Protein Alignment CenB1A and Acap1

DIOPT Version :10

• Sequence 1: NP_524458.1
• Gene: CenB1A / 42735
• FlyBaseID: FBgn0039056
• Length: 828
• Species: Drosophila melanogaster
• Sequence 2: NP_001099266.2
• Gene: Acap1 / 287443
• RGDID: 1305360
• Length: 740
• Species: Rattus norvegicus
• Alignment Length: 861
• Identity: 284/861 - (32%)
• Similarity: 422/861 - (49%)
• Gaps: 165/861 - (19%)

  Fly     1 MRATIEFEECLKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWD 65
            |...::||||||||||||..:...|:::..||.||||::||.:..::||..|:....||.:.:.|
  Rat     1 MTVKLDFEECLKDSPRFRASIELVEAEVSELETRLEKLLKLGSCLLESGHHYLAASRAFVVGICD 65

  Fly    66 LQQHFLDNKNAHNALG----KLIHCFQEMNK-------FHTILLDQASRTVLKNLSVFVKDDINQ 119
            |         ||  ||    .:..|.::..:       .|..|||....|:.:.:...||:.:..
  Rat    66 L---------AH--LGPPEPMMAECLEKFTESLNHKLDSHAELLDATQHTLQQQIQTLVKEGLRG 119

  Fly   120 VKDYKGHFLKVSEGYDNALIKNAQASKNRPQEMQEAANILSASKSCFQHTALDYVNYITLAQARK 184
            .::.:..|.:.:|..:.||..||:..:.|.||.::|...|..:::.::..||||...:.:.:.::
  Rat   120 FREARRDFWRGAESLEAALSHNAEVPRRRVQEAEDAGTALRTARAVYRSRALDYALQVNVIEDKR 184

  Fly   185 VPSILSTLLDYYQACVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQQLEKAMQNRHMSVNR-- 247
            ...|:..:|...:|..||:.||.:..|...::.|.:...|:.|..:..:..:.|:.||:.:.:
  Rat   185 KFDIMEFILRLVEAQATYFQQGHEELNQLAQYRKELGAQLHNLVLNSARERRDMEQRHVLLKQKE 249

  Fly   248 ------YCDSNTNSTSNKIEGYLFKKKSKGFKTWCRRWFYLSDNQLVYRKRSNEDSFSVMEEDLR 306
                  .......|:...:||:|||:.|..||||.||||.:.:|||||:|: .:|..:|:.:|||
  Rat   250 LGGEEPEPSLKEGSSGLVMEGHLFKRASNAFKTWSRRWFTIQNNQLVYQKK-YKDPVTVVVDDLR 313

  Fly   307 ICSVRPVNEGDRRFCFEVISPTKSHILQADSADMLSLWISALQHSIGAAIQHD------------ 359
            :|:|:...:.:|||||||:|.:||.:|||||..:|.||:||:|.||.:|....
  Rat   314 LCTVKLCPDSERRFCFEVVSTSKSCLLQADSERLLQLWVSAVQSSIASAFSQAHLENSPRGPGQV 378

  Fly   360 STHHSRPQSTNAPNNSLPAKRRIHWE---------EFLKIPGNAYCCDCRSPEPRWASINLGITL 415
            |.:|| |.|....:...||:.|   |         :...:.|||.||||:.|.|.||||||||||
  Rat   379 SGYHS-PGSAATLSCGGPARGR---EPGGVGQVAAQVQSVDGNAQCCDCKEPAPEWASINLGITL 439

  Fly   416 CIECSGVHRSLGVHYSKVRSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEI 480
            ||:|||:|||||||:|||||||||:||.|.||:|.||||.|:|:|||||: :...:|||...|..
  Rat   440 CIQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCELGNVVINQIYEARV-EAMAVKKPGPSCSR 503

  Fly   481 GVREAWIKAKYVERRFVCGMPKPQELLASETAEVLSIDSGGVVEDGESGGSGIAKRATLSLGGTR 545
            ..:||||.|||||::|:..:|:.:                     |..||.|
  Rat   504 QEKEAWIHAKYVEKKFLTKLPEIR---------------------GRRGGRG------------- 534

  Fly   546 KWAVKKLRRRQKQRSIPKTLSDDPSIYNTAKTGDELEDDDDDESINIPSMSLSISRDDLLVIGDD 610
                       ..|..| .:...|||...:
  Rat   535 -----------PPRGHP-PVPPKPSIRPQS----------------------------------- 552

  Fly   611 LALDRLETPGILGSDQESTDGESDAESPEELPFSQLDANQLLYMAS-VVHNLPVMCMAFALGADK 674
                     ||:         .|.:|||.| ....|....||:.|: ...:||.|..|.|.|||.
  Rat   553 ---------GIV---------RSKSESPSE-DIGSLHPGALLFQAAGYPPSLPTMADALAHGADV 598

  Fly   675 MWKNPQDRQRSFLHQAVISGSVMACEFLLLNGAAIDAVDEMGYSALHISTAKGHIAQVYLLLKHK 739
            .|.|......:.|.:|..:.|::||||||.|||.::..|..|...||.:|..||.....|.||..
  Rat   599 NWVNAGQGNATPLIRATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILGHTGLACLFLKRG 663

  Fly   740 AAYDLSSSDGKKALDIAVDQENADIVTLLRLTQLNDEIGPNDEYNGE--DETYKNVMKDFSKLPA 802
            |......::|:..|.||::..||||||||||.::.:.    :...|:  ||||.::.:|||.:.:
  Rat   664 ADLGARDTEGRDPLTIAMETTNADIVTLLRLAKMREA----EAAQGQTGDETYLDIFRDFSLMAS 724

  Fly   803 SQTRVL-RQRHDSNTL 817
            .....| |:.||.:||
  Rat   725 DDPEKLSRRSHDLHTL 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	52/209 (25%)
		PH_ACAP	260..355	CDD:270070	50/94 (53%)
		ArfGap_ACAP	381..497	CDD:350064	72/124 (58%)
		ANKYR	<647..>768	CDD:440430	46/121 (38%)
		ANK repeat	687..713	CDD:293786	12/25 (48%)
		ANK repeat	715..746	CDD:293786	10/30 (33%)
Acap1	NP_001099266.2	BAR_ACAP1	18..217	CDD:153323	52/209 (25%)
		PH_ACAP	268..364	CDD:270070	51/96 (53%)
		ArfGap_ACAP1	405..524	CDD:350077	71/119 (60%)
		ANK repeat	575..602	CDD:293786	11/26 (42%)
		ANKYR	<592..704	CDD:440430	43/115 (37%)
		ANK repeat	606..637	CDD:293786	12/30 (40%)
		ANK repeat	639..670	CDD:293786	10/30 (33%)