DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenB1A and Acap1

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001099266.2	Gene:	Acap1 / 287443	RGDID:	1305360	Length:	740	Species:	Rattus norvegicus

Alignment Length:	861	Identity:	284/861 - (32%)
Similarity:	422/861 - (49%)	Gaps:	165/861 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRATIEFEECLKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWD 65
            |...::||||||||||||..:...|:::..||.||||::||.:..::||..|:....||.:.:.|
  Rat     1 MTVKLDFEECLKDSPRFRASIELVEAEVSELETRLEKLLKLGSCLLESGHHYLAASRAFVVGICD 65

  Fly    66 LQQHFLDNKNAHNALG----KLIHCFQEMNK-------FHTILLDQASRTVLKNLSVFVKDDINQ 119
            |         ||  ||    .:..|.::..:       .|..|||....|:.:.:...||:.:..
  Rat    66 L---------AH--LGPPEPMMAECLEKFTESLNHKLDSHAELLDATQHTLQQQIQTLVKEGLRG 119

  Fly   120 VKDYKGHFLKVSEGYDNALIKNAQASKNRPQEMQEAANILSASKSCFQHTALDYVNYITLAQARK 184
            .::.:..|.:.:|..:.||..||:..:.|.||.::|...|..:::.::..||||...:.:.:.::
  Rat   120 FREARRDFWRGAESLEAALSHNAEVPRRRVQEAEDAGTALRTARAVYRSRALDYALQVNVIEDKR 184

  Fly   185 VPSILSTLLDYYQACVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQQLEKAMQNRHMSVNR-- 247
            ...|:..:|...:|..||:.||.:..|...::.|.:...|:.|..:..:..:.|:.||:.:.:
  Rat   185 KFDIMEFILRLVEAQATYFQQGHEELNQLAQYRKELGAQLHNLVLNSARERRDMEQRHVLLKQKE 249

  Fly   248 ------YCDSNTNSTSNKIEGYLFKKKSKGFKTWCRRWFYLSDNQLVYRKRSNEDSFSVMEEDLR 306
                  .......|:...:||:|||:.|..||||.||||.:.:|||||:|: .:|..:|:.:|||
  Rat   250 LGGEEPEPSLKEGSSGLVMEGHLFKRASNAFKTWSRRWFTIQNNQLVYQKK-YKDPVTVVVDDLR 313

  Fly   307 ICSVRPVNEGDRRFCFEVISPTKSHILQADSADMLSLWISALQHSIGAAIQHD------------ 359
            :|:|:...:.:|||||||:|.:||.:|||||..:|.||:||:|.||.:|....
  Rat   314 LCTVKLCPDSERRFCFEVVSTSKSCLLQADSERLLQLWVSAVQSSIASAFSQAHLENSPRGPGQV 378

  Fly   360 STHHSRPQSTNAPNNSLPAKRRIHWE---------EFLKIPGNAYCCDCRSPEPRWASINLGITL 415
            |.:|| |.|....:...||:.|   |         :...:.|||.||||:.|.|.||||||||||
  Rat   379 SGYHS-PGSAATLSCGGPARGR---EPGGVGQVAAQVQSVDGNAQCCDCKEPAPEWASINLGITL 439

  Fly   416 CIECSGVHRSLGVHYSKVRSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEI 480
            ||:|||:|||||||:|||||||||:||.|.||:|.||||.|:|:|||||: :...:|||...|..
  Rat   440 CIQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCELGNVVINQIYEARV-EAMAVKKPGPSCSR 503

  Fly   481 GVREAWIKAKYVERRFVCGMPKPQELLASETAEVLSIDSGGVVEDGESGGSGIAKRATLSLGGTR 545
            ..:||||.|||||::|:..:|:.:                     |..||.|
  Rat   504 QEKEAWIHAKYVEKKFLTKLPEIR---------------------GRRGGRG------------- 534

  Fly   546 KWAVKKLRRRQKQRSIPKTLSDDPSIYNTAKTGDELEDDDDDESINIPSMSLSISRDDLLVIGDD 610
                       ..|..| .:...|||...:
  Rat   535 -----------PPRGHP-PVPPKPSIRPQS----------------------------------- 552

  Fly   611 LALDRLETPGILGSDQESTDGESDAESPEELPFSQLDANQLLYMAS-VVHNLPVMCMAFALGADK 674
                     ||:         .|.:|||.| ....|....||:.|: ...:||.|..|.|.|||.
  Rat   553 ---------GIV---------RSKSESPSE-DIGSLHPGALLFQAAGYPPSLPTMADALAHGADV 598

  Fly   675 MWKNPQDRQRSFLHQAVISGSVMACEFLLLNGAAIDAVDEMGYSALHISTAKGHIAQVYLLLKHK 739
            .|.|......:.|.:|..:.|::||||||.|||.::..|..|...||.:|..||.....|.||..
  Rat   599 NWVNAGQGNATPLIRATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILGHTGLACLFLKRG 663

  Fly   740 AAYDLSSSDGKKALDIAVDQENADIVTLLRLTQLNDEIGPNDEYNGE--DETYKNVMKDFSKLPA 802
            |......::|:..|.||::..||||||||||.::.:.    :...|:  ||||.::.:|||.:.:
  Rat   664 ADLGARDTEGRDPLTIAMETTNADIVTLLRLAKMREA----EAAQGQTGDETYLDIFRDFSLMAS 724

  Fly   803 SQTRVL-RQRHDSNTL 817
            .....| |:.||.:||
  Rat   725 DDPEKLSRRSHDLHTL 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	52/209 (25%)
		PH	259..352	CDD:278594	48/92 (52%)
		PH_ACAP	260..355	CDD:270070	50/94 (53%)
		ArfGap	384..497	CDD:279720	71/121 (59%)
		ANK	652..768	CDD:238125	45/116 (39%)
		Ank_4	683..736	CDD:290365	20/52 (38%)
		ANK repeat	687..713	CDD:293786	12/25 (48%)
		ANK repeat	715..746	CDD:293786	10/30 (33%)
Acap1	NP_001099266.2	BAR_ACAP1	18..217	CDD:153323	52/209 (25%)
		PH	266..360	CDD:278594	49/94 (52%)
		PH_ACAP	268..364	CDD:270070	51/96 (53%)
		ArfGap	406..519	CDD:279720	70/113 (62%)
		ANK repeat	575..602	CDD:293786	11/26 (42%)
		ANK	<592..692	CDD:238125	39/99 (39%)
		Ank_5	592..647	CDD:290568	22/54 (41%)
		ANK repeat	606..637	CDD:293786	12/30 (40%)
		Ank_5	626..680	CDD:290568	18/53 (34%)
		ANK repeat	639..670	CDD:293786	10/30 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	157	1.000	Domainoid score	I4061
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	541	1.000	Inparanoid score	I1129
OMA	1	1.010	-	-		QHG55583
OrthoDB	1	1.010	-	-		D124295at33208
OrthoFinder	1	1.000	-	-		FOG0000653
OrthoInspector	1	1.000	-	-		otm45066
orthoMCL	1	0.900	-	-		OOG6_101039
Panther	1	1.100	-	-	O	PTHR23180
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X412
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840