSLVAPDTPIQFDI 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	41/210 (20%)
		PH	259..352	CDD:278594	30/96 (31%)
		PH_ACAP	260..355	CDD:270070	30/98 (31%)
		ArfGap	384..497	CDD:279720	16/69 (23%)
		ANK	652..768	CDD:238125
		Ank_4	683..736	CDD:290365
		ANK repeat	687..713	CDD:293786
		ANK repeat	715..746	CDD:293786
Appl1	XP_038951064.1	BAR_APPL1	20..234	CDD:153315	44/218 (20%)
		BAR-PH_APPL	252..376	CDD:270067	36/138 (26%)
		PTB_APPL	506..637	CDD:269980
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910